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yfaU 2-keto-3-deoxy-L-rhamnonate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948054, updated on 4-Feb-2024

Summary

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Gene symbol
yfaU
Gene description
2-keto-3-deoxy-L-rhamnonate aldolase
Primary source
ASAP:ABE-0007431
Locus tag
b2245
See related
ECOCYC:G7158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2238
Summary
2-keto-3-deoxy-L-rhamnonate aldolase also performs a retroaldol reaction on the other products of RhamD 2-keto-3-deoxy-l-mannonate and 2-keto-3-deoxy-l-lyxonate indicating a coupled pathway of assimilation of the RhamD substrates which are likely to be imported using the neighboring transporter homolog YfaV; all three genes appear to be in a yfaXWVU operon with the YfaX predicted regulator (Rea, 2008). [More information is available at EcoGene: EG14083]. YfaU is a 2-keto-3-deoxy-L-rhamnonate aldolase which catalyzes a retro-aldol reaction with somewhat relaxed substrate specificity . [More information is available at EcoCyc: G7158].
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Genomic context

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Sequence:
NC_000913.3 (2358042..2358845, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inactive recombination-promoting nuclease-like protein RpnE Neighboring gene pseudo Neighboring gene putative transporter YfaV Neighboring gene L-rhamnonate dehydratase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, purification, crystallization and preliminary characterization of an HHED aldolase homologue from Escherichia coli K12. Wright A, et al. Acta Crystallogr D Biol Crystallogr, 2002 Dec. PMID 12454498
  2. Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Rea D, et al. Biochemistry, 2008 Sep 23. PMID 18754683
  3. Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. Rakus JF, et al. Biochemistry, 2008 Sep 23. PMID 18754693, Free PMC Article
  4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
2-keto-3-deoxy-L-rhamnonate aldolase
NP_416748.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2358042..2358845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416748.1 2-keto-3-deoxy-L-rhamnonate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416748.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5YH23
    Conserved Domains (1) summary
    PRK10128
    Location:1 → 267
    PRK10128; 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional
Nucleotide Protein
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