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Increased non-HDL cholesterol concentration

MedGen UID:
1781215
•Concept ID:
C5539728
•
Finding
Synonym: Elevated non-HDL cholesterol concentration
 
HPO: HP:0033626

Definition

Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased non-HDL cholesterol concentration

Professional guidelines

PubMed

Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis.
Sheridan DA, Shawa IT, Thomas EL, Felmlee DJ, Bridge SH, Neely D, Cobbold JF, Holmes E, Bassendine MF, Taylor-Robinson SD
Sci Rep 2022 Apr 1;12(1):5562. doi: 10.1038/s41598-022-09588-w. PMID: 35365728Free PMC Article
Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression.
Bekhbat M, Chu K, Le NA, Woolwine BJ, Haroon E, Miller AH, Felger JC
Psychoneuroendocrinology 2018 Dec;98:222-229. Epub 2018 Sep 6 doi: 10.1016/j.psyneuen.2018.09.004. PMID: 30249443Free PMC Article
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Recent clinical studies

Etiology

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Inflammation and atherosclerosis.
Poledne R, Lesná IK
Vnitr Lek 2019 Winter;64(12):1142-1146. PMID: 30704248
Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.
Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG
BMJ Open 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019Free PMC Article

Diagnosis

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
Quantifying the contribution of lipoprotein(a) to all apoB containing particles.
Chilazi M, Zheng W, Park J, Marvel FA, Khoury S, Jones SR, Martin SS
J Clin Lipidol 2022 Mar-Apr;16(2):220-226. Epub 2022 Feb 12 doi: 10.1016/j.jacl.2022.02.004. PMID: 35241398
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Inflammation and atherosclerosis.
Poledne R, Lesná IK
Vnitr Lek 2019 Winter;64(12):1142-1146. PMID: 30704248
Fasting and nonfasting triglycerides in cardiovascular and other diseases.
Piťha J, Kovář J, Blahová T
Physiol Res 2015;64(Suppl 3):S323-30. doi: 10.33549/physiolres.933196. PMID: 26680665

Therapy

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S
J Clin Endocrinol Metab 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. PMID: 36740954
The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.
Xu D, Feng M, Chu Y, Wang S, Shete V, Tuohy KM, Liu F, Zhou X, Kamil A, Pan D, Liu H, Yang X, Yang C, Zhu B, Lv N, Xiong Q, Wang X, Sun J, Sun G, Yang Y
Front Immunol 2021;12:787797. Epub 2021 Dec 9 doi: 10.3389/fimmu.2021.787797. PMID: 34956218Free PMC Article
Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.
Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG
BMJ Open 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. PMID: 29511019Free PMC Article
Fibrates and niacin: is there a place for them in clinical practice?
Wierzbicki AS, Viljoen A
Expert Opin Pharmacother 2014 Dec;15(18):2673-80. Epub 2014 Oct 16 doi: 10.1517/14656566.2014.972365. PMID: 25318657
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Prognosis

Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study.
Ding X, Zhou H, Yue Q, Shu Z, Ma X, Li Y, Wu S
BMJ Open 2023 Apr 25;13(4):e069807. doi: 10.1136/bmjopen-2022-069807. PMID: 37185179Free PMC Article
Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis.
Mardi P, Abdi F, Ehsani A, Seif E, Djalalinia S, Heshmati J, Shahrestanaki E, Gorabi AM, Qorbani M
Front Endocrinol (Lausanne) 2022;13:957136. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.957136. PMID: 36176470Free PMC Article
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH
Nat Med 2022 Aug;28(8):1672-1678. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01936-7. PMID: 35953719
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
Cardiovascular disease and dyslipidemia: beyond LDL.
Pöss J, Custodis F, Werner C, Weingärtner O, Böhm M, Laufs U
Curr Pharm Des 2011;17(9):861-70. doi: 10.2174/138161211795428858. PMID: 21418031

Clinical prediction guides

Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study.
Ding X, Zhou H, Yue Q, Shu Z, Ma X, Li Y, Wu S
BMJ Open 2023 Apr 25;13(4):e069807. doi: 10.1136/bmjopen-2022-069807. PMID: 37185179Free PMC Article
Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis.
Mardi P, Abdi F, Ehsani A, Seif E, Djalalinia S, Heshmati J, Shahrestanaki E, Gorabi AM, Qorbani M
Front Endocrinol (Lausanne) 2022;13:957136. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.957136. PMID: 36176470Free PMC Article
Efficacy and Safety of K-877 (Pemafibrate), a Selective PPARα Modulator, in European Patients on Statin Therapy.
Ginsberg HN, Hounslow NJ, Senko Y, Suganami H, Bogdanski P, Ceska R, Kalina A, Libis RA, Supryadkina TV, Hovingh GK
Diabetes Care 2022 Apr 1;45(4):898-908. doi: 10.2337/dc21-1288. PMID: 35238894
New targets for treating hypertriglyceridemia.
Parhofer KG
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):106-111. doi: 10.1097/MED.0000000000000714. PMID: 35045528
Cardiovascular disease and dyslipidemia: beyond LDL.
Pöss J, Custodis F, Werner C, Weingärtner O, Böhm M, Laufs U
Curr Pharm Des 2011;17(9):861-70. doi: 10.2174/138161211795428858. PMID: 21418031

Recent systematic reviews

Avocado Consumption and Cardiometabolic Health: A Systematic Review and Meta-Analysis.
James-Martin G, Brooker PG, Hendrie GA, Stonehouse W
J Acad Nutr Diet 2024 Feb;124(2):233-248.e4. Epub 2022 Dec 21 doi: 10.1016/j.jand.2022.12.008. PMID: 36565850
Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis.
Mardi P, Abdi F, Ehsani A, Seif E, Djalalinia S, Heshmati J, Shahrestanaki E, Gorabi AM, Qorbani M
Front Endocrinol (Lausanne) 2022;13:957136. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.957136. PMID: 36176470Free PMC Article
Effect of Hydroxychloroquine on Lipid Levels: A Systematic Review and Metaanalysis.
Simental-Mendía LE, Simental-Mendía M, Sánchez-García A, Linden-Torres E
Curr Pharm Des 2021;27(40):4133-4139. doi: 10.2174/1381612827666210625162612. PMID: 34176459
Serum lipid concentrations among persons with spinal cord injury - a systematic review and meta-analysis of the literature.
Gilbert O, Croffoot JR, Taylor AJ, Nash M, Schomer K, Groah S
Atherosclerosis 2014 Feb;232(2):305-12. Epub 2013 Nov 18 doi: 10.1016/j.atherosclerosis.2013.11.028. PMID: 24468143

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