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malK maltose ABC transporter ATP binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948537, updated on 11-Apr-2024

Summary

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Gene symbol
malK
Gene description
maltose ABC transporter ATP binding subunit
Primary source
ASAP:ABE-0013216
Locus tag
b4035
See related
ECOCYC:EG10558
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4027; malB
Summary
The inactive, ATP-bound form of MalK directly antagonizes the mal regulon activator MalT. [More information is available at EcoGene: EG10558]. MalK is the ATP-binding component of the maltose ABC transporter. [More information is available at EcoCyc: EG10558].
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Genomic context

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Sequence:
NC_000913.3 (4246784..4247899)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltose ABC transporter membrane subunit MalF Neighboring gene maltose ABC transporter periplasmic binding protein Neighboring gene maltose outer membrane channel/phage lambda receptor protein Neighboring gene maltose regulon periplasmic protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coupling between ATP hydrolysis and protein conformational change in maltose transporter. Lv X, et al. Proteins, 2017 Feb. PMID 27616441
  2. ATP-induced conformational changes of nucleotide-binding domains in an ABC transporter. Importance of the water-mediated entropic force. Hayashi T, et al. J Phys Chem B, 2014 Nov 6. PMID 25302667
  3. A network of dynamically conserved residues deciphers the motions of maltose transporter. Lukman S, et al. Proteins, 2009 Aug 15. PMID 19274733
  4. Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter. Fetsch EE, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12093921, Free PMC Article
  5. Identification of a cytoplasmic membrane-associated component of the maltose transport system of Escherichia coli. Bavoil P, et al. J Biol Chem, 1980 Sep 25. PMID 6997295

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coupling between ATP hydrolysis and protein conformational change in maltose transporter MalK has been described.
    Title: Coupling between ATP hydrolysis and protein conformational change in maltose transporter.
  2. Data indicate that MalFGK2 transporter is comprised of two membrane proteins, MalF and MalG, and the nucleotide-binding domain, which controls the conformation of MalFG, is composed of the homodimeric MalK subunit.
    Title: Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter.
  3. Data suggest that the binding and conformational change of maltose transporter (MalFGK2) may provide some insights into the understanding of the mechanism of ABC transporters.
    Title: Allosteric transitions of the maltose transporter studied by an elastic network model.
  4. The water-mediated entropic force is important for ATP-induced conformational changes of nucleotide-binding domains in MalK.
    Title: ATP-induced conformational changes of nucleotide-binding domains in an ABC transporter. Importance of the water-mediated entropic force.
  5. Escherichia coli maltose binding protein has inhibitory effects on beta-amyloid aggregation and cytotoxicity
    Title: The inhibitory effects of Escherichia coli maltose binding protein on β-amyloid aggregation and cytotoxicity.
  6. The molecular entity that interacts with MalT is not free MalK, but the maltose transporter, MalFGK(2) , which sequesters MalT to the membrane.
    Title: The ABC transporter MalFGK(2) sequesters the MalT transcription factor at the membrane in the absence of cognate substrate.
  7. using x-ray crystallography, study captured the maltose transporter in an intermediate step between the inward- and outward-facing states
    Title: Crystal structure of the maltose transporter in a pretranslocation intermediate state.
  8. substrate availability is communicated from MalE to the MalK dimer via extracytoplasmic loops of MalFG
    Title: Maltose binding protein (MalE) interacts with periplasmic loops P2 and P1 respectively of the MalFG subunits of the maltose ATP binding cassette transporter (MalFGK(2)) from Escherichia coli/Salmonella during the transport cycle.
  9. 2.8-A crystal structure of the intact maltose transporter in complex with the maltose-binding protein, maltose and ATP
    Title: Crystal structure of a catalytic intermediate of the maltose transporter.
  10. ATP-driven MalK dimer closure and reopening are crucial steps in the translocation cycle of the intact maltose transporter MalFGK2
    Title: ATP-driven MalK dimer closure and reopening and conformational changes of the "EAA" motifs are crucial for function of the maltose ATP-binding cassette transporter (MalFGK2).
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type maltose transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ABC-type maltose transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type maltose transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within maltodextrin transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maltodextrin transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maltose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within maltose transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of maltose transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex IEA
Inferred from Electronic Annotation
more info
  
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of enzyme IIA-maltose transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of maltose transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of maltose transport complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of maltose transport complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maltose ABC transporter ATP binding subunit
NP_418459.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4246784..4247899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418459.1 maltose ABC transporter ATP binding subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418459.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7I4J8, A0A8T6BIJ2
    Conserved Domains (1) summary
    PRK11000
    Location:1 → 371
    PRK11000; maltose/maltodextrin ABC transporter ATP-binding protein MalK
Nucleotide Protein
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