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yigB 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948357, updated on 2-May-2024

Summary

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Gene symbol
yigB
Gene description
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
Primary source
ASAP:ABE-0012450
Locus tag
b3812
See related
ECOCYC:EG11202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3807
Summary
HAD superfamily. [More information is available at EcoGene: EG11202]. YigB is an FMN phosphatase that belongs to the superfamily of haloacid dehalogenase (HAD)-like hydrolases . yigB is important for formation of dormant persister cells; overexpression of yigB leads to increased tolerance to ofloxacin . [More information is available at EcoCyc: EG11202].
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Genomic context

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Sequence:
NC_000913.3 (3997183..3997899)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene diaminopimelate epimerase Neighboring gene DUF484 domain-containing protein YigA Neighboring gene site-specific tyrosine recombinase Neighboring gene DNA helicase II Neighboring gene DUF2233 domain-containing protein YigE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nucleotide sequence of the uvrD gene of E. coli. Finch PW, et al. Nucleic Acids Res, 1984 Jul 25. PMID 6379604, Free PMC Article
  2. Transcription of the uvrD gene of Escherichia coli is controlled by the lexA repressor and by attenuation. Easton AM, et al. Nucleic Acids Res, 1983 Dec 20. PMID 6324092, Free PMC Article
  3. Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis. Haase I, et al. Chembiochem, 2013 Nov 25. PMID 24123841
  4. Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases. Colloms SD, et al. J Bacteriol, 1990 Dec. PMID 2254268, Free PMC Article
  5. Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Hansen S, et al. Antimicrob Agents Chemother, 2008 Aug. PMID 18519731, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dormancy process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in riboflavin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within riboflavin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in small molecule biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
NP_418257.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3997183..3997899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418257.1 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418257.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AME9, A0A7H9SJS0
    Conserved Domains (1) summary
    PRK10748
    Location:1 → 238
    PRK10748; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB
Nucleotide Protein
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