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mtn 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948542, updated on 4-Apr-2024

Summary

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Gene symbol
mtn
Gene description
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Primary source
ASAP:ABE-0000545
Locus tag
b0159
See related
ECOCYC:EG11090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0158; mtnN; pfs; yadA
Summary
Mutants accumulate 5'-deoxyadenosine and have impaired biotin synthase activity. [More information is available at EcoGene: EG11090]. The mtn gene encodes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase . [More information is available at EcoCyc: EG11090].
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Genomic context

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Sequence:
NC_000913.3 (178455..179153, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YadW Neighboring gene iron-sulfur cluster insertion protein ErpA Neighboring gene PF03458 family protein YadS Neighboring gene vitamin B12 ABC transporter periplasmic binding protein Neighboring gene dGTP triphosphohydrolase Neighboring gene periplasmic serine endoprotease DegP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Thomas K, et al. Biochemistry, 2015 Apr 21. PMID 25806409, Free PMC Article
  2. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. Albers E. IUBMB Life, 2009 Dec. PMID 19946895
  3. Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Gutierrez JA, et al. Nat Chem Biol, 2009 Apr. PMID 19270684, Free PMC Article
  4. Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Singh V, et al. Biochemistry, 2005 Sep 6. PMID 16128565
  5. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. Lee JE, et al. J Mol Biol, 2005 Sep 23. PMID 16109423

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transition-state analogue affinity and thermodynamics in mutant VcMTAN became even more unlike those of EcMTAN, the opposite of expectations from catalytic site similarity
    Title: Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
  2. Pfs and LuxS synthesize AI-2 in vitro from S-ribosylhomocysteine.
    Title: [Cloning and expression of luxS and pfs and in vitro biosynthesis autoinducer 2 of avian pathogenic Escherichia coli from Anhui Province].
  3. Pfs transcription is shown to rely on both sigma 70 and sigma 38 (rpoS), and the latter is subject to induction that increases pfs expression
    Title: Escherichia coli pfs transcription: regulation and proposed roles in autoinducer-2 synthesis and purine excretion.
  4. transition state structure investigated using multiple kinetic isotope effects and its geometric and electrostatic properties obtained using density functional methods
    Title: Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
NP_414701.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    178455..179153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414701.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414701.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7HSE6
    Conserved Domains (1) summary
    PRK05584
    Location:1 → 230
    PRK05584; 5'-methylthioadenosine/adenosylhomocysteine nucleosidase
Nucleotide Protein
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