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nanE putative N-acetylmannosamine-6-phosphate 2-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947745, updated on 23-Nov-2023

Summary

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Gene symbol
nanE
Gene description
putative N-acetylmannosamine-6-phosphate 2-epimerase
Primary source
ASAP:ABE-0010575
Locus tag
b3223
See related
ECOCYC:G7677
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3212; yhcJ
Summary
NanE is not predicted to be a lipoprotein by LipOP or PATOSEQ, but is listed in DOLOP as a putative lipoprotein. [More information is available at EcoGene: EG12816]. NanE is predicted to encode N-acetylmannosamine-6-phosphate epimerase, an enzyme involved in the utilization of N-acetylneuraminate and N-acetylmannosamine as carbon sources . [More information is available at EcoCyc: G7677].
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Genomic context

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Sequence:
NC_000913.3 (3370347..3371036, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1016 domain-containing protein YhcG Neighboring gene N-acetylneuraminate anomerase Neighboring gene N-acetylmannosamine kinase Neighboring gene N-acetylneuraminate:H(+) symporter Neighboring gene N-acetylneuraminate lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of GlcNAc-6-P 2-epimerase from Escherichia coli K92. Ferrero MA, et al. Acta Biochim Pol, 2007. PMID 17565386
  2. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. Rodionova IA, et al. J Bacteriol, 2018 Mar 1. PMID 29229699, Free PMC Article
  3. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article
  4. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. Kalivoda KA, et al. J Bacteriol, 2003 Aug. PMID 12897000, Free PMC Article
  5. Diversity of microbial sialic acid metabolism. Vimr ER, et al. Microbiol Mol Biol Rev, 2004 Mar. PMID 15007099, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We provide evidence here that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein allosterically activate NagB by direct protein-protein interactions.
    Title: The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acylglucosamine-6-phosphate 2-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylglucosamine-6-phosphate 2-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acylglucosamine-6-phosphate 2-epimerase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables N-acylmannosamine-6-phosphate 2-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylmannosamine-6-phosphate 2-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylmannosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acetylmannosamine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in N-acetylmannosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative N-acetylmannosamine-6-phosphate 2-epimerase
NP_417690.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3370347..3371036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417690.1 putative N-acetylmannosamine-6-phosphate 2-epimerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417690.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6V2N6, A0A831M649
    Conserved Domains (1) summary
    COG3010
    Location:1 → 227
    NanE; Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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