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ppc phosphoenolpyruvate carboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948457, updated on 2-May-2024

Summary

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Gene symbol
ppc
Gene description
phosphoenolpyruvate carboxylase
Primary source
ECOCYC:EG10756
Locus tag
b3956
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
asp; ECK3947; glu
Summary
Mutant has reduced growth rate with little acetate excreation, decrease glucose consumption and a decreased carbon dioxide evolution rate. [More information is available at EcoGene: EG10756]. Mutants in the ppc gene have been isolated and studied . [More information is available at EcoCyc: EG10756].
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Genomic context

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Sequence:
NC_000913.3 (4150447..4153098, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative PTS enzyme IIB component FrwD Neighboring gene putative DNA-binding transcriptional regulator YijO Neighboring gene phosphoethanolamine transferase EptC Neighboring gene acetylornithine deacetylase Neighboring gene N-acetylglutamylphosphate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Xu YF, et al. Nat Chem Biol, 2012 Apr 22. PMID 22522319, Free PMC Article
  2. Construction and characterization of a PPC (phosphoenolpyruvate carboxylase) knockout mutant of Escherichia coli. Vandedrinck S, et al. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet, 2001. PMID 15954317
  3. Phosphoenolpyruvate carboxylase: a new era of structural biology. Izui K, et al. Annu Rev Plant Biol, 2004. PMID 15725057
  4. Increasing the acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli. Lin H, et al. Biotechnol Prog, 2004 Sep-Oct. PMID 15458351
  5. Effect of ppc gene knockout on the metabolism of Escherichia coli in view of gene expressions, enzyme activities and intracellular metabolite concentrations. Peng L, et al. Appl Microbiol Biotechnol, 2004 Feb 13. PMID 14963616

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoenolpyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoenolpyruvate carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoenolpyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbon fixation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxaloacetate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oxaloacetate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoenolpyruvate carboxylase
NP_418391.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4150447..4153098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418391.1 phosphoenolpyruvate carboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418391.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895NT82
    Conserved Domains (1) summary
    PRK00009
    Location:1 → 883
    PRK00009; phosphoenolpyruvate carboxylase; Reviewed
Nucleotide Protein
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