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Benign Squamous Cell Neoplasm

MedGen UID:
141634
•Concept ID:
C0474800
•
Neoplastic Process
Synonyms: Benign Epidermoid Cell Neoplasm; Benign Epidermoid Cell Tumor; Benign squamous cell tumor; Benign Squamous Cell Tumor
SNOMED CT: Benign squamous cell tumor (252994001)

Definition

A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Pterygium-The Good, the Bad, and the Ugly.
Van Acker SI, Van den Bogerd B, Haagdorens M, Siozopoulou V, Ní Dhubhghaill S, Pintelon I, Koppen C
Cells 2021 Jun 22;10(7) doi: 10.3390/cells10071567. PMID: 34206333Free PMC Article
Cutaneous Squamous Cell Carcinoma: From Biology to Therapy.
Corchado-Cobos R, García-Sancha N, González-Sarmiento R, Pérez-Losada J, Cañueto J
Int J Mol Sci 2020 Apr 22;21(8) doi: 10.3390/ijms21082956. PMID: 32331425Free PMC Article
Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings.
Doğan S, Vural A, Kahriman G, İmamoğlu H, Abdülrezzak Ü, Öztürk M
Braz J Otorhinolaryngol 2020 Jul-Aug;86(4):468-482. Epub 2019 Mar 16 doi: 10.1016/j.bjorl.2019.02.003. PMID: 30956151Free PMC Article
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Cutaneous squamous cell carcinoma: defining the high-risk variant.
Martorell-Calatayud A, Sanmartín Jimenez O, Cruz Mojarrieta J, Guillén Barona C
Actas Dermosifiliogr 2013 Jun;104(5):367-79. Epub 2013 May 14 doi: 10.1016/j.adengl.2011.12.012. PMID: 23683506

Diagnosis

Cutaneous Verrucous Carcinomas: A Review.
Ye Q, Jia M, Deng LJ, Fang S
J Cutan Med Surg 2023 Mar-Apr;27(2):150-156. Epub 2023 Feb 14 doi: 10.1177/12034754231155895. PMID: 36789508
Squamous Neoplasia in the Esophagus.
Savant D, Zhang Q, Yang Z
Arch Pathol Lab Med 2021 May 1;145(5):554-561. doi: 10.5858/arpa.2020-0058-RA. PMID: 32271610
Controversies in Oral and Maxillofacial Oncology.
Ettinger KS, Yetzer JG
Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):487-501. doi: 10.1016/j.coms.2017.07.004. PMID: 28987229
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma?
Mandrell JC, Santa Cruz D
Semin Diagn Pathol 2009 Aug;26(3):150-63. doi: 10.1053/j.semdp.2009.09.003. PMID: 20043514

Therapy

Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Keratoacanthoma: a distinct entity?
Gleich T, Chiticariu E, Huber M, Hohl D
Exp Dermatol 2016 Feb;25(2):85-91. Epub 2015 Dec 4 doi: 10.1111/exd.12880. PMID: 26476131
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM
Thyroid 2009 Nov;19(11):1167-214. doi: 10.1089/thy.2009.0110. PMID: 19860577
Malignant craniopharyngioma.
Kristopaitis T, Thomas C, Petruzzelli GJ, Lee JM
Arch Pathol Lab Med 2000 Sep;124(9):1356-60. doi: 10.5858/2000-124-1356-MC. PMID: 10975938
Tracheal tumors.
Mathisen DJ
Chest Surg Clin N Am 1996 Nov;6(4):875-98. PMID: 8934015

Prognosis

Immunohistochemistry and in situ hybridization for the diagnosis and classification of squamous lesions of the anogenital region.
Pirog EC
Semin Diagn Pathol 2015 Sep;32(5):409-18. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.015. PMID: 25862555
Bazex syndrome.
Rodrigues IA Jr, Gresta LT, Cruz RC, Carvalho GG, Moreira MH
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20132488. PMID: 24346922Free PMC Article
Surgical pathology of lung cancer.
Rezaei MK, Nolan NJ, Schwartz AM
Semin Respir Crit Care Med 2013 Dec;34(6):770-86. Epub 2013 Nov 20 doi: 10.1055/s-0033-1358558. PMID: 24258567
Cutaneous squamous cell carcinoma: defining the high-risk variant.
Martorell-Calatayud A, Sanmartín Jimenez O, Cruz Mojarrieta J, Guillén Barona C
Actas Dermosifiliogr 2013 Jun;104(5):367-79. Epub 2013 May 14 doi: 10.1016/j.adengl.2011.12.012. PMID: 23683506
Malignant craniopharyngioma.
Kristopaitis T, Thomas C, Petruzzelli GJ, Lee JM
Arch Pathol Lab Med 2000 Sep;124(9):1356-60. doi: 10.5858/2000-124-1356-MC. PMID: 10975938

Clinical prediction guides

Prediction of squamous cell carcinoma cases from squamous cell hyperplasia in throat lesions using CT radiomics model.
Khodrog OA, Cui F, Xu N, Han Q, Liu J, Gong T, Yuan Q
Saudi Med J 2021 Mar;42(3):284-292. doi: 10.15537/smj.2021.42.3.20200617. PMID: 33632907Free PMC Article
Oral leukoplakia and oral cavity squamous cell carcinoma.
Bewley AF, Farwell DG
Clin Dermatol 2017 Sep-Oct;35(5):461-467. Epub 2017 Jun 27 doi: 10.1016/j.clindermatol.2017.06.008. PMID: 28916027
Role of diffusion-weighted imaging in head and neck lesions: Pictorial review.
Bhatt N, Gupta N, Soni N, Hooda K, Sapire JM, Kumar Y
Neuroradiol J 2017 Aug;30(4):356-369. Epub 2017 Jun 19 doi: 10.1177/1971400917708582. PMID: 28627953Free PMC Article
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Recent systematic reviews

Head and neck cancer with synchronous nodules of the lung as a diagnostic and therapeutic challenge - A systematic review.
Müller M, Li J, Giger R, Elicin O
Oral Oncol 2023 Oct;145:106529. Epub 2023 Jul 26 doi: 10.1016/j.oraloncology.2023.106529. PMID: 37506514
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032
Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review.
Driessen JP, van Kempen PM, van der Heijden GJ, Philippens ME, Pameijer FA, Stegeman I, Terhaard CH, Janssen LM, Grolman W
Head Neck 2015 Mar;37(3):440-8. Epub 2014 Feb 12 doi: 10.1002/hed.23575. PMID: 24347513
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Zhang Y, Wang Y, Wan Z, Liu S, Cao Y, Zeng Z
PLoS One 2014;9(2):e90362. Epub 2014 Feb 27 doi: 10.1371/journal.pone.0090362. PMID: 24587339Free PMC Article

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