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lldD L-lactate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948121, updated on 23-Nov-2023

Summary

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Gene symbol
lldD
Gene description
L-lactate dehydrogenase
Primary source
ASAP:ABE-0011784
Locus tag
b3605
See related
ECOCYC:EG11963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3595; lct; lctD
Summary
Arc regulon. [More information is available at EcoGene: EG11963]. L-lactate dehydrogenase is an FMN-dependent membrane-associated dehydrogenase . [More information is available at EcoCyc: EG11963].
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Genomic context

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Sequence:
NC_000913.3 (3779827..3781017)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2810 domain-containing protein YibL Neighboring gene lactate/glycolate:H(+) symporter LldP Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase Neighboring gene serine acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Limiting availability of binding sites for dehydrogenases on the cell membrane of Escherichia coli. Kung HF, et al. Proc Natl Acad Sci U S A, 1972 Apr. PMID 4554536, Free PMC Article
  2. Effects of phospholipids on L-lactate dehydrogenase from membranes of Escherichia coli. Activation and stabilization of the enzyme with phospholipids. Kimura H, et al. J Biol Chem, 1978 Feb 25. PMID 342518
  3. Inducible membrane-bound L-lactate dehydrogenase from Escherichia coli. Purification and properties. Futai M, et al. J Biol Chem, 1977 Aug 25. PMID 18473
  4. Evolution of L-1, 2-propanediol catabolism in Escherichia coli by recruitment of enzymes for L-fucose and L-lactate metabolism. Cocks GT, et al. J Bacteriol, 1974 Apr. PMID 4595205, Free PMC Article
  5. Mechanisms of active transport in isolated bacterial membrane vesicles. X. Inactivation of D-lactate dehydrogenase and D-lactate dehydrogenase-coupled transport in Escherichia coli membrane vesicles by an acetylenic substrate. Walsh CT, et al. J Biol Chem, 1972 Dec 25. PMID 4565667

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results are consistent with the hypothesis that LldR has a dual role, acting as a repressor or an activator of lldPRD operon.
    Title: Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-fucose catabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lactate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactate oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lactate oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
L-lactate dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3779827..3781017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418062.1 L-lactate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418062.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MKZ5, A0A797I3W7, A0A827Y8Z6
    Conserved Domains (1) summary
    PRK11197
    Location:1 → 380
    lldD; L-lactate dehydrogenase; Provisional
Nucleotide Protein
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