U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Skin Atypical Lipomatous Tumor/Well Differentiated Liposarcoma

MedGen UID:
1753798
•Concept ID:
C5418575
•
Neoplastic Process
Synonyms: Skin ALT/WDLPS; Skin Atypical Lipomatous Tumor; Skin Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma

Definition

A rare atypical lipomatous tumor/well differentiated liposarcoma arising from the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Atypical Lipomatous Tumor/Well Differentiated Liposarcoma

Professional guidelines

PubMed

Local Recurrence Rates of Skin Tumors After Resection With Complete Circumferential Peripheral and Deep Margin Assessment-Identification of High-Risk Entities.
Kofler L, Breuninger H, Schulz C, Häfner HM, Kofler K
Dermatol Surg 2021 Feb 1;47(2):e31-e36. doi: 10.1097/DSS.0000000000002431. PMID: 33565775
Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.
Tardío JC, Pinedo F, Aramburu JA, Martínez-González MÁ, Arias D, Khedaoui R, Suárez-Massa D, Santonja C
Am J Dermatopathol 2016 Aug;38(8):586-92. doi: 10.1097/DAD.0000000000000465. PMID: 26848640
Primary and metastatic malignant tumors in soft tissue of skin. Diagnostic, surgical, and prognostic considerations for the foot.
Potter GK, Ward KA
Clin Podiatr Med Surg 1996 Jan;13(1):155-72. PMID: 8849939

Recent clinical studies

Etiology

Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Sargen MR, Kim J, Potjer TP, Velthuizen ME, Martir-Negron AE, Odia Y, Helgadottir H, Hatton JN, Haley JS, Thone G, Widemann BC, Gross AM, Yohe ME, Kaplan RN, Shern JF, Sundby RT, Astiazaran-Symonds E, Yang XR, Carey DJ, Tucker MA, Stewart DR, Goldstein AM
JAMA Dermatol 2023 Oct 1;159(10):1112-1118. doi: 10.1001/jamadermatol.2023.2621. PMID: 37585199Free PMC Article
Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Cutaneous sarcomas.
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-648. doi: 10.1111/ddg.13249. PMID: 28591457
Kutane Sarkome.
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-649. doi: 10.1111/ddg.13249_g. PMID: 28591446
Congenital melanocytic naevi.
Kovalyshyn I, Braun R, Marghoob A
Australas J Dermatol 2009 Nov;50(4):231-40; quiz 241-2. doi: 10.1111/j.1440-0960.2009.00553_1.x. PMID: 19916964

Diagnosis

Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Sargen MR, Kim J, Potjer TP, Velthuizen ME, Martir-Negron AE, Odia Y, Helgadottir H, Hatton JN, Haley JS, Thone G, Widemann BC, Gross AM, Yohe ME, Kaplan RN, Shern JF, Sundby RT, Astiazaran-Symonds E, Yang XR, Carey DJ, Tucker MA, Stewart DR, Goldstein AM
JAMA Dermatol 2023 Oct 1;159(10):1112-1118. doi: 10.1001/jamadermatol.2023.2621. PMID: 37585199Free PMC Article
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Cutaneous sarcomas.
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-648. doi: 10.1111/ddg.13249. PMID: 28591457
Kutane Sarkome.
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-649. doi: 10.1111/ddg.13249_g. PMID: 28591446

Therapy

Pathologic Complete Response and Clinical Outcomes in Patients With Localized Soft Tissue Sarcoma Treated With Neoadjuvant Chemoradiotherapy or Radiotherapy: The NRG/RTOG 9514 and 0630 Nonrandomized Clinical Trials.
Wang D, Harris J, Kraybill WG, Eisenberg B, Kirsch DG, Ettinger DS, Kane JM 3rd, Barry PN, Naghavi A, Freeman CR, Chen YL, Hitchcock YJ, Bedi M, Salerno KE, Severin D, Godette KD, Larrier NA, Curran WJ Jr, Torres-Saavedra PA, Lucas DR
JAMA Oncol 2023 May 1;9(5):646-655. doi: 10.1001/jamaoncol.2023.0042. PMID: 36995690Free PMC Article
Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature.
Chambers M, Badin DJ, Sriharan AA, Linos KD
J Cutan Pathol 2020 Jun;47(6):554-560. Epub 2020 Feb 11 doi: 10.1111/cup.13650. PMID: 31995237
Successful treatment of advanced pancreatic liposarcoma with apatinib: A case report and literature review.
Han T, Luan Y, Xu Y, Yang X, Li J, Liu R, Li Q, Zheng Z
Cancer Biol Ther 2017 Sep 2;18(9):635-639. Epub 2017 Jul 5 doi: 10.1080/15384047.2017.1345394. PMID: 28678611Free PMC Article
Skin conditions: benign nodular skin lesions.
Nguyen T, Zuniga R
FP Essent 2013 Apr;407:24-30. PMID: 23600336
Hyperthermia in cancer treatment: current and future prospects.
U R, Noell KT, Worde BT, Woodward KT, Fishburn RI, Miller LS, Herskovic AM
Gan To Kagaku Ryoho 1982 Mar;9(3):343-56. PMID: 6764104

Prognosis

Superficial dedifferentiated liposarcoma: A clinicopathologic study.
Bourgeau M, Gandhi JS, Deeb KK, Bahrami A
Hum Pathol 2024 Mar;145:63-70. Epub 2024 Feb 27 doi: 10.1016/j.humpath.2024.02.008. PMID: 38423223
Primary parotid liposarcoma.
Košec A, Zurak K, Čupić H, Bedeković V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Oct;136(5):405-408. Epub 2019 Mar 12 doi: 10.1016/j.anorl.2018.01.013. PMID: 30876853
Cutaneous sarcomas.
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-648. doi: 10.1111/ddg.13249. PMID: 28591457
Kutane Sarkome.
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-649. doi: 10.1111/ddg.13249_g. PMID: 28591446
Cutaneous lipomatous neoplasms.
Mentzel T
Semin Diagn Pathol 2001 Nov;18(4):250-7. PMID: 11757864

Clinical prediction guides

Pancreatic liposarcoma: a case report.
Tanabe M, Matsui H, Higashi M, Tokumitsu Y, Nagano H, Ito K
Abdom Radiol (NY) 2022 Jun;47(6):1912-1916. Epub 2022 May 4 doi: 10.1007/s00261-022-03522-4. PMID: 35507066
Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.
Tardío JC, Pinedo F, Aramburu JA, Martínez-González MÁ, Arias D, Khedaoui R, Suárez-Massa D, Santonja C
Am J Dermatopathol 2016 Aug;38(8):586-92. doi: 10.1097/DAD.0000000000000465. PMID: 26848640
Liposarcoma: new entities and evolving concepts.
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304
Spindle-cell lipoma of the skin.
Duve S, Müller-Höcker J, Worret WI
Am J Dermatopathol 1995 Oct;17(5):529-33. doi: 10.1097/00000372-199510000-00017. PMID: 8599462

Recent systematic reviews

Immune checkpoint inhibitors in treatment of soft-tissue sarcoma: A systematic review and meta-analysis.
Saerens M, Brusselaers N, Rottey S, Decruyenaere A, Creytens D, Lapeire L
Eur J Cancer 2021 Jul;152:165-182. Epub 2021 Jun 6 doi: 10.1016/j.ejca.2021.04.034. PMID: 34107450

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...