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galP galactose:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947434, updated on 11-Apr-2024

Summary

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Gene symbol
galP
Gene description
galactose:H(+) symporter
Primary source
ASAP:ABE-0009654
Locus tag
b2943
See related
ECOCYC:EG12148
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2938; Pgal
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12148]. GalP is a member of the Major Facilitator Superfamily (MFS) of transporters and is one of two, along with MglABC, major routes for galactose transport into Escherichia coli . [More information is available at EcoCyc: EG12148].
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Genomic context

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Sequence:
NC_000913.3 (3088284..3089678)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YqgC Neighboring gene DUF2684 domain-containing protein YqgD Neighboring gene methionine adenosyltransferase Neighboring gene protein YggI Neighboring gene DNA-specific endonuclease I

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance. Mowla R, et al. Biochim Biophys Acta Biomembr, 2018 Apr. PMID 28890187
  2. Unfolding free energy of a two-domain transmembrane sugar transport protein. Findlay HE, et al. Proc Natl Acad Sci U S A, 2010 Oct 26. PMID 20937906, Free PMC Article
  3. The prototypical H+/galactose symporter GalP assembles into functional trimers. Zheng H, et al. J Mol Biol, 2010 Feb 26. PMID 20006622, Free PMC Article
  4. Solid-state NMR spectroscopy detects interactions between tryptophan residues of the E. coli sugar transporter GalP and the alpha-anomer of the D-glucose substrate. Patching SG, et al. J Am Chem Soc, 2008 Jan 30. PMID 18177040
  5. Low 13C-background for NMR-based studies of ligand binding using 13C-depleted glucose as carbon source for microbial growth: 13C-labeled glucose and 13C-forskolin binding to the galactose-H+ symport protein GalP in Escherichia coli. Patching SG, et al. J Am Chem Soc, 2004 Jan 14. PMID 14709072

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. galactose-binding protein
    Title: Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.
  2. Unfolding free energy of a two-domain transmembrane sugar transport protein, GalP.
    Title: Unfolding free energy of a two-domain transmembrane sugar transport protein.
  3. Each monomer in the trimer forms its own channel, but an additional cavity (10 approximately 15 A in diameter) is apparent at the 3-fold axis of the oligomer.
    Title: The prototypical H+/galactose symporter GalP assembles into functional trimers.
  4. galP is repressed by a combination of NagC, GalR and GalS.
    Title: Repression of galP, the galactose transporter in Escherichia coli, requires the specific regulator of N-acetylglucosamine metabolism.
  5. effects of the galP mutations W56F, W239F, R316W, T336Y and W434F on glucose binding
    Title: Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables galactose:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within galactose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactose:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3088284..3089678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417418.1 galactose:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417418.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ASI2, A0A6M9X6J5, A0A8S7TSV1, F4V5S2
    Conserved Domains (1) summary
    TIGR00879
    Location:9 → 447
    SP; MFS transporter, sugar porter (SP) family
Nucleotide Protein
Heading Accession and Version

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