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idi isopentenyl-diphosphate Delta-isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949020, updated on 6-Oct-2023

Summary

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Gene symbol
idi
Gene description
isopentenyl-diphosphate Delta-isomerase
Primary source
ASAP:ABE-0009484
Locus tag
b2889
See related
ECOCYC:G7508
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2884; ygfV
Summary
The idi gene is nonessential. [More information is available at EcoGene: EG13072]. Isopentenyl diphosphate (IPP) isomerase (Idi) catalyzes the reversible isomerization of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP), a key step in the biosynthesis of isoprenoids. [More information is available at EcoCyc: G7508].
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Genomic context

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Sequence:
NC_000913.3 (3033065..3033613)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene urate:H(+) symporter Neighboring gene uncharacterized protein YqfG Neighboring gene protein YqfH Neighboring gene lysine--tRNA ligase Neighboring gene peptide chain release factor RF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli type I isopentenyl diphosphate isomerase: structural and catalytic roles for divalent metals. Lee S, et al. J Am Chem Soc, 2006 Sep 6. PMID 16939278
  2. Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography. de Ruyck J, et al. J Biol Chem, 2006 Jun 30. PMID 16617181
  3. Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate. Wu Z, et al. J Am Chem Soc, 2005 Dec 14. PMID 16332094, Free PMC Article
  4. A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase. Wouters J, et al. J Am Chem Soc, 2005 Jan 19. PMID 15643873
  5. Zinc is an essential cofactor for type I isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Carrigan CN, et al. J Am Chem Soc, 2003 Jul 30. PMID 15369345

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the importance of residue Tyr-104 for proper folding of Escherichia coli type I IPP isomerase
    Title: Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isopentenyl-diphosphate delta-isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dimethylallyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within isoprenoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
isopentenyl-diphosphate Delta-isomerase
NP_417365.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3033065..3033613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417365.1 isopentenyl-diphosphate Delta-isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417365.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6D0IDY7
    Conserved Domains (1) summary
    PRK03759
    Location:1 → 180
    PRK03759; isopentenyl-diphosphate Delta-isomerase
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials