U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal metabolic brain imaging by MRS

MedGen UID:
868370
•Concept ID:
C4022764
•
Finding
HPO: HP:0012705

Definition

An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Professional guidelines

PubMed

Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
The Combination of Metabolic Posterior Cingulate Cortical Abnormalities and Structural Asymmetries Improves the Differential Diagnosis Between Primary Progressive Aphasia and Alzheimer's Disease.
Mitolo M, Stanzani-Maserati M, Manners DN, Capellari S, Testa C, Talozzi L, Poda R, Oppi F, Evangelisti S, Gramegna LL, Magarelli S, Pantieri R, Liguori R, Lodi R, Tonon C
J Alzheimers Dis 2021;82(4):1467-1473. doi: 10.3233/JAD-210211. PMID: 34151798
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224

Recent clinical studies

Etiology

Magnetic resonance imaging and spectroscopy in late-onset GM2-gangliosidosis.
Rowe OE, Rangaprakash D, Weerasekera A, Godbole N, Haxton E, James PF, Stephen CD, Barry RL, Eichler FS, Ratai EM
Mol Genet Metab 2021 Aug;133(4):386-396. Epub 2021 Jun 24 doi: 10.1016/j.ymgme.2021.06.008. PMID: 34226107Free PMC Article
Eye movements and imaging in vestibular migraine.
ElSherif M, Reda MI, Saadallah H, Mourad M
Acta Otorrinolaringol Esp (Engl Ed) 2020 Jan-Feb;71(1):3-8. Epub 2019 Jan 22 doi: 10.1016/j.otorri.2018.10.001. PMID: 30678846
Role of cerebral glutamate in post-stroke epileptogenesis.
Nicolo JP, O'Brien TJ, Kwan P
Neuroimage Clin 2019;24:102069. Epub 2019 Nov 5 doi: 10.1016/j.nicl.2019.102069. PMID: 31795040Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Glutamate and psychosis risk.
Egerton A, Fusar-Poli P, Stone JM
Curr Pharm Des 2012;18(4):466-78. doi: 10.2174/138161212799316244. PMID: 22239577

Diagnosis

Neuroimaging in primary lateral sclerosis.
Pioro EP, Turner MR, Bede P
Amyotroph Lateral Scler Frontotemporal Degener 2020 Nov;21(sup1):18-27. doi: 10.1080/21678421.2020.1837176. PMID: 33602015
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
Inherited or acquired metabolic disorders.
Eichler F, Ratai E, Carroll JJ, Masdeu JC
Handb Clin Neurol 2016;135:603-636. doi: 10.1016/B978-0-444-53485-9.00029-5. PMID: 27432685
Respiratory chain deficiencies.
Delonlay P, Rötig A, Sarnat HB
Handb Clin Neurol 2013;113:1651-66. doi: 10.1016/B978-0-444-59565-2.00033-2. PMID: 23622386
Magnetic resonance spectroscopy.
Duncan JS
Epilepsia 1996 Jul;37(7):598-605. doi: 10.1111/j.1528-1157.1996.tb00622.x. PMID: 8681890

Therapy

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice.
McLoughlin HS, Gundry K, Rainwater O, Schuster KH, Wellik IG, Zalon AJ, Benneyworth MA, Eberly LE, Öz G
Ann Neurol 2023 Oct;94(4):658-671. Epub 2023 Aug 2 doi: 10.1002/ana.26713. PMID: 37243335Free PMC Article
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
Clinical Features of Machado-Joseph Disease.
Mendonça N, França MC Jr, Gonçalves AF, Januário C
Adv Exp Med Biol 2018;1049:255-273. doi: 10.1007/978-3-319-71779-1_13. PMID: 29427108

Prognosis

Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
MRI-based methods to detect placental and fetal brain abnormalities in utero.
Girardi G
J Reprod Immunol 2016 Apr;114:86-91. Epub 2015 Jul 2 doi: 10.1016/j.jri.2015.05.008. PMID: 26187242
Magnetic resonance spectroscopy: principles and applications in neurosurgery.
McLean MA, Cross JJ
Br J Neurosurg 2009 Feb;23(1):5-13. doi: 10.1080/02688690802491673. PMID: 19234903

Clinical prediction guides

Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
Clinical magnetic resonance spectroscopy of the central nervous system.
Ratai EM, Gilberto González R
Handb Clin Neurol 2016;135:93-116. doi: 10.1016/B978-0-444-53485-9.00005-2. PMID: 27432661
MRI-based methods to detect placental and fetal brain abnormalities in utero.
Girardi G
J Reprod Immunol 2016 Apr;114:86-91. Epub 2015 Jul 2 doi: 10.1016/j.jri.2015.05.008. PMID: 26187242
Magnetic resonance spectroscopy: principles and applications in neurosurgery.
McLean MA, Cross JJ
Br J Neurosurg 2009 Feb;23(1):5-13. doi: 10.1080/02688690802491673. PMID: 19234903

Recent systematic reviews

Aggression in borderline personality disorder: A systematic review of neuroimaging studies.
Chu J, Zheng K, Yi J
Prog Neuropsychopharmacol Biol Psychiatry 2022 Mar 8;113:110472. Epub 2021 Nov 4 doi: 10.1016/j.pnpbp.2021.110472. PMID: 34742774
Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.
Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D
Neuropsychopharmacology 2018 Jul;43(8):1681-1690. Epub 2018 Mar 14 doi: 10.1038/s41386-018-0041-9. PMID: 29581538Free PMC Article
Migraine and magnetic resonance spectroscopy: a systematic review.
Younis S, Hougaard A, Vestergaard MB, Larsson HBW, Ashina M
Curr Opin Neurol 2017 Jun;30(3):246-262. doi: 10.1097/WCO.0000000000000436. PMID: 28240609
Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation.
Salavati B, Rajji TK, Price R, Sun Y, Graff-Guerrero A, Daskalakis ZJ
Schizophr Bull 2015 Jan;41(1):44-56. Epub 2014 Sep 22 doi: 10.1093/schbul/sbu132. PMID: 25249654Free PMC Article
A systematic review of Magnetic Resonance Imaging and Spectroscopy in brain injury after drowning.
Nucci-da-Silva MP, Amaro E Jr
Brain Inj 2009 Aug;23(9):707-14. doi: 10.1080/02699050903123351. PMID: 19636995

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...