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Recurrent Malignant Neoplasm of Multiple Primary Sites

MedGen UID:
1660725
•Concept ID:
C4725804
•
Neoplastic Process

Definition

Reemergence of a malignant neoplasm of multiple primary sites after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Neoplasm of Multiple Primary Sites

Professional guidelines

PubMed

Treatment of Oligometastatic Non-Small Cell Lung Cancer: An ASTRO/ESTRO Clinical Practice Guideline.
Iyengar P, All S, Berry MF, Boike TP, Bradfield L, Dingemans AC, Feldman J, Gomez DR, Hesketh PJ, Jabbour SK, Jeter M, Josipovic M, Lievens Y, McDonald F, Perez BA, Ricardi U, Ruffini E, De Ruysscher D, Saeed H, Schneider BJ, Senan S, Widder J, Guckenberger M
Pract Radiat Oncol 2023 Sep-Oct;13(5):393-412. Epub 2023 Apr 25 doi: 10.1016/j.prro.2023.04.004. PMID: 37294262
Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Circulating tumor cells in the diagnosis and management of pancreatic cancer.
Cen P, Ni X, Yang J, Graham DY, Li M
Biochim Biophys Acta 2012 Dec;1826(2):350-6. Epub 2012 Jun 7 doi: 10.1016/j.bbcan.2012.05.007. PMID: 22683404Free PMC Article

Recent clinical studies

Etiology

Efficacy and safety of single-agent belantamab mafodotin versus pomalidomide plus low-dose dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-3): a phase 3, open-label, randomised study.
Dimopoulos MA, Hungria VTM, Radinoff A, Delimpasi S, Mikala G, Masszi T, Li J, Capra M, Maiolino A, Pappa V, Chraniuk D, Osipov I, Leleu X, Low M, Matsumoto M, Sule N, Li M, McKeown A, He W, Bright S, Currie B, Perera S, Boyle J, Roy-Ghanta S, Opalinska J, Weisel K
Lancet Haematol 2023 Oct;10(10):e801-e812. doi: 10.1016/S2352-3026(23)00243-0. PMID: 37793771
Local Recurrence After Breast-Conserving Therapy in Patients With Multiple Ipsilateral Breast Cancer: Results From ACOSOG Z11102 (Alliance).
Boughey JC, Rosenkranz KM, Ballman KV, McCall L, Haffty BG, Cuttino LW, Kubicky CD, Le-Petross HT, Giuliano AE, Van Zee KJ, Hunt KK, Hahn OM, Carey LA, Partridge AH
J Clin Oncol 2023 Jun 10;41(17):3184-3193. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02553. PMID: 36977292Free PMC Article
Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.
Javle M, Borad MJ, Azad NS, Kurzrock R, Abou-Alfa GK, George B, Hainsworth J, Meric-Bernstam F, Swanton C, Sweeney CJ, Friedman CF, Bose R, Spigel DR, Wang Y, Levy J, Schulze K, Cuchelkar V, Patel A, Burris H
Lancet Oncol 2021 Sep;22(9):1290-1300. Epub 2021 Jul 30 doi: 10.1016/S1470-2045(21)00336-3. PMID: 34339623
Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): results from a randomised, multicentre, open-label, phase 3 study.
Dimopoulos M, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Yang H, Klippel Z, Zahlten-Kumeli A, Usmani SZ
Lancet 2020 Jul 18;396(10245):186-197. doi: 10.1016/S0140-6736(20)30734-0. PMID: 32682484
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Diagnosis

A B7-H4-Targeting Antibody-Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression.
Gitto SB, Whicker M, Davies G, Kumar S, Kinneer K, Xu H, Lewis A, Mamidi S, Medvedev S, Kim H, Anderton J, Tang EJ, Ferman B, Coats S, Wilkinson RW, Brown E, Powell DJ Jr, Simpkins F
Clin Cancer Res 2024 Apr 15;30(8):1567-1581. doi: 10.1158/1078-0432.CCR-23-1079. PMID: 37882675Free PMC Article
Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.
Norton JA, Fraker DL, Alexander HR, Jensen RT
Ann Surg 2012 Sep;256(3):509-17. doi: 10.1097/SLA.0b013e318265f08d. PMID: 22868363Free PMC Article
Parathyroid carcinoma.
Kebebew E
Curr Treat Options Oncol 2001 Aug;2(4):347-54. doi: 10.1007/s11864-001-0028-2. PMID: 12057115

Therapy

Efficacy and safety of single-agent belantamab mafodotin versus pomalidomide plus low-dose dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-3): a phase 3, open-label, randomised study.
Dimopoulos MA, Hungria VTM, Radinoff A, Delimpasi S, Mikala G, Masszi T, Li J, Capra M, Maiolino A, Pappa V, Chraniuk D, Osipov I, Leleu X, Low M, Matsumoto M, Sule N, Li M, McKeown A, He W, Bright S, Currie B, Perera S, Boyle J, Roy-Ghanta S, Opalinska J, Weisel K
Lancet Haematol 2023 Oct;10(10):e801-e812. doi: 10.1016/S2352-3026(23)00243-0. PMID: 37793771
Treatment of Oligometastatic Non-Small Cell Lung Cancer: An ASTRO/ESTRO Clinical Practice Guideline.
Iyengar P, All S, Berry MF, Boike TP, Bradfield L, Dingemans AC, Feldman J, Gomez DR, Hesketh PJ, Jabbour SK, Jeter M, Josipovic M, Lievens Y, McDonald F, Perez BA, Ricardi U, Ruffini E, De Ruysscher D, Saeed H, Schneider BJ, Senan S, Widder J, Guckenberger M
Pract Radiat Oncol 2023 Sep-Oct;13(5):393-412. Epub 2023 Apr 25 doi: 10.1016/j.prro.2023.04.004. PMID: 37294262
Local Recurrence After Breast-Conserving Therapy in Patients With Multiple Ipsilateral Breast Cancer: Results From ACOSOG Z11102 (Alliance).
Boughey JC, Rosenkranz KM, Ballman KV, McCall L, Haffty BG, Cuttino LW, Kubicky CD, Le-Petross HT, Giuliano AE, Van Zee KJ, Hunt KK, Hahn OM, Carey LA, Partridge AH
J Clin Oncol 2023 Jun 10;41(17):3184-3193. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02553. PMID: 36977292Free PMC Article
Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.
Javle M, Borad MJ, Azad NS, Kurzrock R, Abou-Alfa GK, George B, Hainsworth J, Meric-Bernstam F, Swanton C, Sweeney CJ, Friedman CF, Bose R, Spigel DR, Wang Y, Levy J, Schulze K, Cuchelkar V, Patel A, Burris H
Lancet Oncol 2021 Sep;22(9):1290-1300. Epub 2021 Jul 30 doi: 10.1016/S1470-2045(21)00336-3. PMID: 34339623
Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): results from a randomised, multicentre, open-label, phase 3 study.
Dimopoulos M, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Yang H, Klippel Z, Zahlten-Kumeli A, Usmani SZ
Lancet 2020 Jul 18;396(10245):186-197. doi: 10.1016/S0140-6736(20)30734-0. PMID: 32682484

Prognosis

Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.
Javle M, Borad MJ, Azad NS, Kurzrock R, Abou-Alfa GK, George B, Hainsworth J, Meric-Bernstam F, Swanton C, Sweeney CJ, Friedman CF, Bose R, Spigel DR, Wang Y, Levy J, Schulze K, Cuchelkar V, Patel A, Burris H
Lancet Oncol 2021 Sep;22(9):1290-1300. Epub 2021 Jul 30 doi: 10.1016/S1470-2045(21)00336-3. PMID: 34339623
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Once weekly versus twice weekly carfilzomib dosing in patients with relapsed and refractory multiple myeloma (A.R.R.O.W.): interim analysis results of a randomised, phase 3 study.
Moreau P, Mateos MV, Berenson JR, Weisel K, Lazzaro A, Song K, Dimopoulos MA, Huang M, Zahlten-Kumeli A, Stewart AK
Lancet Oncol 2018 Jul;19(7):953-964. Epub 2018 Jun 1 doi: 10.1016/S1470-2045(18)30354-1. PMID: 29866475
Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.
Norton JA, Fraker DL, Alexander HR, Jensen RT
Ann Surg 2012 Sep;256(3):509-17. doi: 10.1097/SLA.0b013e318265f08d. PMID: 22868363Free PMC Article
Parathyroid carcinoma.
Kebebew E
Curr Treat Options Oncol 2001 Aug;2(4):347-54. doi: 10.1007/s11864-001-0028-2. PMID: 12057115

Clinical prediction guides

Multiple Origin and Tumor Heterogeneity of Prostatic Ductal Adenocarcinoma in the Han Chinese Population.
Zhang W, Su F, Wang M, Hou H, Liu M, Liu D, Liu H
Genet Test Mol Biomarkers 2021 Nov;25(11):727-732. doi: 10.1089/gtmb.2021.0126. PMID: 34788144
Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.
Javle M, Borad MJ, Azad NS, Kurzrock R, Abou-Alfa GK, George B, Hainsworth J, Meric-Bernstam F, Swanton C, Sweeney CJ, Friedman CF, Bose R, Spigel DR, Wang Y, Levy J, Schulze K, Cuchelkar V, Patel A, Burris H
Lancet Oncol 2021 Sep;22(9):1290-1300. Epub 2021 Jul 30 doi: 10.1016/S1470-2045(21)00336-3. PMID: 34339623
Progression signature underlies clonal evolution and dissemination of multiple myeloma.
Shen YJ, Mishima Y, Shi J, Sklavenitis-Pistofidis R, Redd RA, Moschetta M, Manier S, Roccaro AM, Sacco A, Tai YT, Mercier F, Kawano Y, Su NK, Berrios B, Doench JG, Root DE, Michor F, Scadden DT, Ghobrial IM
Blood 2021 Apr 29;137(17):2360-2372. doi: 10.1182/blood.2020005885. PMID: 33150374Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Clinical Pattern of Recurrent Disease during the Follow-Up of Rectal Carcinoma.
Wieldraaijer T, Bruin P, Duineveld LAM, Tanis PJ, Smits AB, van Weert HCPM, Wind J
Dig Surg 2018;35(1):35-41. Epub 2017 Mar 14 doi: 10.1159/000464358. PMID: 28288461Free PMC Article

Recent systematic reviews

Microwave coagulation for liver metastases.
Storman D, Swierz MJ, Mitus JW, Pedziwiatr M, Liang N, Wolff R, Bala MM
Cochrane Database Syst Rev 2024 Mar 27;3(3):CD010163. doi: 10.1002/14651858.CD010163.pub3. PMID: 38534000Free PMC Article
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Pedziwiatr M, Mitus JW, Storman D, Swierz MJ, Kleijnen J
Cochrane Database Syst Rev 2019 Jul 10;7(7):CD009058. doi: 10.1002/14651858.CD009058.pub3. PMID: 31291464Free PMC Article
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609
Follow-up for women after treatment for cervical cancer: a systematic review.
Elit L, Fyles AW, Devries MC, Oliver TK, Fung-Kee-Fung M; Gynecology Cancer Disease Site Group
Gynecol Oncol 2009 Sep;114(3):528-35. Epub 2009 Jun 26 doi: 10.1016/j.ygyno.2009.06.001. PMID: 19560188

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