Gene
apc
- ID
- ZDB-GENE-031112-7
- Name
- APC regulator of WNT signaling pathway
- Symbol
- apc Nomenclature History
- Previous Names
-
- cb965 (1)
- im:7150932
- im:7152872
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Involved in endocardial cushion morphogenesis; heart valve development; and somitogenesis. Acts upstream of with a positive effect on digestive tract development. Acts upstream of or within several processes, including digestive system development; regionalization; and sensory system development. Predicted to be located in several cellular components, including centrosome; kinetochore; and lateral plasma membrane. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Used to study familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb965 (9 images)
- IMAGE:7150932 (8 images)
- IMAGE:7152872 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 67 figures from 27 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu745 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ihb345 | Allele with one deletion | Exon 14 | Unknown | CRISPR | |
| ihb346 | Allele with one deletion | Exon 14 | Unknown | CRISPR | |
| ihb347 | Allele with one deletion | Exon 15 | Unknown | CRISPR | |
| sa61 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6136 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9511 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12033 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21628 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27530 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-apc | (2) | |
| CRISPR2-apc | Zebrafish Nomenclature Committee | |
| MO1-apc | N/A | (10) |
| MO2-apc | N/A | Paridaen et al., 2009 |
| MO3-apc | N/A | Sandoval et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| familial adenomatous polyposis 1 | Alliance | Adenoma, periampullary, somatic | 175100 |
| familial adenomatous polyposis 1 | Alliance | Adenomatous polyposis coli | 175100 |
| familial adenomatous polyposis 1 | Alliance | Brain tumor-polyposis syndrome 2 | 175100 |
| familial adenomatous polyposis 1 | Alliance | Gardner syndrome | 175100 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| familial adenomatous polyposis | apchu745/+; ia28Tg | standard conditions | Peron et al., 2020 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009232 | EB-1 binding |
| Domain | IPR009234 | Adenomatous polyposis coli protein basic domain |
| Domain | IPR032038 | Adenomatous polyposis coli, N-terminal dimerisation domain |
| Family | IPR026818 | Adenomatous polyposis coli (APC) family |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
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Domain Details Per Protein
| Protein | Length | Adenomatous polyposis coli (APC) family | Adenomatous polyposis coli (APC) repeat | Adenomatous polyposis coli, N-terminal dimerisation domain | Adenomatous polyposis coli protein | Adenomatous polyposis coli protein, 15 residue repeat | Adenomatous polyposis coli protein basic domain | Adenomatous polyposis coli protein repeat | APC, N-terminal coiled-coil domain superfamily | Armadillo | Armadillo-like helical | Armadillo-type fold | EB-1 binding | SAMP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IWH7
|
2754 | |||||||||||||
|
UniProtKB:A0A8M2B1L0
|
2745 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-238M11 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-190G7 | ZFIN Curated Data | |
| Encodes | EST | cb965 | Thisse et al., 2001 | |
| Encodes | EST | IMAGE:7150932 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7152872 | Thisse et al., 2004 | |
| Encodes | STS | zfish44906-1822h03.q1k |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143840 (1) | 9214 nt | ||
| Genomic | GenBank:CU861476 (2) | 86052 nt | ||
| Polypeptide | UniProtKB:A0A0R4IWH7 (1) | 2754 aa |
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Zhang, Z., Yang, C., Wang, Z., Guo, L., Xu, Y., Gao, C., Sun, Y., Zhang, Z., Peng, J., Hu, M., Jan Lo, L., Ma, Z., Chen, J. (2023) Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis. Cell death discovery. 9:227227
- Shull, L.C., Lencer, E.S., Kim, H.M., Goyama, S., Kurokawa, M., Costello, J.C., Jones, K., Artinger, K.B. (2022) PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development (Cambridge, England). 149(4):
- Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):
- Akieda, Y., Ogamino, S., Furuie, H., Ishitani, S., Akiyoshi, R., Nogami, J., Masuda, T., Shimizu, N., Ohkawa, Y., Ishitani, T. (2019) Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo. Nature communications. 10:4710
- Delacruz, R.G.C., Sandoval, I.T., Chang, K., Miller, B.N., Reyes-Uribe, L., Borras, E., Lynch, P.M., Taggart, M.W., Hawk, E.T., Vilar, E., Jones, D.A. (2019) Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. Oncotarget. 10:3939-3951
- Ren, J., Han, P., Ma, X., Farah, E.N., Bloomekatz, J., Zeng, X.I., Zhang, R., Swim, M.M., Witty, A.D., Knight, H.G., Deshpande, R., Xu, W., Yelon, D., Chen, S., Chi, N.C. (2019) Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes. Developmental Cell. 50(6):729-743.e5
- Sun, X., Zhang, R., Liu, M., Chen, H., Chen, L., Luo, F., Zhang, D., Huang, J., Li, F., Ni, Z., Qi, H., Su, N., Jin, M., Yang, J., Tan, Q., Du, X., Chen, B., Huang, H., Chen, S., Yin, L., Xu, X., Deng, C., Luo, L., Xie, Y., Chen, L. (2019) Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage-hair hypoplasia via enhanced Wnt/β-catenin signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 34(11):2101-2116
- Tang, D., He, Y., Li, W., Li, H. (2019) Wnt/β-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast. Experimental & molecular medicine. 51:58
- Huang, C.X., Huang, Y., Duan, X.K., Zhang, M., Tu, J.P., Liu, J.X., Liu, H., Chen, T.S., Wang, W.M., Wang, H.L. (2018) Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell death and differentiation. 26(8):1531-1544
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