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glmM phosphoglucosamine mutase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947692, updated on 11-Apr-2024

Summary

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Gene symbol
glmM
Gene description
phosphoglucosamine mutase
Primary source
ASAP:ABE-0010439
Locus tag
b3176
See related
ECOCYC:EG11553
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3165; mrsA; yhbF
Summary
Autophosphorylated enzyme (at Ser-102) is active form. glmM is an essential gene. [More information is available at EcoGene: EG11553]. Phosphoglucosamine mutase catalyzes the interconversion of the glucosamine-6-phosphate (GlcN-6-P) and glucosamine-1-phosphate (GlcN-1-P) isomers. [More information is available at EcoCyc: EG11553].
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Genomic context

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Sequence:
NC_000913.3 (3322733..3324070, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene Sec translocon subunit SecG Neighboring gene dihydropteroate synthase Neighboring gene ATP-dependent zinc metalloprotease FtsH Neighboring gene 23S rRNA 2'-O-ribose U2552 methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophosphorylation of phosphoglucosamine mutase from Escherichia coli. Jolly L, et al. J Bacteriol, 2000 Mar. PMID 10671448, Free PMC Article
  2. Reaction mechanism of phosphoglucosamine mutase from Escherichia coli. Jolly L, et al. Eur J Biochem, 1999 May. PMID 10231382
  3. Bis(zinc(II)-dipicolylamine)-functionalized sub-2 μm core-shell microspheres for the analysis of N-phosphoproteome. Hu Y, et al. Nat Commun, 2020 Dec 4. PMID 33277485, Free PMC Article
  4. The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome. Dallas WS, et al. J Bacteriol, 1993 Dec. PMID 8244950, Free PMC Article
  5. Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Kumar JK, et al. Proc Natl Acad Sci U S A, 2004 Mar 16. PMID 15004283, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglucosamine mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoglucosamine mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglucosamine mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphomannomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoglucosamine mutase
NP_417643.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3322733..3324070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417643.1 phosphoglucosamine mutase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417643.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6P939
    Conserved Domains (1) summary
    PRK10887
    Location:4 → 445
    glmM; phosphoglucosamine mutase; Provisional
Nucleotide Protein
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