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Malignant Mixed Tumor of the Salivary Gland

MedGen UID:
138003
•Concept ID:
C0344459
•
Neoplastic Process
Synonyms: Cancer of salivary gland, mixed tumor; Malignant Mixed Cell Type Neoplasm of Salivary Gland; Malignant Mixed Cell Type Neoplasm of the Salivary Gland; Malignant Mixed Neoplasm of Salivary Gland; Malignant Mixed Neoplasm of the Salivary Gland; Malignant mixed salivary gland tumor; Malignant mixed tumor of salivary gland; Malignant Mixed Tumor of Salivary Gland; Malignant Salivary Gland Mixed Cell Type Neoplasm; Malignant Salivary Gland Mixed Cell Type Tumor; Malignant Salivary Gland Mixed Neoplasm; Malignant Salivary Gland Mixed Tumor; Mixed Malignant Neoplasm of Salivary Gland; Mixed Malignant Neoplasm of the Salivary Gland; Mixed Malignant Salivary Gland Neoplasm; Mixed Malignant Salivary Gland Tumor; Mixed Malignant Tumor of Salivary Gland; Mixed Malignant Tumor of the Salivary Gland; Mixed tumor, salivary gland type, malignant
SNOMED CT: Malignant mixed salivary gland tumor (8145008); Mixed tumor, salivary gland type, malignant (8145008); Malignant mixed tumor of salivary gland (425225007); Cancer of salivary gland, mixed tumor (425225007)

Definition

A malignant tumor arising from the salivary gland. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739
Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866
The use of radiation therapy in the management of minor salivary gland tumors.
Ellis ER, Million RR, Mendenhall WM, Parsons JT, Cassisi NJ
Int J Radiat Oncol Biol Phys 1988 Sep;15(3):613-7. doi: 10.1016/0360-3016(88)90302-1. PMID: 2843487

Recent clinical studies

Etiology

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.
Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA
Am J Otolaryngol 2021 Nov-Dec;42(6):103135. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103135. PMID: 34171696

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.
Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA
Am J Otolaryngol 2021 Nov-Dec;42(6):103135. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103135. PMID: 34171696
The morphological spectrum of salivary gland type tumours of the breast.
Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647
Myoepithelial Tumors: An Update.
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065

Therapy

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Chemotherapy for recurrent salivary gland malignancies: experience of the ENT Department of Turin University.
Airoldi M, Brando V, Giordano C, Gabriele P, Bussi M, Cortesina G
ORL J Otorhinolaryngol Relat Spec 1994 Mar-Apr;56(2):105-11. doi: 10.1159/000276620. PMID: 8177583
Cisplatin, epirubicin and 5-fluorouracil combination chemotherapy for recurrent carcinoma of the salivary gland.
Airoldi M, Pedani F, Brando V, Gabriele P, Giordano C
Tumori 1989 Jun 30;75(3):252-6. doi: 10.1177/030089168907500312. PMID: 2475951
Colony-forming assay of human salivary gland tumors. Applications for chemosensitivity and histogenetic studies.
Johns ME, Mills SE, Thompson KK
Arch Otolaryngol 1983 Nov;109(11):709-14. doi: 10.1001/archotol.1983.00800250003001. PMID: 6314953

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.
Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA
Am J Otolaryngol 2021 Nov-Dec;42(6):103135. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103135. PMID: 34171696
The morphological spectrum of salivary gland type tumours of the breast.
Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647
Myoepithelial Tumors: An Update.
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Salivary-type neoplasms of the breast and lung.
Bennett AK, Mills SE, Wick MR
Semin Diagn Pathol 2003 Nov;20(4):279-304. doi: 10.1053/j.semdp.2003.09.001. PMID: 14694981

Clinical prediction guides

Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review.
Wang W, Chen H, Guo H, Chen L, Zhu M, Zhu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31744. doi: 10.1097/MD.0000000000031744. PMID: 36397326Free PMC Article
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Expression of VEGF₁₆₅b, VEGFR1, VEGFR2 and CD34 in benign and malignant tumors of parotid glands.
Błochowiak KJ, Sokalski J, Bodnar MB, Trzybulska D, Marszałek AK, Witmanowski H
Adv Clin Exp Med 2018 Jan;27(1):83-90. doi: 10.17219/acem/64876. PMID: 29521047
Salivary-type neoplasms of the breast and lung.
Bennett AK, Mills SE, Wick MR
Semin Diagn Pathol 2003 Nov;20(4):279-304. doi: 10.1053/j.semdp.2003.09.001. PMID: 14694981
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

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