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cadA lysine decarboxylase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948643, updated on 3-Dec-2024

Summary

Official Symbol
cadA
Official Full Name
lysine decarboxylase 1
Primary source
ECOCYC:EG10131
Locus tag
b4131
See related
ASAP:ABE-0013526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4125; ldcI
Summary
Induction of the cadAB operon under acidic conditions and in the presence of lycine neutralized extracellualr environment and enabled production of CO(2); production of cadaverine and aminopropylcadaverine instead of putrescine and spermidine also resulted. cadAB operon induction also generated a proton motive force. [More information is available at EcoGene: EG10131]. CadA, a lysine decarboxylase enzyme, is part of the lysine-dependent acid resistance system 4 (AR4) which confers resistance to weak organic acids produced during carbohydrate fermentation under conditions of anaerobiosis and phosphate starvation. [More information is available at EcoCyc: EG10131].
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Genomic context

Sequence:
NC_000913.3 (4356470..4358617, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase Neighboring gene dipeptide/tripeptide:H(+) symporter DtpC Neighboring gene lysine:cadaverine antiporter Neighboring gene DNA-binding transcriptional activator CadC

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxy-lyase activity  
enables guanosine tetraphosphate binding PubMed 
enables identical protein binding PubMed 
enables lysine decarboxylase activity PubMed 
enables lysine decarboxylase activity  
enables lysine decarboxylase activity PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in cytoplasm  

General protein information

Preferred Names
lysine decarboxylase 1
NP_418555.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4356470..4358617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418555.1 lysine decarboxylase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418555.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3P5DXD7, A0A478LL36
    Conserved Domains (1) summary
    PRK15400
    Location:1714
    PRK15400; lysine decarboxylase
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