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gabP 4-aminobutanoate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948049, updated on 4-Apr-2024

Summary

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Gene symbol
gabP
Gene description
4-aminobutanoate:H(+) symporter
Primary source
ASAP:ABE-0008763
Locus tag
b2663
See related
ECOCYC:EG11330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2657
Summary
GabP is a 4-aminobutyrate (GABA) transporter that is a member of the Amino Acid Polyamine Organocation (APC) Superfamily of transporters . [More information is available at EcoCyc: EG11330].
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Genomic context

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Sequence:
NC_000913.3 (2794253..2795653)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinate-semialdehyde dehydrogenase (NADP(+)) GabD Neighboring gene 4-aminobutyrate aminotransferase GabT Neighboring gene DNA-binding transcriptional repressor GlaR Neighboring gene K(+) binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli. Zhang W, et al. J Biol Chem, 2005 Jul 15. PMID 15890647
  2. Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP. King SC, et al. Biochem J, 2003 Dec 15. PMID 12956624, Free PMC Article
  3. Induction of substrate specificity shifts by placement of alanine insertions within the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP. King SC, et al. Biochem J, 2003 Dec 15. PMID 12956623, Free PMC Article
  4. Membrane topology of the Escherichia coli gamma-aminobutyrate transporter: implications on the topography and mechanism of prokaryotic and eukaryotic transporters from the APC superfamily. Hu LA, et al. Biochem J, 1998 Nov 15. PMID 9806886, Free PMC Article
  5. Substrate specificity of the Escherichia coli 4-aminobutyrate carrier encoded by gabP. Uptake and counterflow of structurally diverse molecules. Brechtel CE, et al. J Biol Chem, 1996 Jan 12. PMID 8557687

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GabP of Escherichia coli is affected both topologically and kinetically by membrane lipids
    Title: Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables gamma-aminobutyric acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables gamma-aminobutyric acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables secondary active transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to nitrogen starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in gamma-aminobutyric acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to carbon starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-aminobutanoate:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2794253..2795653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417149.1 4-aminobutanoate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417149.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A828GVP1
    Conserved Domains (1) summary
    PRK10197
    Location:21 → 466
    PRK10197; GABA permease
Nucleotide Protein
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