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Increased blood folate concentration

MedGen UID:
1704255
•Concept ID:
C5139164
•
Finding
HPO: HP:0032164

Definition

An elevated circulating concentration of folic acid, which is also known as vitamin B9. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased blood folate concentration

Professional guidelines

PubMed

The role of biofactors in the prevention and treatment of age-related diseases.
Frank J, Kisters K, Stirban OA, Obeid R, Lorkowski S, Wallert M, Egert S, Podszun MC, Eckert GP, Pettersen JA, Venturelli S, Classen HG, Golombek J
Biofactors 2021 Jul;47(4):522-550. Epub 2021 Mar 26 doi: 10.1002/biof.1728. PMID: 33772908
Targeting MTHFR for the treatment of migraines.
Rainero I, Vacca A, Roveta F, Govone F, Gai A, Rubino E
Expert Opin Ther Targets 2019 Jan;23(1):29-37. Epub 2018 Nov 28 doi: 10.1080/14728222.2019.1549544. PMID: 30451038
MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?
Reilly R, McNulty H, Pentieva K, Strain JJ, Ward M
Proc Nutr Soc 2014 Feb;73(1):47-56. Epub 2013 Oct 17 doi: 10.1017/S0029665113003613. PMID: 24131523

Recent clinical studies

Etiology

Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics: A Systematic Review and Meta-Analysis.
Hoek J, Steegers-Theunissen RPM, Willemsen SP, Schoenmakers S
Mol Nutr Food Res 2020 May;64(9):e1900696. Epub 2020 Feb 20 doi: 10.1002/mnfr.201900696. PMID: 32032459Free PMC Article
Folate levels in pregnancy and offspring food allergy and eczema.
Molloy J, Collier F, Saffery R, Allen KJ, Koplin JJ, Louise Ponsonby A, Tang MLK, Ward AC, Martino D, Burgner D, Carlin JB, Ranganathan S, Symeonedies C, Dwyer T; BIS Investigator Group, Vuillermin P
Pediatr Allergy Immunol 2020 Jan;31(1):38-46. Epub 2019 Oct 24 doi: 10.1111/pai.13128. PMID: 31566807
Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
Pietrzik K, Bailey L, Shane B
Clin Pharmacokinet 2010 Aug;49(8):535-48. doi: 10.2165/11532990-000000000-00000. PMID: 20608755
Folate status assessment.
Bailey LB
J Nutr 1990 Nov;120 Suppl 11:1508-11. doi: 10.1093/jn/120.suppl_11.1508. PMID: 2243297

Diagnosis

Folate concentrations and serum perfluoroalkyl and polyfluoroalkyl substance concentrations in adolescents and adults in the USA (National Health and Nutrition Examination Study 2003-16): an observational study.
Zhang Y, Mustieles V, Wang YX, Sun Y, Agudelo J, Bibi Z, Torres N, Oulhote Y, Slitt A, Messerlian C
Lancet Planet Health 2023 Jun;7(6):e449-e458. doi: 10.1016/S2542-5196(23)00088-8. PMID: 37286242Free PMC Article
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial.
Lamarca A, Palmer DH, Wasan HS, Ross PJ, Ma YT, Arora A, Falk S, Gillmore R, Wadsley J, Patel K, Anthoney A, Maraveyas A, Iveson T, Waters JS, Hobbs C, Barber S, Ryder WD, Ramage J, Davies LM, Bridgewater JA, Valle JW; Advanced Biliary Cancer Working Group
Lancet Oncol 2021 May;22(5):690-701. Epub 2021 Mar 30 doi: 10.1016/S1470-2045(21)00027-9. PMID: 33798493Free PMC Article
Methanol poisoning.
Kruse JA
Intensive Care Med 1992;18(7):391-7. doi: 10.1007/BF01694340. PMID: 1469176

Therapy

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Multivitamin/mineral supplements: Rationale and safety.
Biesalski HK, Tinz J
Nutrition 2017 Apr;36:60-66. Epub 2016 Jun 16 doi: 10.1016/j.nut.2016.06.003. PMID: 28336109
Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
Pietrzik K, Bailey L, Shane B
Clin Pharmacokinet 2010 Aug;49(8):535-48. doi: 10.2165/11532990-000000000-00000. PMID: 20608755
Folate status assessment.
Bailey LB
J Nutr 1990 Nov;120 Suppl 11:1508-11. doi: 10.1093/jn/120.suppl_11.1508. PMID: 2243297

Prognosis

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial.
Lamarca A, Palmer DH, Wasan HS, Ross PJ, Ma YT, Arora A, Falk S, Gillmore R, Wadsley J, Patel K, Anthoney A, Maraveyas A, Iveson T, Waters JS, Hobbs C, Barber S, Ryder WD, Ramage J, Davies LM, Bridgewater JA, Valle JW; Advanced Biliary Cancer Working Group
Lancet Oncol 2021 May;22(5):690-701. Epub 2021 Mar 30 doi: 10.1016/S1470-2045(21)00027-9. PMID: 33798493Free PMC Article
Effect of two different sublingual dosages of vitamin B(12) on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial.
Del Bo' C, Riso P, Gardana C, Brusamolino A, Battezzati A, Ciappellano S
Clin Nutr 2019 Apr;38(2):575-583. Epub 2018 Feb 15 doi: 10.1016/j.clnu.2018.02.008. PMID: 29499976
Preventing and Managing Toxicities of High-Dose Methotrexate.
Howard SC, McCormick J, Pui CH, Buddington RK, Harvey RD
Oncologist 2016 Dec;21(12):1471-1482. Epub 2016 Aug 5 doi: 10.1634/theoncologist.2015-0164. PMID: 27496039Free PMC Article
Methanol poisoning.
Kruse JA
Intensive Care Med 1992;18(7):391-7. doi: 10.1007/BF01694340. PMID: 1469176

Clinical prediction guides

Association between red blood cell folate and Trichomonas vaginalis infection among women.
Liao WZ, Zhou ZY, Mao JH, Wang ZX, Hu YM, Lou YF, Zheng QR, Guo XG
BMC Infect Dis 2023 Jan 23;23(1):48. doi: 10.1186/s12879-022-07950-x. PMID: 36690944Free PMC Article
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Associations of single and multiple perfluoroalkyl substances exposure with folate among adolescents in NHANES 2007-2010.
Tian Y, Luan M, Zhang J, Yang H, Wang Y, Chen H
Chemosphere 2022 Nov;307(Pt 3):135995. Epub 2022 Aug 15 doi: 10.1016/j.chemosphere.2022.135995. PMID: 35981617
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Folate and B12 in prostate cancer.
Collin SM
Adv Clin Chem 2013;60:1-63. doi: 10.1016/b978-0-12-407681-5.00001-5. PMID: 23724740

Recent systematic reviews

The Influence of Maternal Folate Status on Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Xu R, Liu S, Zhong Z, Guo Y, Xia T, Chen Y, Ding L
Nutrients 2023 Jun 16;15(12) doi: 10.3390/nu15122766. PMID: 37375669Free PMC Article
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics: A Systematic Review and Meta-Analysis.
Hoek J, Steegers-Theunissen RPM, Willemsen SP, Schoenmakers S
Mol Nutr Food Res 2020 May;64(9):e1900696. Epub 2020 Feb 20 doi: 10.1002/mnfr.201900696. PMID: 32032459Free PMC Article
Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
Low MS, Speedy J, Styles CE, De-Regil LM, Pasricha SR
Cochrane Database Syst Rev 2016 Apr 18;4(4):CD009747. doi: 10.1002/14651858.CD009747.pub2. PMID: 27087396Free PMC Article

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