U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Disorder of periapical tissues of tooth

MedGen UID:
14679
•Concept ID:
C0031028
•
Disease or Syndrome
Synonyms: Disease, Periapical; Diseases, Periapical; Periapical Disease; Periapical Diseases
SNOMED CT: Periradicular disease (34282009); Disorder of periapical tissues of tooth (34282009)

Definition

Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT. [from MeSH]

Professional guidelines

PubMed

Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article
European Society of Endodontology position statement: Management of deep caries and the exposed pulp.
European Society of Endodontology (ESE) developed by:, Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, Krastl G, Dammaschke T, Fransson H, Markvart M, Zehnder M, Bjørndal L
Int Endod J 2019 Jul;52(7):923-934. doi: 10.1111/iej.13080. PMID: 30664240
Assessment of treatment failure in endodontic therapy.
Bergenholtz G
J Oral Rehabil 2016 Oct;43(10):753-8. Epub 2016 Aug 13 doi: 10.1111/joor.12423. PMID: 27519460

Recent clinical studies

Etiology

Pain and flare-up after endodontic treatment procedures.
Sipavičiūtė E, Manelienė R
Stomatologija 2014;16(1):25-30. PMID: 24824057
A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.
Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626
Outcome of secondary root canal treatment: a systematic review of the literature.
Ng YL, Mann V, Gulabivala K
Int Endod J 2008 Dec;41(12):1026-46. doi: 10.1111/j.1365-2591.2008.01484.x. PMID: 19133093
Factors affecting the long-term results of endodontic treatment.
Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204
Periapical surgery.
Hirsch JM, Ahlström U, Henrikson PA, Heyden G, Peterson LE
Int J Oral Surg 1979 Jun;8(3):173-85. doi: 10.1016/s0300-9785(79)80016-2. PMID: 118123

Diagnosis

Pharmacological Management of Acute Endodontic Pain.
Khan AA, Diogenes A
Drugs 2021 Sep;81(14):1627-1643. Epub 2021 Oct 7 doi: 10.1007/s40265-021-01564-4. PMID: 34618315
The many faces of periapical inflammation.
Boeddinghaus R, Whyte A
Clin Radiol 2020 Sep;75(9):675-687. Epub 2020 Jul 14 doi: 10.1016/j.crad.2020.06.009. PMID: 32680582
Interaction between endodontics and periodontics.
Rotstein I
Periodontol 2000 2017 Jun;74(1):11-39. doi: 10.1111/prd.12188. PMID: 28429484
Periapical actinomycosis.
Pasupathy SP, Chakravarthy D, Chanmougananda S, Nair PP
BMJ Case Rep 2012 Aug 1;2012 doi: 10.1136/bcr-2012-006218. PMID: 22854234Free PMC Article
AAE Consensus Conference on Diagnostic Terminology: background and perspectives.
Glickman GN
J Endod 2009 Dec;35(12):1619-20. doi: 10.1016/j.joen.2009.09.029. PMID: 19932336

Therapy

Pharmacological Management of Acute Endodontic Pain.
Khan AA, Diogenes A
Drugs 2021 Sep;81(14):1627-1643. Epub 2021 Oct 7 doi: 10.1007/s40265-021-01564-4. PMID: 34618315
Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981
Regenerative endodontics: a comprehensive review.
Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B
Int Endod J 2018 Dec;51(12):1367-1388. Epub 2018 Jun 11 doi: 10.1111/iej.12954. PMID: 29777616
Endodontic procedures for retreatment of periapical lesions.
Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881Free PMC Article
Pain and flare-up after endodontic treatment procedures.
Sipavičiūtė E, Manelienė R
Stomatologija 2014;16(1):25-30. PMID: 24824057

Prognosis

Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.
Niazi SA, Bakhsh A
Medicina (Kaunas) 2022 Jul 14;58(7) doi: 10.3390/medicina58070931. PMID: 35888650Free PMC Article
Endodontic medicine: connections between apical periodontitis and systemic diseases.
Segura-Egea JJ, Martín-González J, Castellanos-Cosano L
Int Endod J 2015 Oct;48(10):933-51. Epub 2015 Aug 3 doi: 10.1111/iej.12507. PMID: 26174809
A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.
Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626
Modern endodontic surgery concepts and practice: a review.
Kim S, Kratchman S
J Endod 2006 Jul;32(7):601-23. Epub 2006 May 6 doi: 10.1016/j.joen.2005.12.010. PMID: 16793466
Factors affecting the long-term results of endodontic treatment.
Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

Clinical prediction guides

Artificial intelligence for caries and periapical periodontitis detection.
Li S, Liu J, Zhou Z, Zhou Z, Wu X, Li Y, Wang S, Liao W, Ying S, Zhao Z
J Dent 2022 Jul;122:104107. Epub 2022 Mar 24 doi: 10.1016/j.jdent.2022.104107. PMID: 35341892
Present status and future directions: Microbiology of endodontic infections.
Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494
Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article
Modern endodontic surgery concepts and practice: a review.
Kim S, Kratchman S
J Endod 2006 Jul;32(7):601-23. Epub 2006 May 6 doi: 10.1016/j.joen.2005.12.010. PMID: 16793466
Factors affecting the long-term results of endodontic treatment.
Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

Recent systematic reviews

Deep learning for caries detection: A systematic review.
Mohammad-Rahimi H, Motamedian SR, Rohban MH, Krois J, Uribe SE, Mahmoudinia E, Rokhshad R, Nadimi M, Schwendicke F
J Dent 2022 Jul;122:104115. Epub 2022 Mar 30 doi: 10.1016/j.jdent.2022.104115. PMID: 35367318
Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981
The global prevalence of apical periodontitis: a systematic review and meta-analysis.
Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579
Oral manifestations of Diabetes Mellitus. A systematic review.
Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, Viñas M, López-López J
Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e586-e594. doi: 10.4317/medoral.21655. PMID: 28809366Free PMC Article
Endodontic procedures for retreatment of periapical lesions.
Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...