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Advanced Gastric Carcinoma

MedGen UID:
1719475
•Concept ID:
C4761226
•
Neoplastic Process

Definition

Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Differential diagnosis of malignant gastric tumors. A pathological appraisal with reference to locally advanced gastric carcinoma.
Canzonieri V, Bidoli E
Suppl Tumori 2003 Sep-Oct;2(5):S5-9. PMID: 12914380
Status of treatment for advanced gastric carcinoma.
Tsai JY, Safran H
Curr Oncol Rep 2003 May;5(3):210-8. doi: 10.1007/s11912-003-0112-9. PMID: 12667418
Brief review of advances in the treatment of gastric carcinoma in North America and Europe, 1995-2001.
Hasham-Jiwa N, Kasakura Y, Ajani JA
Int J Clin Oncol 2002 Aug;7(4):219-24. doi: 10.1007/s101470200033. PMID: 12202975

Recent clinical studies

Etiology

Two therapeutic regimens for advanced gastric carcinoma: DOS chemotherapy alone vs. trastuzumab combined with DOS.
Jiang N, Chen J, Jin Y
J BUON 2021 May-Jun;26(3):904-910. PMID: 34268952
The role of neoadjuvant FLOT chemotherapy with and without omega 3 in locally advanced gastric carcinoma.
Mohamed Abd Elaziz L, Salah T, Gharib F
J BUON 2020 Nov-Dec;25(6):2672-2677. PMID: 33455112
Feasibility research of treating advanced gastric carcinoma with laparoscopy.
Xi H, Li R, Yang H, Feng S, Qin R
J BUON 2017 Mar-Apr;22(2):725-729. PMID: 28730781
Epirubicin-based compared with docetaxel-based chemotherapy for advanced gastric carcinoma: A systematic review and meta-analysis.
Petrioli R, Roviello G, Zanotti L, Roviello F, Polom K, Bottini A, Marano L, Francini E, Marrelli D, Generali D
Crit Rev Oncol Hematol 2016 Jun;102:82-8. Epub 2016 Apr 8 doi: 10.1016/j.critrevonc.2016.04.001. PMID: 27083592
Radiotherapy for tumors of the stomach and gastroesophageal junction--a review of its role in multimodal therapy.
Buergy D, Lohr F, Baack T, Siebenlist K, Haneder S, Michaely H, Wenz F, Boda-Heggemann J
Radiat Oncol 2012 Nov 16;7:192. doi: 10.1186/1748-717X-7-192. PMID: 23157945Free PMC Article

Diagnosis

Synchronous Occurrence of Advanced Gastric Carcinoma with Retroperitoneal Liposarcoma: A Case Report.
Kobayashi H, Ohashi R, Ujita M, Ueki K, Seki R, Fukuda S, Rubin B
Am J Case Rep 2022 Jan 8;23:e934586. doi: 10.12659/AJCR.934586. PMID: 34996885Free PMC Article
Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma.
Xue LJ, Mao XB, Ren LL, Chu XY
Cancer Med 2017 Jun;6(6):1424-1436. Epub 2017 May 23 doi: 10.1002/cam4.1085. PMID: 28544785Free PMC Article
Targeted therapy in advanced gastric carcinoma: the future is beginning.
Schinzari G, Cassano A, Orlandi A, Basso M, Barone C
Curr Med Chem 2014;21(8):1026-38. doi: 10.2174/0929867321666131129124054. PMID: 24304282
Differential diagnosis of malignant gastric tumors. A pathological appraisal with reference to locally advanced gastric carcinoma.
Canzonieri V, Bidoli E
Suppl Tumori 2003 Sep-Oct;2(5):S5-9. PMID: 12914380
Chemotherapy for gastric carcinoma: new and old options.
Ajani JA
Oncology (Williston Park) 1998 Oct;12(10 Suppl 7):44-7. PMID: 9830625

Therapy

Two therapeutic regimens for advanced gastric carcinoma: DOS chemotherapy alone vs. trastuzumab combined with DOS.
Jiang N, Chen J, Jin Y
J BUON 2021 May-Jun;26(3):904-910. PMID: 34268952
Histopathological factors predicting response to neoadjuvant therapy in gastric carcinoma.
Sánchez de Molina ML, Díaz Del Arco C, Vorwald P, García-Olmo D, Estrada L, Fernández-Aceñero MJ
Clin Transl Oncol 2018 Feb;20(2):253-257. Epub 2017 Jun 26 doi: 10.1007/s12094-017-1707-1. PMID: 28653276
Targeted therapy in advanced gastric carcinoma: the future is beginning.
Schinzari G, Cassano A, Orlandi A, Basso M, Barone C
Curr Med Chem 2014;21(8):1026-38. doi: 10.2174/0929867321666131129124054. PMID: 24304282
Chemotherapy for gastric carcinoma: new and old options.
Ajani JA
Oncology (Williston Park) 1998 Oct;12(10 Suppl 7):44-7. PMID: 9830625
Current status of therapy for advanced gastric carcinoma.
Ajani JA
Oncology (Williston Park) 1998 Aug;12(8 Suppl 6):99-102. PMID: 9726100

Prognosis

Comparison of laparoscopic surgery with open standard surgery for advanced gastric carcinoma in a single institute: a propensity score matching analysis.
Yamamoto M, Shimokawa M, Ohta M, Uehara H, Sugiyama M, Nakashima Y, Nakanoko T, Ikebe M, Shin Y, Shiokawa K, Morita M, Toh Y
Surg Endosc 2022 May;36(5):3356-3364. Epub 2021 Aug 23 doi: 10.1007/s00464-021-08652-2. PMID: 34426875
Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling.
Fu D, Wang C, Yu L, Yu R
Cell Mol Biol Lett 2021 Jun 7;26(1):26. doi: 10.1186/s11658-021-00271-y. PMID: 34098867Free PMC Article
Proximal Gastric Resection with Posterior Esophago-Gastrostomy and Partial Neo-Fundoplication in the Treatment of Advanced Upper Gastric Carcinoma.
Polkowski WP, Mielko J, Gęca K, Rawicz-Pruszyński K, Ciseł B, Kurylcio A, Skórzewska M
Dig Surg 2020;37(2):119-128. Epub 2019 Mar 25 doi: 10.1159/000497452. PMID: 30909273
Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer.
Koizumi K, Kato S, Sakurai H, Hashimoto I, Yasumoto K, Saiki I
Front Biosci (Schol Ed) 2012 Jan 1;4(1):269-76. doi: 10.2741/s267. PMID: 22202059
(Neo)adjuvant strategies of advanced gastric carcinoma: time for a change?
Moehler M, Schimanski CC, Gockel I, Junginger T, Galle PR
Dig Dis 2004;22(4):345-50. doi: 10.1159/000083597. PMID: 15812158

Clinical prediction guides

Comparison of laparoscopic surgery with open standard surgery for advanced gastric carcinoma in a single institute: a propensity score matching analysis.
Yamamoto M, Shimokawa M, Ohta M, Uehara H, Sugiyama M, Nakashima Y, Nakanoko T, Ikebe M, Shin Y, Shiokawa K, Morita M, Toh Y
Surg Endosc 2022 May;36(5):3356-3364. Epub 2021 Aug 23 doi: 10.1007/s00464-021-08652-2. PMID: 34426875
Two therapeutic regimens for advanced gastric carcinoma: DOS chemotherapy alone vs. trastuzumab combined with DOS.
Jiang N, Chen J, Jin Y
J BUON 2021 May-Jun;26(3):904-910. PMID: 34268952
Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling.
Fu D, Wang C, Yu L, Yu R
Cell Mol Biol Lett 2021 Jun 7;26(1):26. doi: 10.1186/s11658-021-00271-y. PMID: 34098867Free PMC Article
Comparison of PD-L1 immunohistochemical assays in advanced gastric adenocarcinomas using endoscopic biopsy and paired resected specimens.
Kim SW, Jeong G, Ryu MH, Park YS
Pathology 2021 Aug;53(5):586-594. Epub 2021 Feb 3 doi: 10.1016/j.pathol.2020.10.015. PMID: 33546812
The role of neoadjuvant FLOT chemotherapy with and without omega 3 in locally advanced gastric carcinoma.
Mohamed Abd Elaziz L, Salah T, Gharib F
J BUON 2020 Nov-Dec;25(6):2672-2677. PMID: 33455112

Recent systematic reviews

Epirubicin-based compared with docetaxel-based chemotherapy for advanced gastric carcinoma: A systematic review and meta-analysis.
Petrioli R, Roviello G, Zanotti L, Roviello F, Polom K, Bottini A, Marano L, Francini E, Marrelli D, Generali D
Crit Rev Oncol Hematol 2016 Jun;102:82-8. Epub 2016 Apr 8 doi: 10.1016/j.critrevonc.2016.04.001. PMID: 27083592

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