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Vaginal disorder

MedGen UID:
12042
•Concept ID:
C0042251
•
Disease or Syndrome
Synonym: Vaginal disease
SNOMED CT: Disorder of vagina (25658005); Vaginal disorder (25658005)
 
Monarch Initiative: MONDO:0001433

Definition

A non-neoplastic or neoplastic disorder that affects the vagina. Representative examples include vaginal infection, vaginal polyp, and vaginal squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal disorder

Professional guidelines

PubMed

Progresses in Nano-Enabled Platforms for the Treatment of Vaginal Disorders.
Patel R, Yadav BK, Patel G
Recent Pat Nanotechnol 2023;17(3):208-227. doi: 10.2174/1872210516666220628150447. PMID: 35762539
An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review.
Mendling W, Palmeira-de-Oliveira A, Biber S, Prasauskas V
Arch Gynecol Obstet 2019 Jul;300(1):1-6. Epub 2019 Apr 5 doi: 10.1007/s00404-019-05142-8. PMID: 30953190Free PMC Article
Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India.
Adhikari PP, Talukdar S, Borah A
J Ethnopharmacol 2018 Jan 10;210:386-407. Epub 2017 Jul 19 doi: 10.1016/j.jep.2017.07.024. PMID: 28733191

Recent clinical studies

Etiology

Cationic amphiphiles against Gardnerella vaginalis resistant strains and bacterial vaginosis-associated pathogens.
Weeks RM, Moretti A, Song S, Uhrich KE, Karlyshev AV, Chikindas ML
Pathog Dis 2019 Nov 1;77(8) doi: 10.1093/femspd/ftz059. PMID: 31603505Free PMC Article
An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review.
Mendling W, Palmeira-de-Oliveira A, Biber S, Prasauskas V
Arch Gynecol Obstet 2019 Jul;300(1):1-6. Epub 2019 Apr 5 doi: 10.1007/s00404-019-05142-8. PMID: 30953190Free PMC Article
Sexually transmitted infections: challenges ahead.
Unemo M, Bradshaw CS, Hocking JS, de Vries HJC, Francis SC, Mabey D, Marrazzo JM, Sonder GJB, Schwebke JR, Hoornenborg E, Peeling RW, Philip SS, Low N, Fairley CK
Lancet Infect Dis 2017 Aug;17(8):e235-e279. Epub 2017 Jul 9 doi: 10.1016/S1473-3099(17)30310-9. PMID: 28701272
Can one size fit all? Approach to bacterial vaginosis in sub-Saharan Africa.
Woodman Z
Ann Clin Microbiol Antimicrob 2016 Mar 11;15:16. doi: 10.1186/s12941-016-0132-6. PMID: 26968525Free PMC Article
Interleukin-6, interleukin-10 and interleukin-12 in vaginal fluid from women with bacterial vaginosis.
Weissenbacher T, Walter C, Mylonas I, Scholz C, Gingelmaier A, Friese K
Arch Gynecol Obstet 2010 Jan;281(1):77-80. Epub 2009 Apr 14 doi: 10.1007/s00404-009-1072-6. PMID: 19365635

Diagnosis

Sexually transmitted infections: challenges ahead.
Unemo M, Bradshaw CS, Hocking JS, de Vries HJC, Francis SC, Mabey D, Marrazzo JM, Sonder GJB, Schwebke JR, Hoornenborg E, Peeling RW, Philip SS, Low N, Fairley CK
Lancet Infect Dis 2017 Aug;17(8):e235-e279. Epub 2017 Jul 9 doi: 10.1016/S1473-3099(17)30310-9. PMID: 28701272
Can one size fit all? Approach to bacterial vaginosis in sub-Saharan Africa.
Woodman Z
Ann Clin Microbiol Antimicrob 2016 Mar 11;15:16. doi: 10.1186/s12941-016-0132-6. PMID: 26968525Free PMC Article
Reciprocal interference between Lactobacillus spp. and Gardnerella vaginalis on initial adherence to epithelial cells.
Castro J, Henriques A, Machado A, Henriques M, Jefferson KK, Cerca N
Int J Med Sci 2013;10(9):1193-8. Epub 2013 Jul 20 doi: 10.7150/ijms.6304. PMID: 23935396Free PMC Article
Composition of the vaginal microbiota in women of reproductive age--sensitive and specific molecular diagnosis of bacterial vaginosis is possible?
Shipitsyna E, Roos A, Datcu R, Hallén A, Fredlund H, Jensen JS, Engstrand L, Unemo M
PLoS One 2013;8(4):e60670. Epub 2013 Apr 9 doi: 10.1371/journal.pone.0060670. PMID: 23585843Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article

Therapy

An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review.
Mendling W, Palmeira-de-Oliveira A, Biber S, Prasauskas V
Arch Gynecol Obstet 2019 Jul;300(1):1-6. Epub 2019 Apr 5 doi: 10.1007/s00404-019-05142-8. PMID: 30953190Free PMC Article
Can one size fit all? Approach to bacterial vaginosis in sub-Saharan Africa.
Woodman Z
Ann Clin Microbiol Antimicrob 2016 Mar 11;15:16. doi: 10.1186/s12941-016-0132-6. PMID: 26968525Free PMC Article
Rifaximin modulates the vaginal microbiome and metabolome in women affected by bacterial vaginosis.
Laghi L, Picone G, Cruciani F, Brigidi P, Calanni F, Donders G, Capozzi F, Vitali B
Antimicrob Agents Chemother 2014 Jun;58(6):3411-20. Epub 2014 Apr 7 doi: 10.1128/AAC.02469-14. PMID: 24709255Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article
Efficacy of rifaximin vaginal tablets in treatment of bacterial vaginosis: a molecular characterization of the vaginal microbiota.
Cruciani F, Brigidi P, Calanni F, Lauro V, Tacchi R, Donders G, Peters K, Guaschino S, Vitali B
Antimicrob Agents Chemother 2012 Aug;56(8):4062-70. Epub 2012 May 14 doi: 10.1128/AAC.00061-12. PMID: 22585228Free PMC Article

Prognosis

Sexually transmitted infections: challenges ahead.
Unemo M, Bradshaw CS, Hocking JS, de Vries HJC, Francis SC, Mabey D, Marrazzo JM, Sonder GJB, Schwebke JR, Hoornenborg E, Peeling RW, Philip SS, Low N, Fairley CK
Lancet Infect Dis 2017 Aug;17(8):e235-e279. Epub 2017 Jul 9 doi: 10.1016/S1473-3099(17)30310-9. PMID: 28701272
Composition of the vaginal microbiota in women of reproductive age--sensitive and specific molecular diagnosis of bacterial vaginosis is possible?
Shipitsyna E, Roos A, Datcu R, Hallén A, Fredlund H, Jensen JS, Engstrand L, Unemo M
PLoS One 2013;8(4):e60670. Epub 2013 Apr 9 doi: 10.1371/journal.pone.0060670. PMID: 23585843Free PMC Article
Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents.
Royse KE, Kempf MC, McGwin G Jr, Wilson CM, Tang J, Shrestha S
J Reprod Immunol 2012 Dec;96(1-2):84-9. Epub 2012 Sep 28 doi: 10.1016/j.jri.2012.08.002. PMID: 23021866Free PMC Article

Clinical prediction guides

Biogenic Amines Increase the Odds of Bacterial Vaginosis and Affect the Growth of and Lactic Acid Production by Vaginal Lactobacillus spp.
Borgogna JC, Shardell MD, Grace SG, Santori EK, Americus B, Li Z, Ulanov A, Forney L, Nelson TM, Brotman RM, Ravel J, Yeoman CJ
Appl Environ Microbiol 2021 Apr 27;87(10) doi: 10.1128/AEM.03068-20. PMID: 33674429Free PMC Article
Quantitation of all Four Gardnerella vaginalis Clades Detects Abnormal Vaginal Microbiota Characteristic of Bacterial Vaginosis More Accurately than Putative G. vaginalis Sialidase A Gene Count.
Shipitsyna E, Krysanova A, Khayrullina G, Shalepo K, Savicheva A, Guschin A, Unemo M
Mol Diagn Ther 2019 Feb;23(1):139-147. doi: 10.1007/s40291-019-00382-5. PMID: 30721449Free PMC Article
Composition of the vaginal microbiota in women of reproductive age--sensitive and specific molecular diagnosis of bacterial vaginosis is possible?
Shipitsyna E, Roos A, Datcu R, Hallén A, Fredlund H, Jensen JS, Engstrand L, Unemo M
PLoS One 2013;8(4):e60670. Epub 2013 Apr 9 doi: 10.1371/journal.pone.0060670. PMID: 23585843Free PMC Article
Efficacy of rifaximin vaginal tablets in treatment of bacterial vaginosis: a molecular characterization of the vaginal microbiota.
Cruciani F, Brigidi P, Calanni F, Lauro V, Tacchi R, Donders G, Peters K, Guaschino S, Vitali B
Antimicrob Agents Chemother 2012 Aug;56(8):4062-70. Epub 2012 May 14 doi: 10.1128/AAC.00061-12. PMID: 22585228Free PMC Article
Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis.
Libby EK, Pascal KE, Mordechai E, Adelson ME, Trama JP
Microbes Infect 2008 Apr;10(4):439-46. Epub 2008 Jan 12 doi: 10.1016/j.micinf.2008.01.004. PMID: 18403235

Recent systematic reviews

Prevalence of bacterial vaginosis in pregnant and non-pregnant Iranian women: a systematic review and meta-analysis.
Sabour S, Arzanlou M, Vaez H, Rahimi G, Sahebkar A, Khademi F
Arch Gynecol Obstet 2018 May;297(5):1101-1113. Epub 2018 Feb 17 doi: 10.1007/s00404-018-4722-8. PMID: 29455377
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article

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