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aceA isocitrate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948517, updated on 2-May-2024

Summary

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Gene symbol
aceA
Gene description
isocitrate lyase
Primary source
ASAP:ABE-0013128
Locus tag
b4015
See related
ECOCYC:EG10022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4007; icl
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Genomic context

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Sequence:
NC_000913.3 (4217109..4218413)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene homoserine O-succinyltransferase Neighboring gene malate synthase A Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase kinase/phosphatase Neighboring gene regulator of acetyl CoA synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of isocitrate lyase and the glyoxylate cycle in Escherichia coli growing under glucose limitation. Prasad Maharjan R, et al. Res Microbiol, 2005 Mar. PMID 15748982
  2. Amino acid residues involved in cold adaptation of isocitrate lyase from a psychrophilic bacterium, Colwellia maris. Watanabe S, et al. Microbiology (Reading), 2004 Oct. PMID 15470117
  3. The structure and domain organization of Escherichia coli isocitrate lyase. Britton KL, et al. Acta Crystallogr D Biol Crystallogr, 2001 Sep. PMID 11526312
  4. The importance of four histidine residues in isocitrate lyase from Escherichia coli. Diehl P, et al. J Bacteriol, 1994 Feb. PMID 8300547, Free PMC Article
  5. Site-directed mutagenesis of cysteine-195 in isocitrate lyase from Escherichia coli ML308. Robertson AG, et al. Biochem J, 1995 Jan 1. PMID 7826335, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cation binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isocitrate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glyoxylate cycle IC
Inferred by Curator
more info
 PubMed 
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
isocitrate lyase
NP_418439.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4217109..4218413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418439.1 isocitrate lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418439.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9MNK4
    Conserved Domains (1) summary
    PRK15063
    Location:1 → 434
    PRK15063; isocitrate lyase; Provisional
Nucleotide Protein
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