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Abnormal circulating organic compound concentration

MedGen UID:
1052687
•Concept ID:
CN376481
•
Finding
HPO: HP:0430071

Definition

Any deviation of the concentration of an orrganic compound from the normal range. An organic compound is defined as any compound that contains a carbon atom. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating organic compound concentration

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Current concepts in diagnosis and treatment of venous malformations.
Judith N, Ulrike E, Siegmar R, Matthias N, Jürgen H
J Craniomaxillofac Surg 2014 Oct;42(7):1300-4. Epub 2014 Apr 1 doi: 10.1016/j.jcms.2014.03.014. PMID: 24969765
Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus.
Pai VB, Sakadjian A, Puthoff TD
Pharmacotherapy 2008 Sep;28(9):1162-82. doi: 10.1592/phco.28.9.1162. PMID: 18752387

Recent clinical studies

Etiology

Micronutrient Status in Adult Crohn's Disease during Clinical Remission: A Systematic Review.
McDonnell M, Sartain S, Westoby C, Katarachia V, Wootton SA, Cummings JRF
Nutrients 2023 Nov 14;15(22) doi: 10.3390/nu15224777. PMID: 38004171Free PMC Article
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Homocysteine, intracellular signaling and thrombotic disorders.
Dionisio N, Jardín I, Salido GM, Rosado JA
Curr Med Chem 2010;17(27):3109-19. doi: 10.2174/092986710791959783. PMID: 20629621

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Diabetes insipidus.
Blevins LS Jr, Wand GS
Crit Care Med 1992 Jan;20(1):69-79. doi: 10.1097/00003246-199201000-00019. PMID: 1729049

Therapy

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Concise review: methemoglobinemia.
Mansouri A, Lurie AA
Am J Hematol 1993 Jan;42(1):7-12. doi: 10.1002/ajh.2830420104. PMID: 8416301
Diabetes insipidus.
Blevins LS Jr, Wand GS
Crit Care Med 1992 Jan;20(1):69-79. doi: 10.1097/00003246-199201000-00019. PMID: 1729049
Dichloroacetate.
Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837

Prognosis

Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R, Derbyshire E, Schön C
Adv Nutr 2022 Dec 22;13(6):2445-2457. doi: 10.1093/advances/nmac082. PMID: 36041182Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Trimethylamine oxide: a potential target for heart failure therapy.
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Oxidative stress and cardiovascular complications in polycystic ovarian syndrome.
Hyderali BN, Mala K
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:15-22. Epub 2015 Jun 2 doi: 10.1016/j.ejogrb.2015.05.005. PMID: 26066290

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R, Derbyshire E, Schön C
Adv Nutr 2022 Dec 22;13(6):2445-2457. doi: 10.1093/advances/nmac082. PMID: 36041182Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Beta- and alpha-cell dysfunction in type 2 diabetes.
Del Prato S, Marchetti P
Horm Metab Res 2004 Nov-Dec;36(11-12):775-81. doi: 10.1055/s-2004-826163. PMID: 15655708
Carnitine function and requirements during the life cycle.
Rebouche CJ
FASEB J 1992 Dec;6(15):3379-86. PMID: 1464372

Recent systematic reviews

Micronutrient Status in Adult Crohn's Disease during Clinical Remission: A Systematic Review.
McDonnell M, Sartain S, Westoby C, Katarachia V, Wootton SA, Cummings JRF
Nutrients 2023 Nov 14;15(22) doi: 10.3390/nu15224777. PMID: 38004171Free PMC Article
Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R, Derbyshire E, Schön C
Adv Nutr 2022 Dec 22;13(6):2445-2457. doi: 10.1093/advances/nmac082. PMID: 36041182Free PMC Article
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.
Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

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