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Metastatic malignant neoplasm in the spinal cord

MedGen UID:
138075
•Concept ID:
C0347016
•
Neoplastic Process
Synonyms: Metastasis to Spinal Cord; Metastasis to spinal cord; metastasis to spinal cord; Metastatic Malignant Neoplasm in the Spinal Cord; metastatic malignant neoplasm in the spinal cord; Metastatic malignant neoplasm of spinal cord; Metastatic malignant neoplasm to spinal cord; Metastatic Malignant Neoplasm to the Spinal Cord; Metastatic malignant neoplasm to the spinal cord; Metastatic Neoplasm to the Spinal Cord; Metastatic neoplasm to the spinal cord; Metastatic Tumor to the Spinal Cord; Metastatic tumor to the spinal cord; Metastatic tumour to the spinal cord; Secondary malignant neoplasm of spinal cord; Secondary Malignant Neoplasm to the Spinal Cord; Secondary malignant neoplasm to the spinal cord; Secondary Malignant Tumor to the Spinal Cord; Secondary malignant tumor to the spinal cord; Secondary malignant tumour to the spinal cord
SNOMED CT: Metastasis to spinal cord (94600009); Secondary malignant neoplasm of spinal cord (94600009); Metastatic malignant neoplasm to spinal cord (94600009); Metastatic malignant neoplasm of spinal cord (94600009)
 
Monarch Initiative: MONDO:0044912

Definition

A malignant neoplasm that has spread to the spinal cord from another anatomic site or system. Representative examples include carcinoma, lymphoma, and melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic malignant neoplasm in the spinal cord

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Metastatic Spinal Cord Compression: Unraveling the Diagnostic and Therapeutic Challenges.
Boussios S, Cooke D, Hayward C, Kanellos FS, Tsiouris AK, Chatziantoniou AA, Zakynthinakis-Kyriakou N, Karathanasi A
Anticancer Res 2018 Sep;38(9):4987-4997. doi: 10.21873/anticanres.12817. PMID: 30194142
Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine.
Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A
Int J Radiat Oncol Biol Phys 2017 Jan 1;97(1):64-74. Epub 2016 Sep 17 doi: 10.1016/j.ijrobp.2016.09.014. PMID: 27843035Free PMC Article
Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey.
Redmond KJ, Lo SS, Soltys SG, Yamada Y, Barani IJ, Brown PD, Chang EL, Gerszten PC, Chao ST, Amdur RJ, De Salles AA, Guckenberger M, Teh BS, Sheehan J, Kersh CR, Fehlings MG, Sohn MJ, Chang UK, Ryu S, Gibbs IC, Sahgal A
J Neurosurg Spine 2017 Mar;26(3):299-306. Epub 2016 Nov 11 doi: 10.3171/2016.8.SPINE16121. PMID: 27834628Free PMC Article
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial.
Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B
Lancet 2005 Aug 20-26;366(9486):643-8. doi: 10.1016/S0140-6736(05)66954-1. PMID: 16112300

Diagnosis

Spinal Cord Neoplasms.
McFaline-Figueroa JR
Continuum (Minneap Minn) 2024 Feb 1;30(1):99-118. doi: 10.1212/CON.0000000000001375. PMID: 38330474
Metastatic spinal cord compression.
Patnaik S, Turner J, Inaparthy P, Kieffer WK
Br J Hosp Med (Lond) 2020 Apr 2;81(4):1-10. doi: 10.12968/hmed.2019.0399. PMID: 32339020
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
Oncologic Mechanical Emergencies.
Khan UA, Shanholtz CB, McCurdy MT
Hematol Oncol Clin North Am 2017 Dec;31(6):927-940. doi: 10.1016/j.hoc.2017.08.001. PMID: 29078930
Neoplastic myelopathy.
Nagpal S, Clarke JL
Semin Neurol 2012 Apr;32(2):137-45. Epub 2012 Sep 8 doi: 10.1055/s-0032-1322584. PMID: 22961188

Therapy

It's Time..
Johnstone C, Recht A
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):572-574. doi: 10.1016/j.ijrobp.2020.04.004. PMID: 32976786
Metastatic spinal cord compression.
Patnaik S, Turner J, Inaparthy P, Kieffer WK
Br J Hosp Med (Lond) 2020 Apr 2;81(4):1-10. doi: 10.12968/hmed.2019.0399. PMID: 32339020
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial.
Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B
Lancet 2005 Aug 20-26;366(9486):643-8. doi: 10.1016/S0140-6736(05)66954-1. PMID: 16112300

Prognosis

What Predicts the Prognosis of Spinal Metastases in Separation Surgery Procedures?
Gong Y, Hu J, Jiang L, Zhuang H, Wei F, Liu Z, Ni K, Bian W, Wu Y, Liu X
World Neurosurg 2021 Feb;146:e714-e723. Epub 2020 Nov 7 doi: 10.1016/j.wneu.2020.10.172. PMID: 33171322
Metastatic spinal cord compression: diagnosis and management.
Al-Qurainy R, Collis E
BMJ 2016 May 19;353:i2539. doi: 10.1136/bmj.i2539. PMID: 27199232
Spinal cord involvement in Behçet's disease.
Lee HS, Kim do Y, Shin HY, Choi YC, Kim SM
Mult Scler 2016 Jun;22(7):960-3. Epub 2015 Oct 19 doi: 10.1177/1352458515613642. PMID: 26480923
Malignant epidural spinal cord compression: the role of external beam radiotherapy.
Holt T, Hoskin P, Maranzano E, Sahgal A, Schild SE, Ryu S, Loblaw A
Curr Opin Support Palliat Care 2012 Mar;6(1):103-8. doi: 10.1097/SPC.0b013e32834de701. PMID: 22156794
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708

Clinical prediction guides

Electrochemotherapy in radiotherapy-resistant epidural spinal cord compression in metastatic cancer patients.
Deschamps F, Tselikas L, Yevich S, Bonnet B, Roux C, Kobe A, Besse B, Berthelot K, Gaudin A, Mir LM, de Baere T
Eur J Cancer 2023 Jun;186:62-68. Epub 2023 Mar 17 doi: 10.1016/j.ejca.2023.03.012. PMID: 37030078
Spinal Cord Stimulation in the Treatment of Cancer Pain: A Retrospective Review.
Crowther JE, Chen GH, Legler A, Gulati A
Neuromodulation 2022 Jul;25(5):693-699. Epub 2022 Apr 9 doi: 10.1016/j.neurom.2022.01.023. PMID: 35410770
Agreement in Metastatic Spinal Cord Compression.
Arana E, Kovacs FM, Royuela A, Asenjo B, Pérez-Ramírez Ú, Zamora J; Spanish Back Pain Research Network Task Force for the Improvement of Inter-Disciplinary Management of Spinal Metastasis
J Natl Compr Canc Netw 2016 Jan;14(1):70-6. Epub 2016 Jan 5 doi: 10.6004/jnccn.2016.0008. PMID: 26733556
Malignant epidural spinal cord compression: the role of external beam radiotherapy.
Holt T, Hoskin P, Maranzano E, Sahgal A, Schild SE, Ryu S, Loblaw A
Curr Opin Support Palliat Care 2012 Mar;6(1):103-8. doi: 10.1097/SPC.0b013e32834de701. PMID: 22156794
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708

Recent systematic reviews

Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis.
Quraishi NA, Palliyil N, Hassanin MA, D'Aquino D, Shetaiwi A, Walker D
Eur Spine J 2023 Dec;32(12):4306-4313. Epub 2023 Jun 20 doi: 10.1007/s00586-023-07820-3. PMID: 37338630
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
WITHDRAWN: Radioisotopes for metastatic bone pain.
Roqué I Figuls M, Martinez-Zapata MJ, Scott-Brown M, Alonso-Coello P
Cochrane Database Syst Rev 2017 Mar 23;3(3):CD003347. doi: 10.1002/14651858.CD003347.pub3. PMID: 28334435Free PMC Article
Interventions for the treatment of metastatic extradural spinal cord compression in adults.
George R, Jeba J, Ramkumar G, Chacko AG, Tharyan P
Cochrane Database Syst Rev 2015 Sep 4;2015(9):CD006716. doi: 10.1002/14651858.CD006716.pub3. PMID: 26337716Free PMC Article
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article

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