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Abnormal brain glutamine level by MRS

MedGen UID:
1841685
•Concept ID:
C5826436
•
Finding
HPO: HP:0034496

Definition

A deviation from normal in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal brain glutamine level by MRS

Professional guidelines

PubMed

Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications.
Pillinger T, Rogdaki M, McCutcheon RA, Hathway P, Egerton A, Howes OD
Psychopharmacology (Berl) 2019 Jul;236(7):1985-1997. Epub 2019 Feb 28 doi: 10.1007/s00213-019-5188-5. PMID: 30820633Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Horská A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S
Ann Neurol 2009 Jan;65(1):90-7. doi: 10.1002/ana.21562. PMID: 19194883Free PMC Article

Recent clinical studies

Etiology

A comparative study of posterior cingulate metabolism in patients with mild cognitive impairment due to Parkinson's disease or Alzheimer's disease.
Huang M, Yu H, Cai X, Zhang Y, Pu W, Gao B
Sci Rep 2023 Aug 30;13(1):14241. doi: 10.1038/s41598-023-41569-5. PMID: 37648724Free PMC Article
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder.
Biria M, Cantonas LM, Banca P
Curr Top Behav Neurosci 2021;49:231-268. doi: 10.1007/7854_2020_201. PMID: 33751502
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932

Diagnosis

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Hippocampal MRS and subfield volumetry at 7T detects dysfunction not specific to seizure focus.
Voets NL, Hodgetts CJ, Sen A, Adcock JE, Emir U
Sci Rep 2017 Nov 23;7(1):16138. doi: 10.1038/s41598-017-16046-5. PMID: 29170537Free PMC Article
Evaluation of cognitivity, proinflammatory cytokines, and brain magnetic resonance imaging in minimal hepatic encephalopathy induced by cirrhosis and extrahepatic portal vein obstruction.
Yadav SK, Goel A, Saraswat VA, Thomas MA, Wang E, Marincola FM, Haris M, Gupta RK
J Gastroenterol Hepatol 2016 Dec;31(12):1986-1994. doi: 10.1111/jgh.13427. PMID: 27119420
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam.
Pollack MH, Jensen JE, Simon NM, Kaufman RE, Renshaw PF
Prog Neuropsychopharmacol Biol Psychiatry 2008 Apr 1;32(3):739-43. Epub 2007 Nov 28 doi: 10.1016/j.pnpbp.2007.11.023. PMID: 18206286

Therapy

Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Brain and cognition abnormalities in long-term anabolic-androgenic steroid users.
Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG Jr
Drug Alcohol Depend 2015 Jul 1;152:47-56. Epub 2015 May 7 doi: 10.1016/j.drugalcdep.2015.04.023. PMID: 25986964Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam.
Pollack MH, Jensen JE, Simon NM, Kaufman RE, Renshaw PF
Prog Neuropsychopharmacol Biol Psychiatry 2008 Apr 1;32(3):739-43. Epub 2007 Nov 28 doi: 10.1016/j.pnpbp.2007.11.023. PMID: 18206286

Prognosis

Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Global brain atrophy and metabolic dysfunction in LGI1 encephalitis: A prospective multimodal MRI study.
Szots M, Blaabjerg M, Orsi G, Iversen P, Kondziella D, Madsen CG, Garde E, Magnusson PO, Barsi P, Nagy F, Siebner HR, Illes Z
J Neurol Sci 2017 May 15;376:159-165. Epub 2017 Mar 16 doi: 10.1016/j.jns.2017.03.020. PMID: 28431605
3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging.
Nikolova S, Stark SM, Stark CEL
Neurobiol Aging 2017 Jun;54:103-111. Epub 2017 Mar 18 doi: 10.1016/j.neurobiolaging.2017.01.026. PMID: 28363111Free PMC Article
Remote motor system metabolic profile and surgery outcome in cervical spondylotic myelopathy.
Craciunas SC, Gorgan MR, Ianosi B, Lee P, Burris J, Cirstea CM
J Neurosurg Spine 2017 Jun;26(6):668-678. Epub 2017 Mar 17 doi: 10.3171/2016.10.SPINE16479. PMID: 28304238
Evaluation of cognitivity, proinflammatory cytokines, and brain magnetic resonance imaging in minimal hepatic encephalopathy induced by cirrhosis and extrahepatic portal vein obstruction.
Yadav SK, Goel A, Saraswat VA, Thomas MA, Wang E, Marincola FM, Haris M, Gupta RK
J Gastroenterol Hepatol 2016 Dec;31(12):1986-1994. doi: 10.1111/jgh.13427. PMID: 27119420

Clinical prediction guides

J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Decreased Brain GABA Levels in Patients with Migraine Without Aura: An Exploratory Proton Magnetic Resonance Spectroscopy Study.
Wu X, Han S, Yang Y, Dai H, Wu P, Zhao H, Jin X, Li Y
Neuroscience 2022 Apr 15;488:10-19. Epub 2022 Feb 17 doi: 10.1016/j.neuroscience.2022.02.010. PMID: 35182698Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634

Recent systematic reviews

Nature of glutamate alterations in substance dependence: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Chen T, Tan H, Lei H, Li X, Wu Q, Xu X, Ye Y, Zhong N, Du J, Jiang H, Su H, Zhao M
Psychiatry Res Neuroimaging 2021 Sep 30;315:111329. Epub 2021 Jul 7 doi: 10.1016/j.pscychresns.2021.111329. PMID: 34271295
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Moriguchi S, Takamiya A, Noda Y, Horita N, Wada M, Tsugawa S, Plitman E, Sano Y, Tarumi R, ElSalhy M, Katayama N, Ogyu K, Miyazaki T, Kishimoto T, Graff-Guerrero A, Meyer JH, Blumberger DM, Daskalakis ZJ, Mimura M, Nakajima S
Mol Psychiatry 2019 Jul;24(7):952-964. Epub 2018 Oct 12 doi: 10.1038/s41380-018-0252-9. PMID: 30315224Free PMC Article
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.
Yildiz-Yesiloglu A, Ankerst DP
Prog Neuropsychopharmacol Biol Psychiatry 2006 Aug 30;30(6):969-95. Epub 2006 May 4 doi: 10.1016/j.pnpbp.2006.03.012. PMID: 16677749

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