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lldP lactate/glycolate:H(+) symporter LldP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948114, updated on 4-Apr-2024

Summary

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Gene symbol
lldP
Gene description
lactate/glycolate:H(+) symporter LldP
Primary source
ASAP:ABE-0011777
Locus tag
b3603
See related
ECOCYC:EG11961
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3593; lct; lctP
Summary
IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG11961]. LctP is a probable lactate/proton symporter responsible for the uptake of L-lactate. [More information is available at EcoCyc: EG11961].
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Genomic context

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Sequence:
NC_000913.3 (3777399..3779054)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YibT Neighboring gene DUF2810 domain-containing protein YibL Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene L-lactate dehydrogenase Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Núñez MF, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785976
  2. Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation. Erwin AL, et al. J Bacteriol, 1996 Aug. PMID 8759842, Free PMC Article
  3. Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli. Aguilera L, et al. J Bacteriol, 2008 Apr. PMID 18263722, Free PMC Article
  4. Mapping the xyl, mtl, and lct loci in Escherichia coli K-12. Lin RJ, et al. J Bacteriol, 1983 Nov. PMID 6313625, Free PMC Article
  5. Vinylglycolate resistance in Escherichia coli. Shaw L, et al. J Bacteriol, 1975 Mar. PMID 1090585, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results are consistent with the hypothesis that LldR has a dual role, acting as a repressor or an activator of lldPRD operon.
    Title: Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lactate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
lactate/glycolate:H(+) symporter LldP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3777399..3779054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418060.1 lactate/glycolate:H(+) symporter LldP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418060.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6ZX80
    Conserved Domains (1) summary
    PRK10420
    Location:1 → 551
    PRK10420; L-lactate permease; Provisional
Nucleotide Protein
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