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Locally Recurrent Merkel Cell Carcinoma

MedGen UID:
1711792
Concept ID:
C5237417
Neoplastic Process

Definition

The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Recurrent Merkel Cell Carcinoma

Professional guidelines

PubMed

Cornejo C, Miller CJ
Dermatol Clin 2019 Jul;37(3):269-277. Epub 2019 Apr 19 doi: 10.1016/j.det.2019.03.001. PMID: 31084721
Prewett SL, Ajithkumar T
Clin Oncol (R Coll Radiol) 2015 Aug;27(8):436-44. Epub 2015 May 23 doi: 10.1016/j.clon.2015.04.007. PMID: 26009549
Matkowski R, Lata E, Zietek M, Halon A, Forgacz J, Szynglarewicz B
J Dermatolog Treat 2014 Oct;25(5):409-14. Epub 2013 Aug 13 doi: 10.3109/09546634.2012.756969. PMID: 23216365

Recent clinical studies

Etiology

Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Nagase K, Narisawa Y
Curr Treat Options Oncol 2018 Sep 20;19(11):57. doi: 10.1007/s11864-018-0574-5. PMID: 30238195
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777
Verzì AE, Amin SM, Guitart J, Micali G
G Ital Dermatol Venereol 2015 Aug;150(4):419-28. PMID: 26224231

Diagnosis

Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Cornejo C, Miller CJ
Dermatol Clin 2019 Jul;37(3):269-277. Epub 2019 Apr 19 doi: 10.1016/j.det.2019.03.001. PMID: 31084721
Nagase K, Narisawa Y
Curr Treat Options Oncol 2018 Sep 20;19(11):57. doi: 10.1007/s11864-018-0574-5. PMID: 30238195
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777
Coggshall K, Tello TL, North JP, Yu SS
J Am Acad Dermatol 2018 Mar;78(3):433-442. Epub 2017 Dec 9 doi: 10.1016/j.jaad.2017.12.001. PMID: 29229574

Therapy

Kang C
Drugs 2023 Jun;83(8):731-737. doi: 10.1007/s40265-023-01884-7. PMID: 37184754
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG
Nat Commun 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3. PMID: 30250229Free PMC Article
Nagase K, Narisawa Y
Curr Treat Options Oncol 2018 Sep 20;19(11):57. doi: 10.1007/s11864-018-0574-5. PMID: 30238195
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777

Prognosis

Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Kwan K, Ghazizadeh S, Moon AS, Rünger D, Sajed D, Elashoff D, St John M
Otolaryngol Head Neck Surg 2020 Aug;163(2):364-371. Epub 2020 Mar 31 doi: 10.1177/0194599820913622. PMID: 32228136
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777
Verzì AE, Amin SM, Guitart J, Micali G
G Ital Dermatol Venereol 2015 Aug;150(4):419-28. PMID: 26224231

Clinical prediction guides

Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Coskun O, Sahin H, Yalcin S, Sahin YC, Coskun U
J Oncol Pharm Pract 2023 Sep;29(6):1510-1515. Epub 2023 May 30 doi: 10.1177/10781552231177712. PMID: 37254496
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Kwan K, Ghazizadeh S, Moon AS, Rünger D, Sajed D, Elashoff D, St John M
Otolaryngol Head Neck Surg 2020 Aug;163(2):364-371. Epub 2020 Mar 31 doi: 10.1177/0194599820913622. PMID: 32228136
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777

Recent systematic reviews

Truong K, Goldinger SM, Chou S, Howle JR, Veness MJ, Fernandez-Peñas P, Varey AHR
Australas J Dermatol 2022 Feb;63(1):e6-e12. Epub 2021 Dec 7 doi: 10.1111/ajd.13758. PMID: 34873684
Palencia R, Sandhu A, Webb S, Blaikie T, Bharmal M
Future Oncol 2021 Dec;17(34):4813-4822. Epub 2021 Sep 8 doi: 10.2217/fon-2021-0574. PMID: 34494443
Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, Pusceddu S
Radiother Oncol 2019 May;134:211-219. Epub 2019 Feb 28 doi: 10.1016/j.radonc.2019.02.015. PMID: 31005218
Gunaratne DA, Howle JR, Veness MJ
J Am Acad Dermatol 2017 Jul;77(1):142-148.e1. Epub 2017 May 9 doi: 10.1016/j.jaad.2017.02.015. PMID: 28495499
Raju S, Vazirnia A, Totri C, Hata TR
Dermatol Surg 2014 Dec;40(12):1273-83. doi: 10.1097/DSS.0000000000000131. PMID: 25350122

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