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Male Reproductive System Carcinoma

MedGen UID:
1793338
•Concept ID:
C5556897
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMale Reproductive System Carcinoma

Professional guidelines

PubMed

The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature.
Kravvas G, Ge L, Ng J, Shim TN, Doiron PR, Watchorn R, Kentley J, Panou E, Dinneen M, Freeman A, Jameson C, Haider A, Francis N, Minhas S, Alnajjar H, Muneer A, Bunker CB
J Dermatolog Treat 2022 Mar;33(2):1047-1062. Epub 2020 Aug 6 doi: 10.1080/09546634.2020.1800574. PMID: 32705920
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Transcriptomic Features of Cribriform and Intraductal Carcinoma of the Prostate.
Lone Z, Benidir T, Rainey M, Nair M, Davicioni E, Gibb EA, Williamson S, Gupta S, Chaim Ornstein M, Tendulkar R, Weight C, Nguyen JK, Klein EA, Mian OY
Eur Urol Focus 2022 Nov;8(6):1575-1582. Epub 2022 May 31 doi: 10.1016/j.euf.2022.05.005. PMID: 35662504
Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article

Diagnosis

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Penoscrotal Paget's disease.
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
Urologic Dermatology: a Review.
Stamm AW, Kobashi KC, Stefanovic KB
Curr Urol Rep 2017 Aug;18(8):62. doi: 10.1007/s11934-017-0712-9. PMID: 28667573
Scrotal tumors.
Armas-Alvarez AL, Salinas-Sánchez AS, Atienzar-Tobarra M, Virseda-Rodríguez JA
Arch Esp Urol 2016 Mar;69(2):86-9. PMID: 26959967

Therapy

Penile self-amputation.
Mumoli N, Giorgi-Pierfranceschi M, Porta C, Manzionna G, Barberio M
Intern Emerg Med 2018 Oct;13(7):1133. Epub 2018 Jun 26 doi: 10.1007/s11739-018-1899-6. PMID: 29943166
Premalignancy in Prostate Cancer: Rethinking What we Know.
De Marzo AM, Haffner MC, Lotan TL, Yegnasubramanian S, Nelson WG
Cancer Prev Res (Phila) 2016 Aug;9(8):648-56. Epub 2016 Jan 26 doi: 10.1158/1940-6207.CAPR-15-0431. PMID: 26813971
Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation.
Lipianskaya J, Cohen A, Chen CJ, Hsia E, Squires J, Li Z, Zhang Y, Li W, Chen X, Xu H, Huang J
Asian J Androl 2014 Jul-Aug;16(4):541-4. doi: 10.4103/1008-682X.123669. PMID: 24589459Free PMC Article
Diagnosis of prostatic carcinoma after therapy.
Bostwick DG, Meiers I
Arch Pathol Lab Med 2007 Mar;131(3):360-71. doi: 10.5858/2007-131-360-DOPCAT. PMID: 17516739
The dysfunctional foreskin.
Porter WM, Bunker CB
Int J STD AIDS 2001 Apr;12(4):216-20. doi: 10.1258/0956462011922922. PMID: 11319970

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Clinical prediction guides

Clinical Profile and Predictors of Survival in Carcinoma Penis Patients.
Garg V, Ray M, Haresh KP, Sahoo RK, Sharma A, Kaushal S, Batra A
Curr Oncol 2023 Apr 28;30(5):4563-4574. doi: 10.3390/curroncol30050345. PMID: 37232803Free PMC Article
Clear cell carcinoma of testis: A review.
Lin M, Awalt H, Ayala AG, Ro JY
Ann Diagn Pathol 2019 Jun;40:26-29. Epub 2019 Mar 20 doi: 10.1016/j.anndiagpath.2019.03.002. PMID: 30921621
Intraductal carcinoma of the prostate: What we know and what we do not know.
Chen X, Ding B, Zhang P, Geng S, Xu J, Han B
Pathol Res Pract 2018 May;214(5):612-618. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.003. PMID: 29628124
Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline.
van Casteren NJ, Looijenga LH, Dohle GR
Int J Androl 2009 Aug;32(4):279-87. Epub 2008 Dec 22 doi: 10.1111/j.1365-2605.2008.00937.x. PMID: 19207616

Recent systematic reviews

Urothelial Carcinoma and Prostate-specific Membrane Antigen: Cellular, Imaging, and Prognostic Implications.
Tariq A, McCart Reed AE, Morton A, Porten S, Vela I, Williams ED, Yaxley JW, Black PC, Roberts MJ
Eur Urol Focus 2022 Sep;8(5):1256-1269. Epub 2021 Aug 21 doi: 10.1016/j.euf.2021.07.016. PMID: 34429271
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956
Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review.
Siepe G, Buwenge M, Nguyen NP, Macchia G, Deodato F, Cilla S, Mattiucci GC, Capocaccia I, Cammelli S, Guido A, Arcelli A, Ntreta M, Guerri S, Morganti AG
Anticancer Res 2018 Mar;38(3):1221-1230. doi: 10.21873/anticanres.12343. PMID: 29491044
Urologic complications of genitourinary schistosomiasis.
Khalaf I, Shokeir A, Shalaby M
World J Urol 2012 Feb;30(1):31-8. Epub 2011 Sep 10 doi: 10.1007/s00345-011-0751-7. PMID: 21909645

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