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mak fructokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949086, updated on 2-May-2024

Summary

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Gene symbol
mak
Gene description
fructokinase
Primary source
ASAP:ABE-0001372
Locus tag
b0394
See related
ECOCYC:EG11288
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0389; yajF
Summary
Mak also has low level glucokinase activity; fructose is a much substrate than glucose in vitro. [More information is available at EcoGene: EG11288]. In the absence of the usual PTS-mediated route of fructose uptake, Mak catalyzes phosphorylation of fructose after its entry into the cell via PtsGF . [More information is available at EcoCyc: EG11288].
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Genomic context

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Sequence:
NC_000913.3 (410144..411052)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene protein YkiD Neighboring gene nucleoid-associated protein RdgC Neighboring gene putative transport protein AraJ Neighboring gene ATP-dependent structure-specific DNA nuclease - SbcC subunit Neighboring gene ATP-dependent structure-specific DNA nuclease - SbcD subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic control of manno(fructo)kinase activity in Escherichia coli. Sproul AA, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742072, Free PMC Article
  2. Purification and properties of the mannokinase from Escherichia coli. Sebastian J, et al. Arch Biochem Biophys, 1972 Jul. PMID 4557975
  3. Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Miller BG, et al. Biochemistry, 2005 Aug 16. PMID 16086580
  4. Facilitated diffusion of fructose via the phosphoenolpyruvate/glucose phosphotransferase system of Escherichia coli. Kornberg HL, et al. Proc Natl Acad Sci U S A, 2000 Feb 15. PMID 10677538, Free PMC Article
  5. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Miller BG, et al. Biochemistry, 2004 Jun 1. PMID 15157072

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fructokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fructokinase
NP_414928.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    410144..411052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414928.2 fructokinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414928.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X5F1, A0A8T3UGY4
    Conserved Domains (1) summary
    PRK09557
    Location:1 → 301
    PRK09557; fructokinase; Reviewed
Nucleotide Protein
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