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ubiD 3-octaprenyl-4-hydroxybenzoate decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948326, updated on 2-May-2024

Summary

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Gene symbol
ubiD
Gene description
3-octaprenyl-4-hydroxybenzoate decarboxylase
Primary source
ASAP:ABE-0012557
Locus tag
b3843
See related
ECOCYC:EG11396
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3835; yigC; yigY
Summary
AFMB Structural Genomics target Number 3 (http://afmb.cnrs-mrs.fr/article171. [More information is available at EcoGene: EG11396]. 3-Octaprenyl-4-hydroxybenzoate decarboxylase catalyzes the third step in the biosynthesis of ubiquinone. [More information is available at EcoCyc: EG11396].
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Genomic context

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Sequence:
NC_000913.3 (4024988..4026481)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene twin arginine protein translocation system - TatC protein Neighboring gene 3' -> 5' ssDNA/RNA exonuclease TatD Neighboring gene transcription antiterminator RfaH Neighboring gene NAD(P)H-flavin reductase Neighboring gene 3-ketoacyl-CoA thiolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis. Marshall SA, et al. J Biol Chem, 2017 Mar 17. PMID 28057757, Free PMC Article
  2. Biosynthesis of ubiquinone in Escherichia coli K-12: location of genes affecting the metabolism of 3-octaprenyl-4-hydroxybenzoic acid and 2-octaprenylphenol. Cox GB, et al. J Bacteriol, 1969 Aug. PMID 4897112, Free PMC Article
  3. Low ubiquinone content in Escherichia coli causes thiol hypersensitivity. Zeng H, et al. J Bacteriol, 1998 Jul. PMID 9658014, Free PMC Article
  4. Alternative hydroxylases for the aerobic and anaerobic biosynthesis of ubiquinone in Escherichia coli. Alexander K, et al. Biochemistry, 1978 Oct 31. PMID 365223
  5. The role of UbiX in Escherichia coli coenzyme Q biosynthesis. Gulmezian M, et al. Arch Biochem Biophys, 2007 Nov 15. PMID 17889824, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prenyl-FMNH2 binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquinone biosynthetic process from chorismate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-octaprenyl-4-hydroxybenzoate decarboxylase
NP_418285.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4024988..4026481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418285.1 3-octaprenyl-4-hydroxybenzoate decarboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418285.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9Q760, A0A827Y258, A0A8S7JTX9
    Conserved Domains (1) summary
    PRK10922
    Location:1 → 497
    PRK10922; 4-hydroxy-3-polyprenylbenzoate decarboxylase
Nucleotide Protein
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