asd aspartate-semialdehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: asd
Gene description: aspartate-semialdehyde dehydrogenase
Primary source: ASAP:ABE-0011211
Locus tag: b3433
See related: ECOCYC:EG10088
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: dap; ECK3419; hom
Summary: Aspartate semialdehyde dehydrogenase (Asd) carries out the middle step in the pathway of homoserine biosynthesis, generating L-aspartate-semialdehyde. [More information is available at EcoCyc: EG10088].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data indicate that a novel substrate binding interaction was discovered: hydrogen bonding between the substrate and aspartate semialdehyde dehydrogenase (ASADH).
Title: Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.
N-terminus verified by Edman degradation on complete protein
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables aspartate-semialdehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartate-semialdehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' L-methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in diaminopimelate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homoserine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in isoleucine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lysine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate	IDA Inferred from Direct Assay more info	PubMed
involved_in lysine biosynthetic process via diaminopimelate	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in threonine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_417891.1

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The following sections contain reference sequences that belong to a specific genome build. Explain