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Increased erythrocyte coproporphyrin concentration

MedGen UID:
1841738
•Concept ID:
C5826759
•
Finding
HPO: HP:0034909

Definition

Concentration of coproporphyrin in erythrocytes above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased erythrocyte coproporphyrin concentration

Recent clinical studies

Etiology

Evaluation of lead exposure in workers at a lead-acid battery factory in Korea: with focus on activity of erythrocyte pyrimidine 5'-nucleotidase (P5N).
Kim Y, Harada K, Ohmori S, Lee BK, Miura H, Ueda A
Occup Environ Med 1995 Jul;52(7):484-8. doi: 10.1136/oem.52.7.484. PMID: 7670624Free PMC Article
Porphyrin metabolism in some malignant diseases.
el-Sharabasy MM, el-Waseef AM, Hafez MM, Salim SA
Br J Cancer 1992 Mar;65(3):409-12. doi: 10.1038/bjc.1992.83. PMID: 1558795Free PMC Article
Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers.
Antonowicz J, Andrzejczak R, Kuliczkowski K, Smolik R
Pol J Occup Med Environ Health 1991;4(4):339-47. PMID: 1817683
Some parameters of haem synthesis in dialysed and non-dialysed uraemic patients.
Yalouris AG, Lyberatos C, Chalevelakis G, Theodosiadou E, Billis A, Raptis S
Scand J Haematol 1986 Nov;37(5):404-10. doi: 10.1111/j.1600-0609.1986.tb02628.x. PMID: 2856853
Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.
Schütz A, Skerfving S
Scand J Work Environ Health 1976 Sep;2(3):176-84. doi: 10.5271/sjweh.2812. PMID: 788149

Diagnosis

Dual porphyria of coexisting variegata and cutanea tarda.
Sieg I, Bhutani LK, Doss MO
Eur J Clin Chem Clin Biochem 1995 Jul;33(7):405-10. doi: 10.1515/cclm.1995.33.7.405. PMID: 7548446
Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers.
Antonowicz J, Andrzejczak R, Kuliczkowski K, Smolik R
Pol J Occup Med Environ Health 1991;4(4):339-47. PMID: 1817683
Effects of lead, zinc and copper absorption on peripheral nerve conduction in metal workers.
Murata K, Araki S, Aono H
Int Arch Occup Environ Health 1987;59(1):11-20. doi: 10.1007/BF00377674. PMID: 3793240
Aminolaevulinate dehydratase porphyria in infancy. A clinical and biochemical study.
Thunell S, Holmberg L, Lundgren J
J Clin Chem Clin Biochem 1987 Jan;25(1):5-14. doi: 10.1515/cclm.1987.25.1.5. PMID: 3559484
History and background of protoporphyrin testing.
Labbé RF
Clin Chem 1977 Feb;23(2 PT. 1):256-9. PMID: 832388

Therapy

Effects of rifampicin on porphyrin metabolism in healthy volunteers.
Tolonen H, Ranta S, Hämäläinen E, Kauppinen R, Hukkanen J
Basic Clin Pharmacol Toxicol 2023 Mar;132(3):281-291. Epub 2022 Dec 26 doi: 10.1111/bcpt.13826. PMID: 36535687
Altered activity of heme biosynthesis pathway enzymes in individuals chronically exposed to arsenic in Mexico.
Hernández-Zavala A, Del Razo LM, García-Vargas GG, Aguilar C, Borja VH, Albores A, Cebrián ME
Arch Toxicol 1999 Mar;73(2):90-5. doi: 10.1007/s002040050592. PMID: 10350189
Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers.
Antonowicz J, Andrzejczak R, Kuliczkowski K, Smolik R
Pol J Occup Med Environ Health 1991;4(4):339-47. PMID: 1817683
Effects of haem arginate on variegate porphyria.
Timonen K, Mustajoki P, Tenhunen R, Lauharanta J
Br J Dermatol 1990 Sep;123(3):381-7. doi: 10.1111/j.1365-2133.1990.tb06299.x. PMID: 2206975
Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.
Schütz A, Skerfving S
Scand J Work Environ Health 1976 Sep;2(3):176-84. doi: 10.5271/sjweh.2812. PMID: 788149

Prognosis

Aminolaevulinate dehydratase porphyria in infancy. A clinical and biochemical study.
Thunell S, Holmberg L, Lundgren J
J Clin Chem Clin Biochem 1987 Jan;25(1):5-14. doi: 10.1515/cclm.1987.25.1.5. PMID: 3559484
Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.
Schütz A, Skerfving S
Scand J Work Environ Health 1976 Sep;2(3):176-84. doi: 10.5271/sjweh.2812. PMID: 788149

Clinical prediction guides

The third case of Doss porphyria (delta-amino-levulinic acid dehydratase deficiency) in Germany.
Doss MO, Stauch T, Gross U, Renz M, Akagi R, Doss-Frank M, Seelig HP, Sassa S
J Inherit Metab Dis 2004;27(4):529-36. doi: 10.1023/B:BOLI.0000037341.21975.9d. PMID: 15303011
Immunological, enzymatic and biochemical studies of uroporphyrinogen III-synthase deficiency in 20 patients with congenital erythropoietic porphyria.
Freesemann AG, Gross U, Bensidhoum M, de Verneuil H, Doss MO
Eur J Biochem 1998 Oct 1;257(1):149-53. doi: 10.1046/j.1432-1327.1998.2570149.x. PMID: 9799113
Coproporphyrinogen oxidase activity and porphyrin concentrations in peripheral red blood cells in hereditary sideroblastic anaemia.
Pasanen AV, Eklöf M, Tenhunen R
Scand J Haematol 1985 Mar;34(3):235-7. doi: 10.1111/j.1600-0609.1985.tb02784.x. PMID: 3992190
Mechanism of increased osmotic resistance of red cells in workers exposed to lead.
Karai I, Fukumoto K, Horiguchi S
Br J Ind Med 1982 May;39(2):153-6. doi: 10.1136/oem.39.2.153. PMID: 7066232Free PMC Article
Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.
Schütz A, Skerfving S
Scand J Work Environ Health 1976 Sep;2(3):176-84. doi: 10.5271/sjweh.2812. PMID: 788149

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