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Abnormal brain lactate level by MRS

MedGen UID:
1369712
•Concept ID:
C4476564
•
Finding
Synonym: Abnormal lactate level by magnetic resonance spectroscopy
 
HPO: HP:0025045

Definition

A deviation from normal of the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Conditions with this feature

COG8-congenital disorder of glycosylation
MedGen UID:
409971
•Concept ID:
C1970021
•
Disease or Syndrome
Syndrome with characteristics of severe psychomotor retardation, failure to thrive and intolerance to wheat and dairy products. So far, only two cases have been described. The disease is caused by mutations in the COG8 gene, which encodes a subunit of the COG complex. This complex is involved vesicle transport in the Golgi apparatus.
See: Condition Record
COG8-congenital disorder of glycosylation

Professional guidelines

PubMed

Value of diagnosis and differential diagnosis of MRI and MR spectroscopy in gliomatosis cerebri.
Yu A, Li K, Li H
Eur J Radiol 2006 Aug;59(2):216-21. doi: 10.1016/j.ejrad.2006.03.001. PMID: 16769190

Recent clinical studies

Etiology

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling.
Wang R, Hu B, Sun C, Geng D, Lin J, Li Y
Mitochondrion 2021 Jul;59:276-282. Epub 2021 Jun 27 doi: 10.1016/j.mito.2021.06.012. PMID: 34186261
Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Lactate detection by MRS in mitochondrial encephalopathy: optimization of technical parameters.
José da Rocha A, Túlio Braga F, Carlos Martins Maia A Jr, Jorge da Silva C, Toyama C, Pereira Pinto Gama H, Kok F, Rodrigues Gomes H
J Neuroimaging 2008 Jan;18(1):1-8. doi: 10.1111/j.1552-6569.2007.00205.x. PMID: 18190488
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Makoroff KL, Cecil KM, Care M, Ball WS Jr
Pediatr Radiol 2005 Jul;35(7):668-76. Epub 2005 Apr 14 doi: 10.1007/s00247-005-1441-7. PMID: 15830194

Diagnosis

Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study.
Rowland LM, Pradhan S, Korenic S, Wijtenburg SA, Hong LE, Edden RA, Barker PB
Transl Psychiatry 2016 Nov 29;6(11):e967. doi: 10.1038/tp.2016.239. PMID: 27898072Free PMC Article
Respiratory chain deficiencies.
Delonlay P, Rötig A, Sarnat HB
Handb Clin Neurol 2013;113:1651-66. doi: 10.1016/B978-0-444-59565-2.00033-2. PMID: 23622386
Lactate peak on brain MRS in children with syndromic mitochondrial diseases.
Chi CS, Lee HF, Tsai CR, Chen WS, Tung JN, Hung HC
J Chin Med Assoc 2011 Jul;74(7):305-9. Epub 2011 Jul 7 doi: 10.1016/j.jcma.2011.05.006. PMID: 21783095
Lactate detection by MRS in mitochondrial encephalopathy: optimization of technical parameters.
José da Rocha A, Túlio Braga F, Carlos Martins Maia A Jr, Jorge da Silva C, Toyama C, Pereira Pinto Gama H, Kok F, Rodrigues Gomes H
J Neuroimaging 2008 Jan;18(1):1-8. doi: 10.1111/j.1552-6569.2007.00205.x. PMID: 18190488
Value of diagnosis and differential diagnosis of MRI and MR spectroscopy in gliomatosis cerebri.
Yu A, Li K, Li H
Eur J Radiol 2006 Aug;59(2):216-21. doi: 10.1016/j.ejrad.2006.03.001. PMID: 16769190

Therapy

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Application of NMR spectroscopy to monitoring MELAS treatment: a case report.
Möller HE, Wiedermann D, Kurlemann G, Hilbich T, Schuierer G
Muscle Nerve 2002 Apr;25(4):593-600. doi: 10.1002/mus.10084. PMID: 11932978
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
Grachev ID, Swarnkar A, Szeverenyi NM, Ramachandran TS, Apkarian AV
J Neurochem 2001 Apr;77(1):292-303. doi: 10.1046/j.1471-4159.2001.t01-1-00238.x. PMID: 11279285
Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).
Nakamura S, Yoshinari M, Wakisaka M, Kodera H, Doi Y, Yoshizumi H, Asano T, Iwase M, Mihara F, Fujishima M
Diabetes Metab 2000 Nov;26(5):407-10. PMID: 11119021
Proton MR spectroscopy in a child with pyruvate dehydrogenase complex deficiency.
Rubio-Gozalbo ME, Heerschap A, Trijbels JM, De Meirleir L, Thijssen HO, Smeitink JA
Magn Reson Imaging 1999 Jul;17(6):939-44. doi: 10.1016/s0730-725x(99)00002-8. PMID: 10402601

Prognosis

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.
Emir UE, Larkin SJ, de Pennington N, Voets N, Plaha P, Stacey R, Al-Qahtani K, Mccullagh J, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O
Cancer Res 2016 Jan 1;76(1):43-9. Epub 2015 Dec 15 doi: 10.1158/0008-5472.CAN-15-0934. PMID: 26669865Free PMC Article
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Makoroff KL, Cecil KM, Care M, Ball WS Jr
Pediatr Radiol 2005 Jul;35(7):668-76. Epub 2005 Apr 14 doi: 10.1007/s00247-005-1441-7. PMID: 15830194
Development and applications of in vivo clinical magnetic resonance spectroscopy.
Cox IJ
Prog Biophys Mol Biol 1996;65(1-2):45-81. doi: 10.1016/s0079-6107(96)00006-5. PMID: 9029941

Clinical prediction guides

Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study.
Rowland LM, Pradhan S, Korenic S, Wijtenburg SA, Hong LE, Edden RA, Barker PB
Transl Psychiatry 2016 Nov 29;6(11):e967. doi: 10.1038/tp.2016.239. PMID: 27898072Free PMC Article
Magnetic resonance spectroscopy in migraine: what have we learned so far?
Reyngoudt H, Achten E, Paemeleire K
Cephalalgia 2012 Aug;32(11):845-59. Epub 2012 Jul 4 doi: 10.1177/0333102412452048. PMID: 22763498
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Makoroff KL, Cecil KM, Care M, Ball WS Jr
Pediatr Radiol 2005 Jul;35(7):668-76. Epub 2005 Apr 14 doi: 10.1007/s00247-005-1441-7. PMID: 15830194
Development and applications of in vivo clinical magnetic resonance spectroscopy.
Cox IJ
Prog Biophys Mol Biol 1996;65(1-2):45-81. doi: 10.1016/s0079-6107(96)00006-5. PMID: 9029941

Recent systematic reviews

Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.
Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D
Neuropsychopharmacology 2018 Jul;43(8):1681-1690. Epub 2018 Mar 14 doi: 10.1038/s41386-018-0041-9. PMID: 29581538Free PMC Article

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