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Reduced circulating lipoprotein(a) concentration

MedGen UID:
1053686
Concept ID:
CN377353
Finding
HPO: HP:6000522

Definition

The concentration of lipoprotein(a) in the blood circulation is below the lower limit of normal. Lipoprotein(a), also known as apolipoprotein(A), is encoded by LPA (HGNC:6667). [from HPO]

Term Hierarchy

Recent clinical studies

Etiology

Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Schwartz GG, Ballantyne CM
Atherosclerosis 2022 May;349:110-122. doi: 10.1016/j.atherosclerosis.2022.04.020. PMID: 35606071
Santangelo G, Faggiano A, Bernardi N, Carugo S, Giammanco A, Faggiano P
Nutr Metab Cardiovasc Dis 2022 Feb;32(2):309-317. Epub 2021 Oct 27 doi: 10.1016/j.numecd.2021.10.015. PMID: 34893419
O'Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im K, Lira Pineda A, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS
Circulation 2019 Mar 19;139(12):1483-1492. doi: 10.1161/CIRCULATIONAHA.118.037184. PMID: 30586750
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998

Diagnosis

Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Ward NC, Watts GF, Bishop W, Colquhoun D, Hamilton-Craig C, Hare DL, Kangaharan N, Kostner KM, Kritharides L, O'Brien R, Mori TA, Nestel PJ, Nicholls SJ, Psaltis PJ, Raffoul N, White HD, Sullivan DR
Heart Lung Circ 2023 Mar;32(3):287-296. Epub 2023 Jan 25 doi: 10.1016/j.hlc.2022.11.015. PMID: 36707360
Durlach V, Bonnefont-Rousselot D, Boccara F, Varret M, Di-Filippo Charcosset M, Cariou B, Valero R, Charriere S, Farnier M, Morange PE, Meilhac O, Lambert G, Moulin P, Gillery P, Beliard-Lasserre S, Bruckert E, Carrié A, Ferrières J, Collet X, Chapman MJ, Anglés-Cano E
Arch Cardiovasc Dis 2021 Dec;114(12):828-847. Epub 2021 Nov 25 doi: 10.1016/j.acvd.2021.10.009. PMID: 34840125
Salas-Salvadó J, Márquez-Sandoval F, Bulló M
Crit Rev Food Sci Nutr 2006;46(6):479-88. doi: 10.1080/10408390600723953. PMID: 16864141
Gonbert S, Malinsky S, Sposito AC, Laouenan H, Doucet C, Chapman MJ, Thillet J
Atherosclerosis 2002 Oct;164(2):305-11. doi: 10.1016/s0021-9150(02)00072-2. PMID: 12204802

Therapy

Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2022 Nov 4;23(21) doi: 10.3390/ijms232113499. PMID: 36362288Free PMC Article
Di Fusco SA, Arca M, Scicchitano P, Alonzo A, Perone F, Gulizia MM, Gabrielli D, Oliva F, Imperoli G, Colivicchi F
Heart 2022 Dec 13;109(1):18-25. doi: 10.1136/heartjnl-2021-320708. PMID: 35288443
O'Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im K, Lira Pineda A, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS
Circulation 2019 Mar 19;139(12):1483-1492. doi: 10.1161/CIRCULATIONAHA.118.037184. PMID: 30586750
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998

Prognosis

Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Safarova MS, Moriarty PM
Curr Atheroscler Rep 2023 Jul;25(7):391-404. Epub 2023 Jun 5 doi: 10.1007/s11883-023-01113-2. PMID: 37273067
Durlach V, Bonnefont-Rousselot D, Boccara F, Varret M, Di-Filippo Charcosset M, Cariou B, Valero R, Charriere S, Farnier M, Morange PE, Meilhac O, Lambert G, Moulin P, Gillery P, Beliard-Lasserre S, Bruckert E, Carrié A, Ferrières J, Collet X, Chapman MJ, Anglés-Cano E
Arch Cardiovasc Dis 2021 Dec;114(12):828-847. Epub 2021 Nov 25 doi: 10.1016/j.acvd.2021.10.009. PMID: 34840125
O'Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im K, Lira Pineda A, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS
Circulation 2019 Mar 19;139(12):1483-1492. doi: 10.1161/CIRCULATIONAHA.118.037184. PMID: 30586750
Milionis HJ, Winder AF, Mikhailidis DP
J Clin Pathol 2000 Jul;53(7):487-96. doi: 10.1136/jcp.53.7.487. PMID: 10961170Free PMC Article

Clinical prediction guides

Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Chemello K, Blom DJ, Marais AD, Lambert G, Blanchard V
Curr Atheroscler Rep 2022 Jun;24(6):399-405. Epub 2022 Mar 30 doi: 10.1007/s11883-022-01016-8. PMID: 35355214
Santangelo G, Faggiano A, Bernardi N, Carugo S, Giammanco A, Faggiano P
Nutr Metab Cardiovasc Dis 2022 Feb;32(2):309-317. Epub 2021 Oct 27 doi: 10.1016/j.numecd.2021.10.015. PMID: 34893419
Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R
Mol Psychiatry 2020 Feb;25(2):275-282. Epub 2019 Oct 8 doi: 10.1038/s41380-019-0542-x. PMID: 31595035
Milionis HJ, Winder AF, Mikhailidis DP
J Clin Pathol 2000 Jul;53(7):487-96. doi: 10.1136/jcp.53.7.487. PMID: 10961170Free PMC Article

Recent systematic reviews

Dai H, Zhu Y, Chen Z, Yan R, Liu J, He Z, Zhang L, Zhang F, Yan S
Endokrynol Pol 2023;74(3):234-242. Epub 2023 Jun 19 doi: 10.5603/EP.a2023.0036. PMID: 37335067
Cao YX, Liu HH, Li S, Li JJ
Am J Cardiovasc Drugs 2019 Feb;19(1):87-97. doi: 10.1007/s40256-018-0303-2. PMID: 30229525
Salas-Salvadó J, Márquez-Sandoval F, Bulló M
Crit Rev Food Sci Nutr 2006;46(6):479-88. doi: 10.1080/10408390600723953. PMID: 16864141

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