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Chronic Lymphocytic Leukemia- Modified Rai Staging System

MedGen UID:
1647279
•Concept ID:
C4683619
•
Neoplastic Process

Definition

A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America. [from NCI]

Professional guidelines

PubMed

Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.
Cheson BD, Bennett JM, Rai KR, Grever MR, Kay NE, Schiffer CA, Oken MM, Keating MJ, Boldt DH, Kempin SJ
Am J Hematol 1988 Nov;29(3):152-63. doi: 10.1002/ajh.2830290307. PMID: 3189311

Recent clinical studies

Etiology

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis.
Bagheri M, Vosoughi T, Hosseinzadeh M, Saki N
BMC Res Notes 2020 Sep 3;13(1):412. doi: 10.1186/s13104-020-05243-7. PMID: 32883360Free PMC Article
Chronic Lymphocytic Leukemia Prognostic Index: A New Integrated Scoring System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia.
Li H, Yi SH, Xiong WJ, Liu HM, Lyu R, Wang TY, Liu W, Zhong SZ, Yu Z, Zou DH, Xu Y, An G, Li ZJ, Qiu LG
Chin Med J (Engl) 2017 Jan 20;130(2):135-142. doi: 10.4103/0366-6999.197978. PMID: 28091403Free PMC Article
Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.
Cheson BD, Bennett JM, Rai KR, Grever MR, Kay NE, Schiffer CA, Oken MM, Keating MJ, Boldt DH, Kempin SJ
Am J Hematol 1988 Nov;29(3):152-63. doi: 10.1002/ajh.2830290307. PMID: 3189311
Study design in chronic lymphocytic leukemia.
Cheson BD
Nouv Rev Fr Hematol (1978) 1988;30(5-6):407-10. PMID: 3065736
Staging of chronic lymphocytic leukemia.
Baccarani M, Cavo M, Gobbi M, Lauria F, Tura S
Blood 1982 Jun;59(6):1191-6. PMID: 7082822

Diagnosis

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis.
Bagheri M, Vosoughi T, Hosseinzadeh M, Saki N
BMC Res Notes 2020 Sep 3;13(1):412. doi: 10.1186/s13104-020-05243-7. PMID: 32883360Free PMC Article
Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia.
Abdelgader EA, Eltayeb NH, Eltahir TA, Altayeb OA, Fadul EA, Abdel Rahman EM, Merghani TH
BMC Res Notes 2018 Nov 15;11(1):815. doi: 10.1186/s13104-018-3926-0. PMID: 30442182Free PMC Article
Chronic Lymphocytic Leukemia Prognostic Index: A New Integrated Scoring System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia.
Li H, Yi SH, Xiong WJ, Liu HM, Lyu R, Wang TY, Liu W, Zhong SZ, Yu Z, Zou DH, Xu Y, An G, Li ZJ, Qiu LG
Chin Med J (Engl) 2017 Jan 20;130(2):135-142. doi: 10.4103/0366-6999.197978. PMID: 28091403Free PMC Article
Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.
Cheson BD, Bennett JM, Rai KR, Grever MR, Kay NE, Schiffer CA, Oken MM, Keating MJ, Boldt DH, Kempin SJ
Am J Hematol 1988 Nov;29(3):152-63. doi: 10.1002/ajh.2830290307. PMID: 3189311
Staging of chronic lymphocytic leukemia.
Baccarani M, Cavo M, Gobbi M, Lauria F, Tura S
Blood 1982 Jun;59(6):1191-6. PMID: 7082822

Therapy

Serum levels of soluble intercellular adhesion molecule 1 are increased in chronic B-lymphocytic leukemia and correlate with clinical stage and prognostic markers.
Christiansen I, Gidlöf C, Wallgren AC, Simonsson B, Tötterman TH
Blood 1994 Nov 1;84(9):3010-6. PMID: 7949173
Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.
Cheson BD, Bennett JM, Rai KR, Grever MR, Kay NE, Schiffer CA, Oken MM, Keating MJ, Boldt DH, Kempin SJ
Am J Hematol 1988 Nov;29(3):152-63. doi: 10.1002/ajh.2830290307. PMID: 3189311
Study design in chronic lymphocytic leukemia.
Cheson BD
Nouv Rev Fr Hematol (1978) 1988;30(5-6):407-10. PMID: 3065736

Prognosis

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis.
Bagheri M, Vosoughi T, Hosseinzadeh M, Saki N
BMC Res Notes 2020 Sep 3;13(1):412. doi: 10.1186/s13104-020-05243-7. PMID: 32883360Free PMC Article
Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia.
Abdelgader EA, Eltayeb NH, Eltahir TA, Altayeb OA, Fadul EA, Abdel Rahman EM, Merghani TH
BMC Res Notes 2018 Nov 15;11(1):815. doi: 10.1186/s13104-018-3926-0. PMID: 30442182Free PMC Article
Decision-tree approach to the immunophenotype-based prognosis of the B-cell chronic lymphocytic leukemia.
Masić N, Gagro A, Rabatić S, Sabioncello A, Dasić G, Jaksić B, Vitale B
Am J Hematol 1998 Oct;59(2):143-8. doi: 10.1002/(sici)1096-8652(199810)59:2<143::aid-ajh7>3.0.co;2-y. PMID: 9766799
Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.
Cheson BD, Bennett JM, Rai KR, Grever MR, Kay NE, Schiffer CA, Oken MM, Keating MJ, Boldt DH, Kempin SJ
Am J Hematol 1988 Nov;29(3):152-63. doi: 10.1002/ajh.2830290307. PMID: 3189311
Staging of chronic lymphocytic leukemia.
Baccarani M, Cavo M, Gobbi M, Lauria F, Tura S
Blood 1982 Jun;59(6):1191-6. PMID: 7082822

Clinical prediction guides

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis.
Bagheri M, Vosoughi T, Hosseinzadeh M, Saki N
BMC Res Notes 2020 Sep 3;13(1):412. doi: 10.1186/s13104-020-05243-7. PMID: 32883360Free PMC Article
Chronic Lymphocytic Leukemia Prognostic Index: A New Integrated Scoring System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia.
Li H, Yi SH, Xiong WJ, Liu HM, Lyu R, Wang TY, Liu W, Zhong SZ, Yu Z, Zou DH, Xu Y, An G, Li ZJ, Qiu LG
Chin Med J (Engl) 2017 Jan 20;130(2):135-142. doi: 10.4103/0366-6999.197978. PMID: 28091403Free PMC Article
Clinical significance of CD38 expression in chronic lymphocytic leukemia.
Del Poeta G, Maurillo L, Venditti A, Buccisano F, Epiceno AM, Capelli G, Tamburini A, Suppo G, Battaglia A, Del Principe MI, Del Moro B, Masi M, Amadori S
Blood 2001 Nov 1;98(9):2633-9. doi: 10.1182/blood.v98.9.2633. PMID: 11675331
The significance of the bone marrow biopsy pattern in chronic lymphocytic leukemia: a prognostic dilemma.
Zengin N, Kars A, Sungur A, Zengin NI, Hayran M, Tekuzman G, Kansu E, Ruacan S, Firat D
Am J Hematol 1999 Dec;62(4):208-11. doi: 10.1002/(sici)1096-8652(199912)62:4<208::aid-ajh2>3.0.co;2-e. PMID: 10589075
Decision-tree approach to the immunophenotype-based prognosis of the B-cell chronic lymphocytic leukemia.
Masić N, Gagro A, Rabatić S, Sabioncello A, Dasić G, Jaksić B, Vitale B
Am J Hematol 1998 Oct;59(2):143-8. doi: 10.1002/(sici)1096-8652(199810)59:2<143::aid-ajh7>3.0.co;2-y. PMID: 9766799

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