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Reduced circulating creatine concentration

MedGen UID:
1815054
•Concept ID:
C5706148
•
Finding
HPO: HP:0034292

Definition

An reduction below the normal range of creatine in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating creatine concentration

Professional guidelines

PubMed

Prophylaxis and treatment of foetal growth restriction.
Nawathe A, David AL
Best Pract Res Clin Obstet Gynaecol 2018 May;49:66-78. Epub 2018 Feb 23 doi: 10.1016/j.bpobgyn.2018.02.007. PMID: 29656983

Recent clinical studies

Etiology

Creatine supplementation does not promote additional effects on inflammation and insulin resistance in older adults: A pilot randomized, double-blind, placebo-controlled trial.
Oliveira CLP, Antunes BMM, Gomes AC, Lira FS, Pimentel GD, Boulé NG, Mota JF
Clin Nutr ESPEN 2020 Aug;38:94-98. Epub 2020 Jun 23 doi: 10.1016/j.clnesp.2020.05.024. PMID: 32690185
Prophylaxis and treatment of foetal growth restriction.
Nawathe A, David AL
Best Pract Res Clin Obstet Gynaecol 2018 May;49:66-78. Epub 2018 Feb 23 doi: 10.1016/j.bpobgyn.2018.02.007. PMID: 29656983
Cardiac protection with phosphocreatine: a meta-analysis.
Landoni G, Zangrillo A, Lomivorotov VV, Likhvantsev V, Ma J, De Simone F, Fominskiy E
Interact Cardiovasc Thorac Surg 2016 Oct;23(4):637-46. Epub 2016 Jun 17 doi: 10.1093/icvts/ivw171. PMID: 27318357
The effect of L-arginine and creatine on vascular function and homocysteine metabolism.
Jahangir E, Vita JA, Handy D, Holbrook M, Palmisano J, Beal R, Loscalzo J, Eberhardt RT
Vasc Med 2009 Aug;14(3):239-48. doi: 10.1177/1358863X08100834. PMID: 19651674Free PMC Article
The safety of statins in clinical practice.
Armitage J
Lancet 2007 Nov 24;370(9601):1781-90. doi: 10.1016/S0140-6736(07)60716-8. PMID: 17559928

Diagnosis

Determination of Intrinsic Creatine Transporter (Slc6a8) Activity and Creatine Transport Function of Leukocytes in Rats.
Taii A, Tachikawa M, Ohta Y, Hosoya KI, Terasaki T
Biol Pharm Bull 2020;43(3):474-479. doi: 10.1248/bpb.b19-00807. PMID: 32115505
Prophylaxis and treatment of foetal growth restriction.
Nawathe A, David AL
Best Pract Res Clin Obstet Gynaecol 2018 May;49:66-78. Epub 2018 Feb 23 doi: 10.1016/j.bpobgyn.2018.02.007. PMID: 29656983
¹H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus.
Ouyang X, Dai Y, Wen JL, Wang LX
Lupus 2011 Nov;20(13):1411-20. Epub 2011 Oct 5 doi: 10.1177/0961203311418707. PMID: 21976403
Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction.
Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, Calieri J, Hoffmeyer D, Syed T, Ghanim H, Aljada A, Dandona P
Circulation 2004 Feb 24;109(7):849-54. Epub 2004 Feb 2 doi: 10.1161/01.CIR.0000116762.77804.FC. PMID: 14757687
Imaging and epilepsy.
Duncan JS
Brain 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. PMID: 9117380

Therapy

Creatine supplementation does not promote additional effects on inflammation and insulin resistance in older adults: A pilot randomized, double-blind, placebo-controlled trial.
Oliveira CLP, Antunes BMM, Gomes AC, Lira FS, Pimentel GD, Boulé NG, Mota JF
Clin Nutr ESPEN 2020 Aug;38:94-98. Epub 2020 Jun 23 doi: 10.1016/j.clnesp.2020.05.024. PMID: 32690185
Prophylaxis and treatment of foetal growth restriction.
Nawathe A, David AL
Best Pract Res Clin Obstet Gynaecol 2018 May;49:66-78. Epub 2018 Feb 23 doi: 10.1016/j.bpobgyn.2018.02.007. PMID: 29656983
Cardiac protection with phosphocreatine: a meta-analysis.
Landoni G, Zangrillo A, Lomivorotov VV, Likhvantsev V, Ma J, De Simone F, Fominskiy E
Interact Cardiovasc Thorac Surg 2016 Oct;23(4):637-46. Epub 2016 Jun 17 doi: 10.1093/icvts/ivw171. PMID: 27318357
The effect of L-arginine and creatine on vascular function and homocysteine metabolism.
Jahangir E, Vita JA, Handy D, Holbrook M, Palmisano J, Beal R, Loscalzo J, Eberhardt RT
Vasc Med 2009 Aug;14(3):239-48. doi: 10.1177/1358863X08100834. PMID: 19651674Free PMC Article
The safety of statins in clinical practice.
Armitage J
Lancet 2007 Nov 24;370(9601):1781-90. doi: 10.1016/S0140-6736(07)60716-8. PMID: 17559928

Prognosis

A comprehensive analysis of metabolic changes in the salvaged penumbra.
Bivard A, Yassi N, Krishnamurthy V, Lin L, Levi C, Spratt NJ, Mittef F, Davis S, Parsons M
Neuroradiology 2016 Apr;58(4):409-15. Epub 2016 Jan 6 doi: 10.1007/s00234-015-1638-x. PMID: 26738878
Anti-Inflammatory Treatment With Colchicine in Acute Myocardial Infarction: A Pilot Study.
Deftereos S, Giannopoulos G, Angelidis C, Alexopoulos N, Filippatos G, Papoutsidakis N, Sianos G, Goudevenos J, Alexopoulos D, Pyrgakis V, Cleman MW, Manolis AS, Tousoulis D, Lekakis J
Circulation 2015 Oct 13;132(15):1395-403. Epub 2015 Aug 11 doi: 10.1161/CIRCULATIONAHA.115.017611. PMID: 26265659
Myoglobin clearance by continuous venous-venous haemofiltration in rhabdomyolysis with acute kidney injury: a case series.
Zhang L, Kang Y, Fu P, Cao Y, Shi Y, Liu F, Hu Z, Su B, Tang W, Qin W
Injury 2012 May;43(5):619-23. Epub 2010 Sep 16 doi: 10.1016/j.injury.2010.08.031. PMID: 20843513
¹H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus.
Ouyang X, Dai Y, Wen JL, Wang LX
Lupus 2011 Nov;20(13):1411-20. Epub 2011 Oct 5 doi: 10.1177/0961203311418707. PMID: 21976403
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350

Clinical prediction guides

Downregulation of DLGAP1-Antisense RNA 1 Alleviates Vascular Endothelial Cell Injury Via Activation of the Phosphoinositide 3-kinase/Akt Pathway Results from an Acute Limb Ischemia Rat Model.
Shen GH, Song Y, Yao Y, Sun QF, Jing B, Wu J, Li SY, Liu SQ, Li HC, Yuan C, Liu GY, Li JB, Liu XY, Wang HY
Eur J Vasc Endovasc Surg 2020 Jan;59(1):98-107. Epub 2019 Nov 16 doi: 10.1016/j.ejvs.2019.06.032. PMID: 31744785
A comprehensive analysis of metabolic changes in the salvaged penumbra.
Bivard A, Yassi N, Krishnamurthy V, Lin L, Levi C, Spratt NJ, Mittef F, Davis S, Parsons M
Neuroradiology 2016 Apr;58(4):409-15. Epub 2016 Jan 6 doi: 10.1007/s00234-015-1638-x. PMID: 26738878
Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage.
Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T
Circ Cardiovasc Genet 2011 Aug 1;4(4):446-54. Epub 2011 Jun 2 doi: 10.1161/CIRCGENETICS.110.958975. PMID: 21642241
Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study.
Bottomley PA, Wu KC, Gerstenblith G, Schulman SP, Steinberg A, Weiss RG
Circulation 2009 Apr 14;119(14):1918-24. Epub 2009 Mar 30 doi: 10.1161/CIRCULATIONAHA.108.823187. PMID: 19332463Free PMC Article
Elevated muscle glycogen and anaerobic energy production during exhaustive exercise in man.
Bangsbo J, Graham TE, Kiens B, Saltin B
J Physiol 1992;451:205-27. doi: 10.1113/jphysiol.1992.sp019161. PMID: 1403811Free PMC Article

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