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Abnormal circulating short-chain fatty-acid concentration

MedGen UID:
1723401
•Concept ID:
C5421641
•
Finding
HPO: HP:0033147

Definition

Any deviation from the normal concentration of a short-chain fatty acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating short-chain fatty-acid concentration

Professional guidelines

PubMed

Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729

Recent clinical studies

Etiology

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
The relationship between valproate induced tremors and circulating neurotransmitters: a preliminary study.
Hamed SA, Abdellah MM
Int J Neurosci 2017 Mar;127(3):236-242. Epub 2016 May 9 doi: 10.1080/00207454.2016.1181631. PMID: 27161592
Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis.
Zighetti ML, Fontana G, Lussana F, Chiesa V, Vignoli A, Canevini MP, Cattaneo M
Epilepsia 2015 May;56(5):e49-52. Epub 2015 Mar 11 doi: 10.1111/epi.12952. PMID: 25757394
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729
Plasma immunoreactive somatostatin is elevated in diabetic ketoacidosis and correlates with plasma non-esterified fatty acid concentration.
Binimelis J, Webb SM, Serrano J, Codina M, Corcoy R, Perez A, Peinado MA, Puig M, de la Torre W, Serrat J
Diabet Med 1987 May-Jun;4(3):221-4. doi: 10.1111/j.1464-5491.1987.tb00866.x. PMID: 2886248

Diagnosis

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991

Therapy

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
The relationship between valproate induced tremors and circulating neurotransmitters: a preliminary study.
Hamed SA, Abdellah MM
Int J Neurosci 2017 Mar;127(3):236-242. Epub 2016 May 9 doi: 10.1080/00207454.2016.1181631. PMID: 27161592
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729
Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol.
Syvänne M, Nieminen MS, Frick MH, Kauma H, Majahalme S, Virtanen V, Kesäniemi YA, Pasternack A, Ehnholm C, Taskinen MR
Circulation 1998 Nov 10;98(19):1993-9. doi: 10.1161/01.cir.98.19.1993. PMID: 9808595
Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group.
Frick MH, Syvänne M, Nieminen MS, Kauma H, Majahalme S, Virtanen V, Kesäniemi YA, Pasternack A, Taskinen MR
Circulation 1997 Oct 7;96(7):2137-43. doi: 10.1161/01.cir.96.7.2137. PMID: 9337181

Prognosis

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol.
Syvänne M, Nieminen MS, Frick MH, Kauma H, Majahalme S, Virtanen V, Kesäniemi YA, Pasternack A, Ehnholm C, Taskinen MR
Circulation 1998 Nov 10;98(19):1993-9. doi: 10.1161/01.cir.98.19.1993. PMID: 9808595
Cerebral blood flow and cerebral metabolism in children following cardiac surgery with deep hypothermia and circulatory arrest. Clinical course and follow-up of psychomotor development.
Settergren G, Ohqvist G, Lundberg S, Henze A, Björk VO, Persson B
Scand J Thorac Cardiovasc Surg 1982;16(3):209-15. doi: 10.3109/14017438209101051. PMID: 6820574

Clinical prediction guides

Biochemical variants of Smith-Lemli-Opitz syndrome.
Neklason DW, Andrews KM, Kelley RI, Metherall JE
Am J Med Genet 1999 Aug 27;85(5):517-23. doi: 10.1002/(sici)1096-8628(19990827)85:5<517::aid-ajmg18>3.0.co;2-1. PMID: 10405455
Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol.
Syvänne M, Nieminen MS, Frick MH, Kauma H, Majahalme S, Virtanen V, Kesäniemi YA, Pasternack A, Ehnholm C, Taskinen MR
Circulation 1998 Nov 10;98(19):1993-9. doi: 10.1161/01.cir.98.19.1993. PMID: 9808595

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