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lhgD L-2-hydroxyglutarate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948069, updated on 2-May-2024

Summary

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Gene symbol
lhgD
Gene description
L-2-hydroxyglutarate dehydrogenase
Primary source
ASAP:ABE-0008756
Locus tag
b2660
See related
ECOCYC:EG12387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2654; lhgO; ygaF
Summary
LhgO is an L-2-hydroxyglutarate oxidase that is probably involved with recovering alpha-ketoglutarate (Kalliri, 2008). [More information is available at EcoGene: EG12387]. LhgO is a L-2-hydroxyglutarate oxidase that contains an FAD cofactor which is not covalently attached. [More information is available at EcoCyc: EG12387].
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Genomic context

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Sequence:
NC_000913.3 (2789982..2791250)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glutarate dioxygenase GlaH Neighboring gene succinate-semialdehyde dehydrogenase (NADP(+)) GabD Neighboring gene 4-aminobutyrate aminotransferase GabT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. Kalliri E, et al. J Bacteriol, 2008 Jun. PMID 18390652, Free PMC Article
  2. Role of activator site position and a distal UP-element half-site for sigma factor selectivity at a CRP/H-NS-activated sigma(s)-dependent promoter in Escherichia coli. Germer J, et al. Mol Microbiol, 2001 Aug. PMID 11532138
  3. Multiple stress signal integration in the regulation of the complex sigma S-dependent csiD-ygaF-gabDTP operon in Escherichia coli. Metzner M, et al. Mol Microbiol, 2004 Feb. PMID 14731280
  4. What makes an Escherichia coli promoter sigma(S) dependent? Role of the -13/-14 nucleotide promoter positions and region 2.5 of sigma(S). Becker G, et al. Mol Microbiol, 2001 Mar. PMID 11251833
  5. DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli. DeLisa MP, et al. J Bacteriol, 2001 Sep. PMID 11514505, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (S)-2-hydroxyglutarate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-hydroxyglutarate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-hydroxyglutarate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-hydroxyglutarate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-lysine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine catabolic process EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
L-2-hydroxyglutarate dehydrogenase
NP_417146.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2789982..2791250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417146.2 L-2-hydroxyglutarate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417146.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L5V7C7
    Conserved Domains (1) summary
    PRK11728
    Location:1 → 393
    PRK11728; L-2-hydroxyglutarate oxidase
Nucleotide Protein
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