Gene
dtx1
- ID
- ZDB-GENE-130503-1
- Name
- deltex 1, E3 ubiquitin ligase
- Symbol
- dtx1 Nomenclature History
- Previous Names
-
- zmp:0000001121
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of with a negative effect on Notch signaling pathway. Acts upstream of or within glial cell differentiation and neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in nervous system and spinal cord neural tube. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1).
- Genome Resources
-
- Alliance (1)
- Gene:101885597 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Cheng et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Cheng et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24768 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Deltex, C-terminal | Deltex, C-terminal domain superfamily | Deltex family | WWE domain | WWE domain, subgroup | WWE domain superfamily | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0U3RBN1
|
545 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Comparative Orthology
- Alliance
- Tsai, I.C., Adams, K.A., Tzeng, J.A., Shennib, O., Tan, P.L., Katsanis, N. (2019) Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. JCI insight. 4(22):
- Cheng, Y.C., Huang, Y.C., Yeh, T.H., Shih, H.Y., Lin, C.Y., Lin, S.J., Chiu, C.C., Huang, C.W., Jiang, Y.J. (2015) Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Development. 10:28
- Hsieh, F.Y., Ma, T.L., Shih, H.Y., Lin, S.J., Huang, C.W., Wang, H.Y., and Cheng, Y.C. (2013) Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Developmental Biology. 375(1):1-12
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