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wzxE lipid IIIECA flippase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948294, updated on 23-Nov-2023

Summary

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Gene symbol
wzxE
Gene description
lipid IIIECA flippase
Primary source
ASAP:ABE-0012386
Locus tag
b3792
See related
ECOCYC:EG11486
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3784; wzx; yifJ
Summary
WzxE is a "flippase" responsible for movement of lipid III (Fuc4NAc-ManNAcA-GlcNAc-P-P-undecaprenol) across the membrane bilayer . [More information is available at EcoCyc: EG11486].
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Genomic context

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Sequence:
NC_000913.3 (3976278..3977528)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glucose-1-phosphate thymidylyltransferase 2 Neighboring gene RffC Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase Neighboring gene TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase Neighboring gene enterobacterial common antigen polymerase Neighboring gene UDP-N-acetyl-D-mannosaminuronic acid transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides. Alaimo C, et al. EMBO J, 2006 Mar 8. PMID 16498400, Free PMC Article
  2. The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escherichia coli O antigen assembly is independent of the chemical structure of the O repeat. Feldman MF, et al. J Biol Chem, 1999 Dec 3. PMID 10574995
  3. Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence. Ramos-Morales F, et al. J Bacteriol, 2003 Sep. PMID 12923112, Free PMC Article
  4. The modality of enterobacterial common antigen polysaccharide chain lengths is regulated by o349 of the wec gene cluster of Escherichia coli K-12. Barr K, et al. J Bacteriol, 1999 Oct. PMID 10515954, Free PMC Article
  5. Outer membrane vesicle production by Escherichia coli is independent of membrane instability. McBroom AJ, et al. J Bacteriol, 2006 Aug. PMID 16855227, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables intramembrane lipid transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in enterobacterial common antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid translocation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipid IIIECA flippase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3976278..3977528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418239.1 lipid IIIECA flippase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418239.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1J7V7
    Conserved Domains (1) summary
    PRK15099
    Location:1 → 416
    PRK15099; lipid III flippase WzxE
Nucleotide Protein
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