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frdA fumarate reductase flavoprotein subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948667, updated on 25-Jan-2024

Summary

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Gene symbol
frdA
Gene description
fumarate reductase flavoprotein subunit
Primary source
ASAP:ABE-0013604
Locus tag
b4154
See related
ECOCYC:EG10330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4150
Summary
frdA transcription is repressed by nitrate via the NarXL system. [More information is available at EcoGene: EG10330]. FrdA is one of two catalytic subunits in the four subunit enzyme. [More information is available at EcoCyc: EG10330].
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Genomic context

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Sequence:
NC_000913.3 (4380510..4382318, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarate reductase membrane protein FrdD Neighboring gene fumarate reductase membrane protein FrdC Neighboring gene fumarate reductase iron-sulfur protein Neighboring gene EF-P-lysine lysyltransferase Neighboring gene putative transporter YjeM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A metabolic enzyme that rapidly produces superoxide, fumarate reductase of Escherichia coli. Imlay JA. J Biol Chem, 1995 Aug 25. PMID 7649986
  2. Genetic and physical characterization of lambda transducing phages (lambda frdA) containing the fumarate reductase gene of Escherichia coli K12. Cole ST, et al. Mol Gen Genet, 1980. PMID 6446651
  3. Identification of active site residues of Escherichia coli fumarate reductase by site-directed mutagenesis. Schröder I, et al. J Biol Chem, 1991 Jul 25. PMID 1856194
  4. Fumarate reductase of Escherichia coli. Elucidation of the covalent-flavin component. Weiner JH, et al. J Biol Chem, 1979 Sep 10. PMID 381310
  5. Heme biosynthesis is coupled to electron transport chains for energy generation. Möbius K, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20484676, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We demonstrate that the FAD assembly factor SdhE, which flavinylates and activates the respiratory enzyme succinate dehydrogenase (SDH), is also required for the complete activation and flavinylation of fumarate reductase .
    Title: The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.
  2. structural and catalytic analyses of the FrdA E49Q and SdhA Q50E mutants suggest that coulombic effects and the electronic state of the FAD are critical for directionality of the succinate/fumarate interconversions
    Title: Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in anaerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic respiration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anaerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bacterial-type flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in fermentation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fermentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane fumarate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane fumarate reductase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plasma membrane fumarate reductase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
fumarate reductase flavoprotein subunit
NP_418578.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4380510..4382318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418578.1 fumarate reductase flavoprotein subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418578.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3K0WAP0, A0A5B9AFI7, A0A8S7CWC2
    Conserved Domains (1) summary
    PRK09231
    Location:2 → 583
    PRK09231; fumarate reductase flavoprotein subunit; Validated
Nucleotide Protein
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