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kdsC 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947717, updated on 4-Feb-2024

Summary

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Gene symbol
kdsC
Gene description
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
Primary source
ASAP:ABE-0010506
Locus tag
b3198
See related
ECOCYC:G7663
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3187; yrbI; yrbJ
Summary
YrbI is renamed as KdsC (personal comm., R.W. [More information is available at EcoGene: EG12804]. 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase is specific for the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate. [More information is available at EcoCyc: G7663].
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Genomic context

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Sequence:
NC_000913.3 (3342273..3342839)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YrbG Neighboring gene D-arabinose 5-phosphate isomerase KdsD Neighboring gene lipopolysaccharide transport system protein LptC Neighboring gene lipopolysaccharide transport system protein LptA Neighboring gene lipopolysaccharide transport system ATP binding protein LptB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase. Biswas T, et al. J Biol Chem, 2009 Oct 30. PMID 19726684, Free PMC Article
  2. From structure to function: YrbI from Haemophilus influenzae (HI1679) is a phosphatase. Parsons JF, et al. Proteins, 2002 Mar 1. PMID 11835514, Free PMC Article
  3. 3-Deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) phosphatase. Ray PH, et al. Methods Enzymol, 1982. PMID 6285136
  4. Purification and characterization of specific 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Escherichia coli B. Ray PH, et al. J Bacteriol, 1980 Apr. PMID 6246070, Free PMC Article
  5. Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase. Wu J, et al. J Biol Chem, 2003 May 16. PMID 12639950

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. structural and kinetic analysis strongly suggests that the binding of the flexible C-terminal region (tail) to the active site makes KdsC catalytically efficient by facilitating product release
    Title: The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-deoxy-manno-octulosonate-8-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
NP_417665.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3342273..3342839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417665.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417665.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827QNP5
    Conserved Domains (1) summary
    PRK09484
    Location:6 → 188
    PRK09484; 3-deoxy-manno-octulosonate-8-phosphatase KdsC
Nucleotide Protein
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