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Elevated circulating biliverdin concentration

MedGen UID:
1815106
Concept ID:
C5706200
Finding
HPO: HP:0034383

Definition

Increased concentration of biliverdin, a green tetrapyrrolic bile pigment, in the blood circulation. [from HPO]

Term Hierarchy

Conditions with this feature

Hyperbiliverdinemia
MedGen UID:
481594
Concept ID:
C3279964
Disease or Syndrome
Hyperbiliverdinemia can manifest as green jaundice, which is a green discoloration of the skin, urine, serum, and other bodily fluids, due to increased biliverdin resulting from inefficient conversion to bilirubin. Although rarely reported, affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. Green jaundice has also been associated with malnutrition, medication, and congenital biliary atresia (summary by Huffman et al., 2009).

Recent clinical studies

Clinical prediction guides

Bulmer AC, Ried K, Blanchfield JT, Wagner KH
Mutat Res 2008 Jan-Feb;658(1-2):28-41. Epub 2007 May 18 doi: 10.1016/j.mrrev.2007.05.001. PMID: 17602853

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