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Reduced brain glutamate level by MRS

MedGen UID:
1380742
Concept ID:
C4477012
Finding
HPO: HP:0031161

Definition

An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced brain glutamate level by MRS

Professional guidelines

PubMed

Pillinger T, Rogdaki M, McCutcheon RA, Hathway P, Egerton A, Howes OD
Psychopharmacology (Berl) 2019 Jul;236(7):1985-1997. Epub 2019 Feb 28 doi: 10.1007/s00213-019-5188-5. PMID: 30820633Free PMC Article
Njau S, Joshi SH, Espinoza R, Leaver AM, Vasavada M, Marquina A, Woods RP, Narr KL
J Psychiatry Neurosci 2017 Jan;42(1):6-16. doi: 10.1503/jpn.150177. PMID: 27327561Free PMC Article
Riese F, Gietl A, Zölch N, Henning A, O'Gorman R, Kälin AM, Leh SE, Buck A, Warnock G, Edden RA, Luechinger R, Hock C, Kollias S, Michels L
Neurobiol Aging 2015 Jan;36(1):53-9. Epub 2014 Jul 29 doi: 10.1016/j.neurobiolaging.2014.07.030. PMID: 25169676Free PMC Article

Recent clinical studies

Etiology

Ritter C, Buchmann A, Müller ST, Volleberg M, Haynes M, Ghisleni C, Noeske R, Tuura R, Hasler G
JAMA Psychiatry 2022 Dec 1;79(12):1209-1216. doi: 10.1001/jamapsychiatry.2022.3384. PMID: 36260322Free PMC Article
Vakulin A, Green MA, D'Rozario AL, Stevens D, Openshaw H, Bartlett D, Wong K, McEvoy RD, Grunstein RR, Rae CD
J Sleep Res 2022 Apr;31(2):e13482. Epub 2021 Sep 15 doi: 10.1111/jsr.13482. PMID: 34528315
Persson J, Wall A, Weis J, Gingnell M, Antoni G, Lubberink M, Bodén R
Psychiatry Res Neuroimaging 2021 Sep 30;315:111327. Epub 2021 Jul 1 doi: 10.1016/j.pscychresns.2021.111327. PMID: 34246046
Kozhuharova P, Diaconescu AO, Allen P
Psychopharmacology (Berl) 2021 Sep;238(9):2459-2470. Epub 2021 Jun 19 doi: 10.1007/s00213-021-05867-y. PMID: 34146134Free PMC Article
Puts NA, Ryan M, Oeltzschner G, Horska A, Edden RAE, Mahone EM
Psychiatry Res Neuroimaging 2020 Jul 30;301:111082. Epub 2020 May 18 doi: 10.1016/j.pscychresns.2020.111082. PMID: 32438277

Diagnosis

Ritter C, Buchmann A, Müller ST, Volleberg M, Haynes M, Ghisleni C, Noeske R, Tuura R, Hasler G
JAMA Psychiatry 2022 Dec 1;79(12):1209-1216. doi: 10.1001/jamapsychiatry.2022.3384. PMID: 36260322Free PMC Article
Pierce S, Kadlaskar G, Edmondson DA, McNally Keehn R, Dydak U, Keehn B
J Neurodev Disord 2021 Jan 6;13(1):5. doi: 10.1186/s11689-020-09351-0. PMID: 33407072Free PMC Article
Zhang Y, Shen J
J Magn Reson 2020 May;314:106732. Epub 2020 Apr 13 doi: 10.1016/j.jmr.2020.106732. PMID: 32361510Free PMC Article
Kolodny T, Schallmo MP, Gerdts J, Edden RAE, Bernier RA, Murray SO
Autism Res 2020 Jul;13(7):1111-1129. Epub 2020 Apr 16 doi: 10.1002/aur.2300. PMID: 32297709Free PMC Article
Zheng H, Yang W, Zhang B, Hua G, Wang S, Jia F, Guo G, Wang W, Quan D
J Affect Disord 2020 Mar 15;265:193-199. Epub 2020 Jan 15 doi: 10.1016/j.jad.2020.01.059. PMID: 32090741

Therapy

John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
Lengu K, Ryan S, Peltier SJ, Tyszkowski T, Kairys A, Giordani B, Hampstead BM
J Alzheimers Dis 2021;84(3):1091-1102. doi: 10.3233/JAD-201091. PMID: 34602464Free PMC Article
Schmitz B, Pflugrad H, Tryc AB, Lanfermann H, Jäckel E, Schrem H, Beneke J, Barg-Hock H, Klempnauer J, Weissenborn K, Ding XQ
Aliment Pharmacol Ther 2019 Jun;49(11):1431-1441. Epub 2019 Apr 21 doi: 10.1111/apt.15256. PMID: 31006881
Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG Jr
Drug Alcohol Depend 2015 Jul 1;152:47-56. Epub 2015 May 7 doi: 10.1016/j.drugalcdep.2015.04.023. PMID: 25986964Free PMC Article
Ruban A, Biton IE, Markovich A, Mirelman D
Int J Mol Sci 2015 Feb 2;16(2):3226-36. doi: 10.3390/ijms16023226. PMID: 25648322Free PMC Article

Prognosis

Lea-Carnall CA, El-Deredy W, Stagg CJ, Williams SR, Trujillo-Barreto NJ
Neuroimage 2023 Feb 1;266:119813. Epub 2022 Dec 14 doi: 10.1016/j.neuroimage.2022.119813. PMID: 36528313Free PMC Article
Hervella P, Alonso-Alonso ML, Pérez-Mato M, Rodríguez-Yáñez M, Arias-Rivas S, López-Dequidt I, Pumar JM, Sobrino T, Campos F, Castillo J, Iglesias-Rey R
BMC Neurol 2022 Jun 9;22(1):215. doi: 10.1186/s12883-022-02740-z. PMID: 35681147Free PMC Article
Hjelmervik H, Craven AR, Johnsen E, Kompus K, Bless JJ, Sinkeviciute I, Kroken RA, Løberg EM, Ersland L, Grüner R, Sommer IE, Hugdahl K
Brain Behav 2022 Jan;12(1):e2446. Epub 2021 Dec 7 doi: 10.1002/brb3.2446. PMID: 34874613Free PMC Article
Ousdal OT, Milde AM, Craven AR, Ersland L, Endestad T, Melinder A, Huys QJ, Hugdahl K
Psychol Med 2019 Aug;49(11):1822-1830. Epub 2018 Sep 18 doi: 10.1017/S0033291718002519. PMID: 30223909Free PMC Article
Caravaggio F, Nakajima S, Plitman E, Gerretsen P, Chung JK, Iwata Y, Graff-Guerrero A
Prog Neuropsychopharmacol Biol Psychiatry 2016 Feb 4;65:49-53. Epub 2015 Sep 1 doi: 10.1016/j.pnpbp.2015.08.013. PMID: 26334687Free PMC Article

Clinical prediction guides

Lea-Carnall CA, El-Deredy W, Stagg CJ, Williams SR, Trujillo-Barreto NJ
Neuroimage 2023 Feb 1;266:119813. Epub 2022 Dec 14 doi: 10.1016/j.neuroimage.2022.119813. PMID: 36528313Free PMC Article
Hjelmervik H, Craven AR, Johnsen E, Kompus K, Bless JJ, Sinkeviciute I, Kroken RA, Løberg EM, Ersland L, Grüner R, Sommer IE, Hugdahl K
Brain Behav 2022 Jan;12(1):e2446. Epub 2021 Dec 7 doi: 10.1002/brb3.2446. PMID: 34874613Free PMC Article
Zheng H, Yang W, Zhang B, Hua G, Wang S, Jia F, Guo G, Wang W, Quan D
J Affect Disord 2020 Mar 15;265:193-199. Epub 2020 Jan 15 doi: 10.1016/j.jad.2020.01.059. PMID: 32090741
Shukla DK, Wijtenburg SA, Chen H, Chiappelli JJ, Kochunov P, Hong LE, Rowland LM
Schizophr Bull 2019 Apr 25;45(3):647-658. doi: 10.1093/schbul/sby075. PMID: 29912445Free PMC Article
Caravaggio F, Nakajima S, Plitman E, Gerretsen P, Chung JK, Iwata Y, Graff-Guerrero A
Prog Neuropsychopharmacol Biol Psychiatry 2016 Feb 4;65:49-53. Epub 2015 Sep 1 doi: 10.1016/j.pnpbp.2015.08.013. PMID: 26334687Free PMC Article

Recent systematic reviews

Zahid U, Onwordi EC, Hedges EP, Wall MB, Modinos G, Murray RM, Egerton A
Neurosci Biobehav Rev 2023 Jan;144:105010. Epub 2022 Dec 19 doi: 10.1016/j.neubiorev.2022.105010. PMID: 36549375
Moriguchi S, Takamiya A, Noda Y, Horita N, Wada M, Tsugawa S, Plitman E, Sano Y, Tarumi R, ElSalhy M, Katayama N, Ogyu K, Miyazaki T, Kishimoto T, Graff-Guerrero A, Meyer JH, Blumberger DM, Daskalakis ZJ, Mimura M, Nakajima S
Mol Psychiatry 2019 Jul;24(7):952-964. Epub 2018 Oct 12 doi: 10.1038/s41380-018-0252-9. PMID: 30315224Free PMC Article
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Younis S, Hougaard A, Vestergaard MB, Larsson HBW, Ashina M
Curr Opin Neurol 2017 Jun;30(3):246-262. doi: 10.1097/WCO.0000000000000436. PMID: 28240609
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632

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