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Stage 0 Chronic Lymphocytic Leukemia

MedGen UID:
82964
•Concept ID:
C0278718
•
Neoplastic Process
Synonyms: Chronic Lymphocytic Leukemia Stage 0; CLL Stage 0; Stage 0 Chronic Lymphocytic Leukemia- Modified Rai Staging System; Stage 0 CLL

Definition

Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage 0 Chronic Lymphocytic Leukemia

Professional guidelines

PubMed

A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia.
D'Arena G, D'Auria F, Simeon V, Laurenti L, Deaglio S, Mansueto G, Del Principe MI, Statuto T, Pietrantuono G, Guariglia R, Innocenti I, Martorelli MC, Villani O, De Feo V, Del Poeta G, Musto P
Am J Hematol 2012 Jun;87(6):628-31. Epub 2012 Mar 28 doi: 10.1002/ajh.23170. PMID: 22460620

Recent clinical studies

Etiology

A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).
Molica S, Giannarelli D, Levato L, Mirabelli R, Gentile M, Lentini M, Morabito F
Int J Hematol 2014 Sep;100(3):290-5. Epub 2014 Jul 27 doi: 10.1007/s12185-014-1634-7. PMID: 25064370
Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.
Morabito F, Mosca L, Cutrona G, Agnelli L, Tuana G, Ferracin M, Zagatti B, Lionetti M, Fabris S, Maura F, Matis S, Gentile M, Vigna E, Colombo M, Massucco C, Recchia AG, Bossio S, De Stefano L, Ilariucci F, Musolino C, Molica S, Di Raimondo F, Cortelezzi A, Tassone P, Negrini M, Monti S, Rossi D, Gaidano G, Ferrarini M, Neri A
Clin Cancer Res 2013 Nov 1;19(21):5890-900. Epub 2013 Sep 13 doi: 10.1158/1078-0432.CCR-13-0622. PMID: 24036852
Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia.
Shanafelt TD, Rabe KG, Kay NE, Zent CS, Call TG, Slager SL, Bowen DA, Schwager SM, Nowakowski GS
Leuk Lymphoma 2010 Jul;51(7):1233-40. doi: 10.3109/10428194.2010.486877. PMID: 20496995Free PMC Article
Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia.
Shanafelt TD, Kay NE, Rabe KG, Call TG, Zent CS, Maddocks K, Jenkins G, Jelinek DF, Morice WG, Boysen J, Schwager S, Bowen D, Slager SL, Hanson CA
J Clin Oncol 2009 Aug 20;27(24):3959-63. Epub 2009 Jul 20 doi: 10.1200/JCO.2008.21.2704. PMID: 19620484Free PMC Article
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Muntañola A, Bosch F, Arguis P, Arellano-Rodrigo E, Ayuso C, Giné E, Crespo M, Abrisqueta P, Moreno C, Cobo F, López-Guillermo A, Montserrat E
J Clin Oncol 2007 Apr 20;25(12):1576-80. Epub 2007 Mar 12 doi: 10.1200/JCO.2006.08.4194. PMID: 17353549

Diagnosis

Optic Perineuritis Presenting as the Initial Manifestation of Central Nervous System Involvement in Rai Stage 0 Chronic Lymphocytic Leukemia.
Parker JL, Mays KM, Pratibhu PP, Pick PW, Block DK
J Neuroophthalmol 2022 Mar 1;42(1):e187-e191. Epub 2021 Jun 29 doi: 10.1097/WNO.0000000000001263. PMID: 35500239
A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).
Molica S, Giannarelli D, Levato L, Mirabelli R, Gentile M, Lentini M, Morabito F
Int J Hematol 2014 Sep;100(3):290-5. Epub 2014 Jul 27 doi: 10.1007/s12185-014-1634-7. PMID: 25064370
Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.
Morabito F, Mosca L, Cutrona G, Agnelli L, Tuana G, Ferracin M, Zagatti B, Lionetti M, Fabris S, Maura F, Matis S, Gentile M, Vigna E, Colombo M, Massucco C, Recchia AG, Bossio S, De Stefano L, Ilariucci F, Musolino C, Molica S, Di Raimondo F, Cortelezzi A, Tassone P, Negrini M, Monti S, Rossi D, Gaidano G, Ferrarini M, Neri A
Clin Cancer Res 2013 Nov 1;19(21):5890-900. Epub 2013 Sep 13 doi: 10.1158/1078-0432.CCR-13-0622. PMID: 24036852
Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia.
Shanafelt TD, Rabe KG, Kay NE, Zent CS, Call TG, Slager SL, Bowen DA, Schwager SM, Nowakowski GS
Leuk Lymphoma 2010 Jul;51(7):1233-40. doi: 10.3109/10428194.2010.486877. PMID: 20496995Free PMC Article
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Muntañola A, Bosch F, Arguis P, Arellano-Rodrigo E, Ayuso C, Giné E, Crespo M, Abrisqueta P, Moreno C, Cobo F, López-Guillermo A, Montserrat E
J Clin Oncol 2007 Apr 20;25(12):1576-80. Epub 2007 Mar 12 doi: 10.1200/JCO.2006.08.4194. PMID: 17353549

Therapy

A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).
Molica S, Giannarelli D, Levato L, Mirabelli R, Gentile M, Lentini M, Morabito F
Int J Hematol 2014 Sep;100(3):290-5. Epub 2014 Jul 27 doi: 10.1007/s12185-014-1634-7. PMID: 25064370
Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia.
Shanafelt TD, Rabe KG, Kay NE, Zent CS, Call TG, Slager SL, Bowen DA, Schwager SM, Nowakowski GS
Leuk Lymphoma 2010 Jul;51(7):1233-40. doi: 10.3109/10428194.2010.486877. PMID: 20496995Free PMC Article
Acute granulomatous interstitial nephritis secondary to bisphosphonate alendronate sodium.
Peña de la Vega L, Fervenza FC, Lager D, Habermann T, Leung N
Ren Fail 2005;27(4):485-9. doi: 10.1081/jdi-65397. PMID: 16060139

Prognosis

Optic Perineuritis Presenting as the Initial Manifestation of Central Nervous System Involvement in Rai Stage 0 Chronic Lymphocytic Leukemia.
Parker JL, Mays KM, Pratibhu PP, Pick PW, Block DK
J Neuroophthalmol 2022 Mar 1;42(1):e187-e191. Epub 2021 Jun 29 doi: 10.1097/WNO.0000000000001263. PMID: 35500239
A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).
Molica S, Giannarelli D, Levato L, Mirabelli R, Gentile M, Lentini M, Morabito F
Int J Hematol 2014 Sep;100(3):290-5. Epub 2014 Jul 27 doi: 10.1007/s12185-014-1634-7. PMID: 25064370
Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.
Morabito F, Mosca L, Cutrona G, Agnelli L, Tuana G, Ferracin M, Zagatti B, Lionetti M, Fabris S, Maura F, Matis S, Gentile M, Vigna E, Colombo M, Massucco C, Recchia AG, Bossio S, De Stefano L, Ilariucci F, Musolino C, Molica S, Di Raimondo F, Cortelezzi A, Tassone P, Negrini M, Monti S, Rossi D, Gaidano G, Ferrarini M, Neri A
Clin Cancer Res 2013 Nov 1;19(21):5890-900. Epub 2013 Sep 13 doi: 10.1158/1078-0432.CCR-13-0622. PMID: 24036852
Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia.
Shanafelt TD, Rabe KG, Kay NE, Zent CS, Call TG, Slager SL, Bowen DA, Schwager SM, Nowakowski GS
Leuk Lymphoma 2010 Jul;51(7):1233-40. doi: 10.3109/10428194.2010.486877. PMID: 20496995Free PMC Article
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Muntañola A, Bosch F, Arguis P, Arellano-Rodrigo E, Ayuso C, Giné E, Crespo M, Abrisqueta P, Moreno C, Cobo F, López-Guillermo A, Montserrat E
J Clin Oncol 2007 Apr 20;25(12):1576-80. Epub 2007 Mar 12 doi: 10.1200/JCO.2006.08.4194. PMID: 17353549

Clinical prediction guides

A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).
Molica S, Giannarelli D, Levato L, Mirabelli R, Gentile M, Lentini M, Morabito F
Int J Hematol 2014 Sep;100(3):290-5. Epub 2014 Jul 27 doi: 10.1007/s12185-014-1634-7. PMID: 25064370
Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.
Morabito F, Mosca L, Cutrona G, Agnelli L, Tuana G, Ferracin M, Zagatti B, Lionetti M, Fabris S, Maura F, Matis S, Gentile M, Vigna E, Colombo M, Massucco C, Recchia AG, Bossio S, De Stefano L, Ilariucci F, Musolino C, Molica S, Di Raimondo F, Cortelezzi A, Tassone P, Negrini M, Monti S, Rossi D, Gaidano G, Ferrarini M, Neri A
Clin Cancer Res 2013 Nov 1;19(21):5890-900. Epub 2013 Sep 13 doi: 10.1158/1078-0432.CCR-13-0622. PMID: 24036852
Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia.
Shanafelt TD, Rabe KG, Kay NE, Zent CS, Call TG, Slager SL, Bowen DA, Schwager SM, Nowakowski GS
Leuk Lymphoma 2010 Jul;51(7):1233-40. doi: 10.3109/10428194.2010.486877. PMID: 20496995Free PMC Article
Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia.
Shanafelt TD, Kay NE, Rabe KG, Call TG, Zent CS, Maddocks K, Jenkins G, Jelinek DF, Morice WG, Boysen J, Schwager S, Bowen D, Slager SL, Hanson CA
J Clin Oncol 2009 Aug 20;27(24):3959-63. Epub 2009 Jul 20 doi: 10.1200/JCO.2008.21.2704. PMID: 19620484Free PMC Article
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Muntañola A, Bosch F, Arguis P, Arellano-Rodrigo E, Ayuso C, Giné E, Crespo M, Abrisqueta P, Moreno C, Cobo F, López-Guillermo A, Montserrat E
J Clin Oncol 2007 Apr 20;25(12):1576-80. Epub 2007 Mar 12 doi: 10.1200/JCO.2006.08.4194. PMID: 17353549

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