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nudF ADP-sugar pyrophosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947519, updated on 4-Apr-2024

Summary

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Gene symbol
nudF
Gene description
ADP-sugar pyrophosphatase
Primary source
ASAP:ABE-0009961
Locus tag
b3034
See related
ECOCYC:EG12633
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
aspP; ECK3025; trgB; yqiE
Summary
Nudix hydrolase. [More information is available at EcoGene: EG12184]. ADP-glucose is a precursor molecule for glycogen biosynthesis. [More information is available at EcoCyc: EG12633].
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Genomic context

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Sequence:
NC_000913.3 (3177281..3177910, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene esterase YqiA Neighboring gene cAMP phosphodiesterase Neighboring gene DUF1249 domain-containing protein YqiB Neighboring gene outer membrane channel TolC Neighboring gene DUF1190 domain-containing protein YgiB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytoplasmic Escherichia coli ADP sugar pyrophosphatase binds to cell membranes in response to extracellular signals as the cell population density increases. Morán-Zorzano MT, et al. FEMS Microbiol Lett, 2008 Nov. PMID 18778276
  2. Escherichia coli AspP activity is enhanced by macromolecular crowding and by both glucose-1,6-bisphosphate and nucleotide-sugars. Morán-Zorzano MT, et al. FEBS Lett, 2007 Mar 6. PMID 17306798
  3. Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase. Gabelli SB, et al. Biochemistry, 2002 Jul 30. PMID 12135348
  4. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Gabelli SB, et al. Nat Struct Biol, 2001 May. PMID 11323725
  5. Nucleotide diphosphate hexose pyrophosphatases. Melo A, et al. Biochem Biophys Res Commun, 1966 Mar 8. PMID 5330035

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AspP binds to cell membranes as the bacterial population density increases.
    Title: Cytoplasmic Escherichia coli ADP sugar pyrophosphatase binds to cell membranes in response to extracellular signals as the cell population density increases.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Interaction of purified NDH-1 from Escherichia coli with ubiquinone analogues.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ADP-ribose diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ADP-sugar diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-sugar diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrophosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleoside phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribose phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADP-sugar pyrophosphatase
NP_417506.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3177281..3177910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417506.1 ADP-sugar pyrophosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417506.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MIH0
    Conserved Domains (1) summary
    PRK10729
    Location:9 → 209
    nudF; ADP-ribose pyrophosphatase NudF; Provisional
Nucleotide Protein
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