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ubiA 4-hydroxybenzoate octaprenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948540, updated on 2-May-2024

Summary

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Gene symbol
ubiA
Gene description
4-hydroxybenzoate octaprenyltransferase
Primary source
ASAP:ABE-0013229
Locus tag
b4040
See related
ECOCYC:EG11370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cyr; ECK4032
Summary
4-Hydroxybenzoate octaprenyltransferase is the second enzyme in the pathway of ubiquinone biosynthesis. [More information is available at EcoCyc: EG11370].
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Genomic context

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Sequence:
NC_000913.3 (4253016..4253888)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene chorismate lyase Neighboring gene glycerol-3-phosphate 1-O-acyltransferase Neighboring gene diacylglycerol kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A structural model of the membrane-bound aromatic prenyltransferase UbiA from E. coli. Bräuer L, et al. Chembiochem, 2008 Apr 14. PMID 18338424
  2. Biochemical study on ubiquinone biosynthesis in Escherichia coli : I. Specificity of para hydroxybenzoate polyprenyltransferase. el-Hachimi Z, et al. Biochimie, 1974. PMID 4615746
  3. Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12:4-hydroxybenzoate octaprenyltransferase. Young IG, et al. J Bacteriol, 1972 Apr. PMID 4552989, Free PMC Article
  4. Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes. Heide L, et al. J Bacteriol, 1993 Sep. PMID 8366060, Free PMC Article
  5. Isolation of recombinant plasmids and phage carrying the lexA gene of Escherichia coli K-12. Little JW. Gene, 1980 Aug. PMID 6254842

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular model and study of catalytic mechanism of ubiA transferase.
    Title: Modeling the E. coli 4-hydroxybenzoic acid oligoprenyltransferase ( ubiA transferase) and characterization of potential active sites.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-hydroxybenzoate decaprenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-hydroxybenzoate nonaprenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-hydroxybenzoate octaprenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxybenzoate octaprenyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxybenzoate octaprenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-hydroxybenzoate octaprenyltransferase
NP_418464.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4253016..4253888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418464.1 4-hydroxybenzoate octaprenyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418464.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BKA5, A0AA87EWX6
    Conserved Domains (1) summary
    PRK12848
    Location:6 → 287
    ubiA; 4-hydroxybenzoate octaprenyltransferase
Nucleotide Protein
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