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Abnormal liver morphology

MedGen UID:
1616314
•Concept ID:
C4531031
•
Anatomical Abnormality
HPO: HP:0410042

Definition

Any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal liver morphology

Professional guidelines

PubMed

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia.
Faughnan ME, Mager JJ, Hetts SW, Palda VA, Lang-Robertson K, Buscarini E, Deslandres E, Kasthuri RS, Lausman A, Poetker D, Ratjen F, Chesnutt MS, Clancy M, Whitehead KJ, Al-Samkari H, Chakinala M, Conrad M, Cortes D, Crocione C, Darling J, de Gussem E, Derksen C, Dupuis-Girod S, Foy P, Geisthoff U, Gossage JR, Hammill A, Heimdal K, Henderson K, Iyer VN, Kjeldsen AD, Komiyama M, Korenblatt K, McDonald J, McMahon J, McWilliams J, Meek ME, Mei-Zahav M, Olitsky S, Palmer S, Pantalone R, Piccirillo JF, Plahn B, Porteous MEM, Post MC, Radovanovic I, Rochon PJ, Rodriguez-Lopez J, Sabba C, Serra M, Shovlin C, Sprecher D, White AJ, Winship I, Zarrabeitia R
Ann Intern Med 2020 Dec 15;173(12):989-1001. Epub 2020 Sep 8 doi: 10.7326/M20-1443. PMID: 32894695
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
Kwo PY, Cohen SM, Lim JK
Am J Gastroenterol 2017 Jan;112(1):18-35. Epub 2016 Dec 20 doi: 10.1038/ajg.2016.517. PMID: 27995906

Recent clinical studies

Etiology

Imaging features facilitate diagnosis of porto-sinusoidal vascular disorder.
Lampichler K, Semmler G, Wöran K, Simbrunner B, Jachs M, Hartl L, Bauer DJM, Balcar L, Burghart L, Trauner M, Tamandl D, Ba-Ssalamah A, Mandorfer M, Reiberger T, Scheiner B, Scharitzer M
Eur Radiol 2023 Feb;33(2):1422-1432. Epub 2022 Sep 27 doi: 10.1007/s00330-022-09132-4. PMID: 36166087Free PMC Article
Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance.
Poelzl G, Ess M, Mussner-Seeber C, Pachinger O, Frick M, Ulmer H
Eur J Clin Invest 2012 Feb;42(2):153-63. Epub 2011 Aug 2 doi: 10.1111/j.1365-2362.2011.02573.x. PMID: 21806605

Diagnosis

Imaging features facilitate diagnosis of porto-sinusoidal vascular disorder.
Lampichler K, Semmler G, Wöran K, Simbrunner B, Jachs M, Hartl L, Bauer DJM, Balcar L, Burghart L, Trauner M, Tamandl D, Ba-Ssalamah A, Mandorfer M, Reiberger T, Scheiner B, Scharitzer M
Eur Radiol 2023 Feb;33(2):1422-1432. Epub 2022 Sep 27 doi: 10.1007/s00330-022-09132-4. PMID: 36166087Free PMC Article
Liver fat imaging-a clinical overview of ultrasound, CT, and MR imaging.
Zhang YN, Fowler KJ, Hamilton G, Cui JY, Sy EZ, Balanay M, Hooker JC, Szeverenyi N, Sirlin CB
Br J Radiol 2018 Sep;91(1089):20170959. Epub 2018 Jun 6 doi: 10.1259/bjr.20170959. PMID: 29722568Free PMC Article
Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance.
Poelzl G, Ess M, Mussner-Seeber C, Pachinger O, Frick M, Ulmer H
Eur J Clin Invest 2012 Feb;42(2):153-63. Epub 2011 Aug 2 doi: 10.1111/j.1365-2362.2011.02573.x. PMID: 21806605
High-performance liquid chromatographic microassay for L-alanine:glyoxylate aminotransferase activity in human liver.
Petrarulo M, Pellegrino S, Marangella M, Cosseddu D, Linari F
Clin Chim Acta 1992 Jun 30;208(3):183-92. doi: 10.1016/0009-8981(92)90075-2. PMID: 1499137

Prognosis

Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance.
Poelzl G, Ess M, Mussner-Seeber C, Pachinger O, Frick M, Ulmer H
Eur J Clin Invest 2012 Feb;42(2):153-63. Epub 2011 Aug 2 doi: 10.1111/j.1365-2362.2011.02573.x. PMID: 21806605

Clinical prediction guides

Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice.
Wang G, He B, Hu W, Liu K, Gong X, Kou H, Guo Y, Wang H
Toxicology 2018 Sep 1;408:70-79. Epub 2018 Jul 7 doi: 10.1016/j.tox.2018.07.004. PMID: 29990518
Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance.
Poelzl G, Ess M, Mussner-Seeber C, Pachinger O, Frick M, Ulmer H
Eur J Clin Invest 2012 Feb;42(2):153-63. Epub 2011 Aug 2 doi: 10.1111/j.1365-2362.2011.02573.x. PMID: 21806605

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